Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review

  • Authors:
    • Halima Siddiqui
    • Ayat Al-Ghafari
    • Hani Choudhry
    • Huda Al Doghaither
  • View Affiliations

  • Published online on: May 31, 2019     https://doi.org/10.3892/mco.2019.1872
  • Pages: 167-172
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Abstract

Long non‑coding RNAs (lncRNAs) are newly identified potential biological and gene regulators. Similar to other cell‑free circulating cancer‑related nucleic acids, lncRNAs are released in the peripheral circulation of cancer patients and allow for non‑invasive gene expression assessment. lncRNAs are considered to be promising biomarkers for cancer prognosis and diagnosis. Several lncRNAs have been found to regulate developmental processes in a number of biological disorders. Recent studies indicated that lncRNAs are associated with numerous diseases, most notably cancer, as they were found to be highly expressed or silenced in a number of human cancers, including colorectal cancer (CRC). Despite advances in the current detection methods, over half of cancer patients succumb to the disease, as several CRC cases are diagnosed at an advanced stage. Due to the lack of non‑invasive and low‑cost prognostic and diagnostic tests for CRC, the identification of novel, potentially effective biomarkers has been attracting increasing attention in recent cancer research. The present review focused on the most widely applied lncRNAs in cancer detection, including CRC, in vitro.
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August-2019
Volume 11 Issue 2

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Spandidos Publications style
Siddiqui H, Al-Ghafari A, Choudhry H and Al Doghaither H: Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review. Mol Clin Oncol 11: 167-172, 2019.
APA
Siddiqui, H., Al-Ghafari, A., Choudhry, H., & Al Doghaither, H. (2019). Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review. Molecular and Clinical Oncology, 11, 167-172. https://doi.org/10.3892/mco.2019.1872
MLA
Siddiqui, H., Al-Ghafari, A., Choudhry, H., Al Doghaither, H."Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review". Molecular and Clinical Oncology 11.2 (2019): 167-172.
Chicago
Siddiqui, H., Al-Ghafari, A., Choudhry, H., Al Doghaither, H."Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review". Molecular and Clinical Oncology 11, no. 2 (2019): 167-172. https://doi.org/10.3892/mco.2019.1872