Assessment of acute obstructive pancreatitis by magnetic resonance imaging: Predicting the occurrence of pancreatic
fistula following pancreatoduodenectomy

Shi,Zhenshan; Li,Xiumei; Li,Yueming; You,Ruixiong; Cao,Dairong; Chen,Qunlin; Ramen,Kamisha; Loosa,Vikash Sahadeo

doi:10.3892/mco.2019.1799

Assessment of acute obstructive pancreatitis by magnetic resonance imaging: Predicting the occurrence of pancreatic fistula following pancreatoduodenectomy

Authors:
- Zhenshan Shi
- Xiumei Li
- Yueming Li
- Ruixiong You
- Dairong Cao
- Qunlin Chen
- Kamisha Ramen
- Vikash Sahadeo Loosa
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Affiliations: Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Radiology, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
Published online on: January 9, 2019 https://doi.org/10.3892/mco.2019.1799
Pages: 371-376

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Abstract

The aim of the present study was to assess the effect of preoperative acute obstructive pancreatitis on the risk of the occurrence of pancreatic fistula (PF) following pancreaticoduodenectomy. A total of 22 patients who developed postoperative PF were carefully matched with 22 control patients without PF according to demographic data, pancreatic pathology, presenting symptoms and other surgery‑associated parameters. These parameters were compared between these two groups. The mean pancreatic apparent diffusion coefficient (ADC) values in the fistula group were 1.14±0.31x10‑3 mm2/s, which was significantly decreased compared with the non‑fistula group (1.48±0.44x10‑3 mm2/s) (P=0.005). The pancreas‑muscle signal intensity (SI) ratio on fat‑suppressed T1 weighted image (rT1) in the fistula group was 1.71±0.25, which was significantly increased compared with the non‑fistula group (1.25±0.29) (P<0.001). The pancreas‑muscle SI ratios on fat‑suppressed T2 weighted image (T2WI) in the fistula group and the non‑fistula group were 0.72±0.08 and 0.62±0.07, respectively (P=0.79). There was no significant difference in pancreas‑muscle SI ratio on fat‑suppressed T2‑weighted image (rT2) value between these two groups. Based on the receiver operating characteristic curve, the optimal cut‑off value of ADC as a criterion for prediction of pancreatic fistula was 1.29x10‑3 mm2/s, which yielded a sensitivity of 77.3% and a specificity of 63.6%. In conclusion, the severity of acute obstructive pancreatitis was negatively associated with ADC values and pancreas‑muscle SI ratio on rT1 images, which may be useful for predicting the occurrence of PF preoperatively.

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