Molecular characteristics of breast cancer according to clinicopathological factors

  • Authors:
    • Joanna Huszno
    • Zofia Kolosza
  • View Affiliations

  • Published online on: May 28, 2019     https://doi.org/10.3892/mco.2019.1869
  • Pages: 192-200
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Abstract

The purpose of the present study was to evaluate the correlation between molecular factors such as BRCA1 DNA repair associated (BRCA1), checkpoint kinase 2 (CHEK2) and nucleotide binding oligomerization domain containing 2 (NOD2) gene mutations and clinicopathological factors in patients with breast cancer (BC). Prognostic factors were analyzed in BC patients with confirmed BRCA1 (n=73), CHEK2 (n=51) and NOD2 (n=31) mutations. The control group was selected from BC patients without mutations (n=392). The BRCA‑associated cancer cases were significantly more often triple negative compared with sporadic cancer (62% vs. 14%; P=0.0001). Luminal B HER2‑positive and HER2‑positive non‑luminal subtypes were observed more often in the control group (33 and 17%). The luminal A subtype was detected in 53% of CHEK2 mutation carriers and 45% of NOD2 mutation carriers. A lower histological grade was observed significantly more often in patients with CHEK2 mutations in comparison with the control group (88 vs. 69%; P=0.003). Lymph nodes without metastases were reported more frequently in NOD2 mutation carriers (74 vs. 54%; P=0.038), in BRCA1 mutations (73 vs. 54%; P=0.004) and, although not significantly, in CHEK2 mutation carriers (69 vs. 54%; P=0.071) compared with the control group. In conclusion, BRCA1 mutation was associated with TNBC and the luminal B HER2 (‑) subtype. HER2‑positive subtypes were characteristic of the control group. CHEK2 and NOD2 mutation carriers had a more favorable profile of prognostic factors.
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August 2019
Volume 11 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Huszno, J., & Huszno, J. (2019). Molecular characteristics of breast cancer according to clinicopathological factors. Molecular and Clinical Oncology, 11, 192-200. https://doi.org/10.3892/mco.2019.1869
MLA
Huszno, J., Kolosza, Z."Molecular characteristics of breast cancer according to clinicopathological factors". Molecular and Clinical Oncology 11.2 (2019): 192-200.
Chicago
Huszno, J., Kolosza, Z."Molecular characteristics of breast cancer according to clinicopathological factors". Molecular and Clinical Oncology 11, no. 2 (2019): 192-200. https://doi.org/10.3892/mco.2019.1869