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VARIABLE P-GLYCOPROTEIN IMMUNOREACTIVITY UNRELATED TO CYTOTOXIC DRUG-RESISTANCE IN-VITRO OF HUMAN ADRENOCORTICAL CARCINOMA

  • Authors:
    • C BACKLIN
    • H FRIDBORG
    • C JUHLIN
    • P NYGREN
    • G AKERSTROM
    • J RASTAD
    • R LARSSON

  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.565
  • Pages: 565-571
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Abstract

Human adrenocortical tissue was immunohistochemically investigated with monoclonal antibodies C219 and JSB-1 for expression of P-glycoprotein (Pgp) associated with resistance to multiple cytotoxic drugs. All normal (n=7) and adenomatous (n=3) glands strongly expressed the protein, while the cancers (n=15) demonstrated variable Pgp reactivity. Cytotoxic drug sensitivity testing in vitro on freshly dispersed cells from one normal adrenal gland and from 6 carcinomas with no to extensive Pgp reactivity demonstrated universally poor sensitivity to 9 standard drugs including those with Pgp mediated resistance. The findings indicate that immunohistochemical staining for Pgp cannot be used to predict cytotoxic drug resistance and that other mechanisms mediate cytotoxic drug resistance in adrenocortical carcinoma.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
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Spandidos Publications style
BACKLIN C, FRIDBORG H, JUHLIN C, NYGREN P, AKERSTROM G, RASTAD J and LARSSON R: VARIABLE P-GLYCOPROTEIN IMMUNOREACTIVITY UNRELATED TO CYTOTOXIC DRUG-RESISTANCE IN-VITRO OF HUMAN ADRENOCORTICAL CARCINOMA. Int J Oncol 5: 565-571, 1994
APA
BACKLIN, C., FRIDBORG, H., JUHLIN, C., NYGREN, P., AKERSTROM, G., RASTAD, J., & LARSSON, R. (1994). VARIABLE P-GLYCOPROTEIN IMMUNOREACTIVITY UNRELATED TO CYTOTOXIC DRUG-RESISTANCE IN-VITRO OF HUMAN ADRENOCORTICAL CARCINOMA. International Journal of Oncology, 5, 565-571. https://doi.org/10.3892/ijo.5.3.565
MLA
BACKLIN, C., FRIDBORG, H., JUHLIN, C., NYGREN, P., AKERSTROM, G., RASTAD, J., LARSSON, R."VARIABLE P-GLYCOPROTEIN IMMUNOREACTIVITY UNRELATED TO CYTOTOXIC DRUG-RESISTANCE IN-VITRO OF HUMAN ADRENOCORTICAL CARCINOMA". International Journal of Oncology 5.3 (1994): 565-571.
Chicago
BACKLIN, C., FRIDBORG, H., JUHLIN, C., NYGREN, P., AKERSTROM, G., RASTAD, J., LARSSON, R."VARIABLE P-GLYCOPROTEIN IMMUNOREACTIVITY UNRELATED TO CYTOTOXIC DRUG-RESISTANCE IN-VITRO OF HUMAN ADRENOCORTICAL CARCINOMA". International Journal of Oncology 5, no. 3 (1994): 565-571. https://doi.org/10.3892/ijo.5.3.565