Open Access

Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience

  • Authors:
    • Fang Xiao
    • Jia‑Zi Shi
    • Yang Liu
    • Tao Liu
    • Jie Wang
    • Yu‑Shan Liu
    • Jun‑Kai Wang
    • Lin‑Hui Wang
  • View Affiliations

  • Published online on: December 18, 2018     https://doi.org/10.3892/mco.2018.1794
  • Pages: 343-351
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to assess the oncological and functional outcomes of testis‑sparing surgery (TSS) for testicular tumors compared with radical orchiectomy (RO) in a single center. A retrospective comparative cohort study was conducted in Changzheng Hospital. Patients were identified using the hospital information system from January 1999 to December 2016, collecting all of the data regarding clinical, treatment and prognostic profiles. Patient follow‑up was also executed to obtain information on patients' survival status, serum markers profiles, disease progression, androgen substitution requirement and paternity status. In total 158 patients were enrolled into the cohort study, including 23 TSS cases. The TSS procedure was primarily conducted in younger patients (average age, 31.9 vs. 47.7 years) or those with smaller tumors (average tumor diameter, 26.0 vs. 51.5 mm). The overall survival and recurrence free survival revealed no differences in the two groups, suggesting similar oncological outcomes. Kaplan‑Maier analysis demonstrated a higher cumulative paternity rate in the TSS group than in RO group, indicating a possible advantage of preserving patients' fertility in TSS over RO. TSS with proper adjuvant therapies proved to be a promising alternative in the avoidance of emasculation, infertility, life‑long androgen substitution and other psychosexual difficulties, as the oncological outcomes were not inferior to RO in the selected cases. However, further investigation is required in order to assess its oncological and functional values.
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March-2019
Volume 10 Issue 3

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Spandidos Publications style
Xiao F, Shi JZ, Liu Y, Liu T, Wang J, Liu YS, Wang JK and Wang LH: Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience. Mol Clin Oncol 10: 343-351, 2019
APA
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y. ... Wang, L. (2019). Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience. Molecular and Clinical Oncology, 10, 343-351. https://doi.org/10.3892/mco.2018.1794
MLA
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y., Wang, J., Wang, L."Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience". Molecular and Clinical Oncology 10.3 (2019): 343-351.
Chicago
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y., Wang, J., Wang, L."Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience". Molecular and Clinical Oncology 10, no. 3 (2019): 343-351. https://doi.org/10.3892/mco.2018.1794