INTEGRINS AND THEIR EXTRACELLULAR-MATRIX LIGANDS IN GASTRIC-CANCER

  • Authors:
    • YD RAMKISSOON
    • R DEL BUONO
    • IM FILIPE
    • S BUK
    • PA HALL
    • M PIGNATELLI
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.689
  • Pages: 689-695
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Abstract

Extracellular matrix (ECM) proteins and their specific cellular receptors, play an important role in the regulation of epithelial morphogenesis and differentiation. Alterations in their expression and function have been found in a number of malignant tumours and these changes may help to explain their dedifferentiation and altered behaviour. In this study we have investigated expression and distribution of the epithelial beta 1 integrins (alpha 2 beta 1, alpha 3 beta 1 and alpha 6 beta 1) and their ECM ligands (fibronectin, tenascin and laminin) in normal and neoplastic tissue. An up-regulation of two isoforms of fibronectin, and tenascin was seen in tumour associated matrix compared to normal stroma. Loss or down regulation of alpha integrin chains was seen more frequently in poorly differentiated carcinomas (alpha 2 p=0.002; alpha 3 p=0.013; alpha 6 p=0.0012) irrespective of tumour type (diffuse or intestinal) than in well/moderately differentiated tumours. Cell adhesion assays revealed that the ability of gastric carcinoma cell lines to bind matrix glycoproteins correlated to their degree of differentiation. Furthermore, poorly differentiated cell lines showed a down-regulation of alpha 2 and alpha 6 integrin expression. These data indicate that architectural and cytological differentiation in gastric carcinoma relates to altered patterns of expression of matrix glycoproteins and their receptors. The traditional Lauren classification seems to reflect these differences in cell-matrix interactions. Differing patterns of expression of those molecules involved in cell-matrix interactions may prove to be a more objective and biologically more relevant means of classifying gastric cancer.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RAMKISSOON Y, DEL BUONO R, FILIPE I, BUK S, HALL P and PIGNATELLI M: INTEGRINS AND THEIR EXTRACELLULAR-MATRIX LIGANDS IN GASTRIC-CANCER. Int J Oncol 5: 689-695, 1994
APA
RAMKISSOON, Y., DEL BUONO, R., FILIPE, I., BUK, S., HALL, P., & PIGNATELLI, M. (1994). INTEGRINS AND THEIR EXTRACELLULAR-MATRIX LIGANDS IN GASTRIC-CANCER. International Journal of Oncology, 5, 689-695. https://doi.org/10.3892/ijo.5.3.689
MLA
RAMKISSOON, Y., DEL BUONO, R., FILIPE, I., BUK, S., HALL, P., PIGNATELLI, M."INTEGRINS AND THEIR EXTRACELLULAR-MATRIX LIGANDS IN GASTRIC-CANCER". International Journal of Oncology 5.3 (1994): 689-695.
Chicago
RAMKISSOON, Y., DEL BUONO, R., FILIPE, I., BUK, S., HALL, P., PIGNATELLI, M."INTEGRINS AND THEIR EXTRACELLULAR-MATRIX LIGANDS IN GASTRIC-CANCER". International Journal of Oncology 5, no. 3 (1994): 689-695. https://doi.org/10.3892/ijo.5.3.689