RECOMBINANT RET ONCOGENE PRODUCTS INDUCE T-LYMPHOCYTE PROLIFERATION, AND SUPPRESS LYMPHOMA DERIVED FROM RET TRANSGENIC MICE

  • Authors:
    • D YAN
    • K ISOBE
    • M TAKAHASHI
    • I NAKASHIMA
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.661
  • Pages: 661-665
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Abstract

3Recombinant ret oncogene products in complete Freund's adjuvant were injected into normal mice and ret oncogene transgenic mice. Spleen cells from the mice immunized with ret proteins were highly proliferated in vitro by the stimulation of ret proteins. The proliferating T cells have CD4(+) phenotype and secreated CTLL-2 reactive interleukins. The peritoneal exudate cells from ret protein-immunized mice suppressed ret-2 lymphoma, which was derived from ret lymphoma transgenic mice. The peritoneal exudate cells from ret melanoma transgenic mice did not suppress ret-2 lymphoma, when they were immunized with ret proteins.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
YAN D, ISOBE K, TAKAHASHI M and NAKASHIMA I: RECOMBINANT RET ONCOGENE PRODUCTS INDUCE T-LYMPHOCYTE PROLIFERATION, AND SUPPRESS LYMPHOMA DERIVED FROM RET TRANSGENIC MICE. Int J Oncol 5: 661-665, 1994.
APA
YAN, D., ISOBE, K., TAKAHASHI, M., & NAKASHIMA, I. (1994). RECOMBINANT RET ONCOGENE PRODUCTS INDUCE T-LYMPHOCYTE PROLIFERATION, AND SUPPRESS LYMPHOMA DERIVED FROM RET TRANSGENIC MICE. International Journal of Oncology, 5, 661-665. https://doi.org/10.3892/ijo.5.3.661
MLA
YAN, D., ISOBE, K., TAKAHASHI, M., NAKASHIMA, I."RECOMBINANT RET ONCOGENE PRODUCTS INDUCE T-LYMPHOCYTE PROLIFERATION, AND SUPPRESS LYMPHOMA DERIVED FROM RET TRANSGENIC MICE". International Journal of Oncology 5.3 (1994): 661-665.
Chicago
YAN, D., ISOBE, K., TAKAHASHI, M., NAKASHIMA, I."RECOMBINANT RET ONCOGENE PRODUCTS INDUCE T-LYMPHOCYTE PROLIFERATION, AND SUPPRESS LYMPHOMA DERIVED FROM RET TRANSGENIC MICE". International Journal of Oncology 5, no. 3 (1994): 661-665. https://doi.org/10.3892/ijo.5.3.661