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Article

Molecular characteristics of breast cancer according to clinicopathological factors

  • Authors:
    • Joanna Huszno
    • Zofia Kolosza
  • View Affiliations / Copyright

    Affiliations: I Radiation and Clinical Oncology Department, Maria Skłodowska‑Curie Memorial Cancer Center and Institute of Oncology, 44‑101 Gliwice, Poland, Biostatistic Unit, Maria Skłodowska‑Curie Memorial Cancer Center and Institute of Oncology, 44‑101 Gliwice, Poland
  • Pages: 192-200
    |
    Published online on: May 28, 2019
       https://doi.org/10.3892/mco.2019.1869
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Abstract

The purpose of the present study was to evaluate the correlation between molecular factors such as BRCA1 DNA repair associated (BRCA1), checkpoint kinase 2 (CHEK2) and nucleotide binding oligomerization domain containing 2 (NOD2) gene mutations and clinicopathological factors in patients with breast cancer (BC). Prognostic factors were analyzed in BC patients with confirmed BRCA1 (n=73), CHEK2 (n=51) and NOD2 (n=31) mutations. The control group was selected from BC patients without mutations (n=392). The BRCA‑associated cancer cases were significantly more often triple negative compared with sporadic cancer (62% vs. 14%; P=0.0001). Luminal B HER2‑positive and HER2‑positive non‑luminal subtypes were observed more often in the control group (33 and 17%). The luminal A subtype was detected in 53% of CHEK2 mutation carriers and 45% of NOD2 mutation carriers. A lower histological grade was observed significantly more often in patients with CHEK2 mutations in comparison with the control group (88 vs. 69%; P=0.003). Lymph nodes without metastases were reported more frequently in NOD2 mutation carriers (74 vs. 54%; P=0.038), in BRCA1 mutations (73 vs. 54%; P=0.004) and, although not significantly, in CHEK2 mutation carriers (69 vs. 54%; P=0.071) compared with the control group. In conclusion, BRCA1 mutation was associated with TNBC and the luminal B HER2 (‑) subtype. HER2‑positive subtypes were characteristic of the control group. CHEK2 and NOD2 mutation carriers had a more favorable profile of prognostic factors.
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Copy and paste a formatted citation
Spandidos Publications style
Huszno J and Kolosza Z: Molecular characteristics of breast cancer according to clinicopathological factors. Mol Clin Oncol 11: 192-200, 2019.
APA
Huszno, J., & Kolosza, Z. (2019). Molecular characteristics of breast cancer according to clinicopathological factors. Molecular and Clinical Oncology, 11, 192-200. https://doi.org/10.3892/mco.2019.1869
MLA
Huszno, J., Kolosza, Z."Molecular characteristics of breast cancer according to clinicopathological factors". Molecular and Clinical Oncology 11.2 (2019): 192-200.
Chicago
Huszno, J., Kolosza, Z."Molecular characteristics of breast cancer according to clinicopathological factors". Molecular and Clinical Oncology 11, no. 2 (2019): 192-200. https://doi.org/10.3892/mco.2019.1869
Copy and paste a formatted citation
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Spandidos Publications style
Huszno J and Kolosza Z: Molecular characteristics of breast cancer according to clinicopathological factors. Mol Clin Oncol 11: 192-200, 2019.
APA
Huszno, J., & Kolosza, Z. (2019). Molecular characteristics of breast cancer according to clinicopathological factors. Molecular and Clinical Oncology, 11, 192-200. https://doi.org/10.3892/mco.2019.1869
MLA
Huszno, J., Kolosza, Z."Molecular characteristics of breast cancer according to clinicopathological factors". Molecular and Clinical Oncology 11.2 (2019): 192-200.
Chicago
Huszno, J., Kolosza, Z."Molecular characteristics of breast cancer according to clinicopathological factors". Molecular and Clinical Oncology 11, no. 2 (2019): 192-200. https://doi.org/10.3892/mco.2019.1869
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