All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway

Corrigendum in: /10.3892/ijo.2019.4817

  • Authors:
    • Nian Wu
    • Ruidong Li
    • Zijun Meng
    • Mao Nie
    • Qianzhao Chen
    • Baicheng He
    • Zhongliang Deng
    • Liangjun Yin
  • View Affiliations

  • Published online on: March 13, 2017     https://doi.org/10.3892/ijo.2017.3910
  • Pages: 1363-1371
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Abstract

Osteosarcoma (OS) is the most common malignant bone tumour and is considered to be a disease caused by a dysfunction in differentiation. Bone morphogenetic protein 9 (BMP9) is the most potent osteogenic factor in mesenchymal stem cells, but it cannot induce osteogenic differentiation in OS cells; this might be one of the determinants in the pathogenesis of OS. All-trans retinoic acid (ATRA) can induce osteogenic differentiation of OS cells and potentiate BMP9-induced osteogenesis in preadipocytes. However, the concomitant effect of ATRA and BMP9 in OS cells is unclear; therefore, in the present study, we focused on this topic. The results showed that BMP9 significantly promoted the proliferation of human OS 143B cells and did not induce osteogenic differentiation of cells in vitro (p<0.01). ATRA inhibited proliferation and induced osteogenesis in 143B cells; these effects could be enhanced by BMP9 overexpression (p<0.05). ATRA could significantly increase the level of phosphorylated p38 MAPK (p-p38) in 143B cells, while BMP9 did not have any significant effect. Notably, BMP9 overexpression enhanced the ability of ATRA to increase the levels of p-p38. Both the osteogenic differentiation and the anti-proliferative activity of BMP9 in the presence of ATRA decreased upon treatment with a specific inhibitor of p38 MAPK (SB203580) (p<0.01). This study indicates that the osteogenic differentiation ability of BMP9 in 143B cells can be restored by ATRA, and the combination of BMP9 and ATRA generated a stronger anti-proliferative effect on 143B cells than ATRA alone. This result may be due to the activation of the p38 MAPK pathway.
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April-2017
Volume 50 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wu N, Li R, Meng Z, Nie M, Chen Q, He B, Deng Z and Yin L: All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway Corrigendum in /10.3892/ijo.2019.4817. Int J Oncol 50: 1363-1371, 2017
APA
Wu, N., Li, R., Meng, Z., Nie, M., Chen, Q., He, B. ... Yin, L. (2017). All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway Corrigendum in /10.3892/ijo.2019.4817. International Journal of Oncology, 50, 1363-1371. https://doi.org/10.3892/ijo.2017.3910
MLA
Wu, N., Li, R., Meng, Z., Nie, M., Chen, Q., He, B., Deng, Z., Yin, L."All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway Corrigendum in /10.3892/ijo.2019.4817". International Journal of Oncology 50.4 (2017): 1363-1371.
Chicago
Wu, N., Li, R., Meng, Z., Nie, M., Chen, Q., He, B., Deng, Z., Yin, L."All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway Corrigendum in /10.3892/ijo.2019.4817". International Journal of Oncology 50, no. 4 (2017): 1363-1371. https://doi.org/10.3892/ijo.2017.3910