Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease

  • Authors:
    • V Lorusso
    • A Timurian
    • M Brandi
    • A Pellecchia
    • A Cramarossa
    • F Marzullo
    • M deLena
  • View Affiliations

  • Published online on: April 1, 1996     https://doi.org/10.3892/ijo.8.4.669
  • Pages: 669-674
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Abstract

The aim of the study was to verify the possibility of treating patients with poor prognosis early-intermediate Hodgkin's disease with a combined modality therapy consisting of three cycles of ABVD followed by extended field irradiation (EFRT). No patient had bulky mediastinum or had previously been administered chemo- or radiotherapy. At pathological restaging, 40/44 (91%) evaluable patients achieved complete responses (CR). After a ten-year followup, freedom from progression (FFP), relapse-free survival (RFS) and overall survival (OS) were 80%, 83% and 81%, respectively. Of the prognostic factors, univariate analysis showed that only stage III negatively influenced RFS, but not OS. Toxicity was mild except for subclinical mediastinal fibrosis in 32.5% of CR patients. No patient reported reduced fertility. Two cases of second neoplasms were recorded: one ameboid glioma and one thymoma, both occurring within five years after discontinuing chemo-radiotherapy. Our data suggest that three cycles of ABVD preceeding EFRT is an effective treatment for poor prognosis early-intermediate stage Hodgkin's disease; nevertheless, stage III patients and some stage II patients with unfavorable prognostic factors should be treated with a more aggressive approach.

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April 1996
Volume 8 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Lorusso, V., Timurian, A., Brandi, M., Pellecchia, A., Cramarossa, A., Marzullo, F., & deLena, M. (1996). Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease. International Journal of Oncology, 8, 669-674. https://doi.org/10.3892/ijo.8.4.669
MLA
Lorusso, V., Timurian, A., Brandi, M., Pellecchia, A., Cramarossa, A., Marzullo, F., deLena, M."Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease". International Journal of Oncology 8.4 (1996): 669-674.
Chicago
Lorusso, V., Timurian, A., Brandi, M., Pellecchia, A., Cramarossa, A., Marzullo, F., deLena, M."Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease". International Journal of Oncology 8, no. 4 (1996): 669-674. https://doi.org/10.3892/ijo.8.4.669