Open Access

Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer

  • Authors:
    • Yang Liu
    • Shuanshuan Xie
    • Jie Zeng
    • Xiaolian Song
    • Min Tan
    • Dannong He
    • Jie Wang
    • Ping Wang
    • Jun Zhu
    • Changhui Wang
  • View Affiliations

  • Published online on: June 6, 2019     https://doi.org/10.3892/ijo.2019.4822
  • Pages: 462-472
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Adenylyl cyclase‑associated protein 1 (CAP1) belongs to a family of cyclase‑associated proteins that are involved in the development of cancerous tumors. A previous study by our group confirmed the association between CAP1, lung cancer and the metastasis of cancer cells. In the present study, poly(lactic‑polyglycolic acid; PLGA)/CAP1‑small interfering (si)RNA nanoparticles were prepared and delivered into A549 cells. The performance of PLGA/siCAP1‑siRNA nanoparticles for siRNA delivery was measured based on the results of migration assay and animal experiments. The multifunctional nanoparticles were determined to be capable of inhibiting CAP1 expression, which reduced NSCLC metastasis in vitro and in vivo. Therefore, the findings of the current study highlighted the potential use of PLGA/siCAP1‑siRNA nanoparticles for the treatment of NSCLC metastasis.
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August-2019
Volume 55 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Y, Xie S, Zeng J, Song X, Tan M, He D, Wang J, Wang P, Zhu J, Wang C, Wang C, et al: Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer. Int J Oncol 55: 462-472, 2019
APA
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D. ... Wang, C. (2019). Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer. International Journal of Oncology, 55, 462-472. https://doi.org/10.3892/ijo.2019.4822
MLA
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D., Wang, J., Wang, P., Zhu, J., Wang, C."Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer". International Journal of Oncology 55.2 (2019): 462-472.
Chicago
Liu, Y., Xie, S., Zeng, J., Song, X., Tan, M., He, D., Wang, J., Wang, P., Zhu, J., Wang, C."Adenylyl cyclase‑associated protein 1‑targeted nanoparticles as a novel strategy for the treatment of metastatic non‑small cell lung cancer". International Journal of Oncology 55, no. 2 (2019): 462-472. https://doi.org/10.3892/ijo.2019.4822