Dedifferentiated liposarcoma of the thyroid gland: A case report

Kishimoto,Yo; Ohno Kishimoto,Ayami; Yamada,Yosuke; Kitano,Masayuki; Kitada,Yuji; Kitamura,Morimasa; Tateya,Ichiro; Sonobe,Makoto; Omori,Koichi

doi:10.3892/mco.2019.1882

Dedifferentiated liposarcoma of the thyroid gland: A case report

Authors:
- Yo Kishimoto
- Ayami Ohno Kishimoto
- Yosuke Yamada
- Masayuki Kitano
- Yuji Kitada
- Morimasa Kitamura
- Ichiro Tateya
- Makoto Sonobe
- Koichi Omori
View Affiliations

Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Diagnosic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Otolaryngology‑Head and Neck Surgery, Japanese Red Cross Osaka Hospital, Osaka 543‑8555, Japan, Department of Otolaryngology‑Head and Neck Surgery, Kitano Hospital Tazuke Medical Research Institute, Osaka 530‑8480, Japan, Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan
Published online on: June 18, 2019 https://doi.org/10.3892/mco.2019.1882
Pages: 219-224
Copyright: © Kishimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Liposarcoma is one of the most common soft tissue tumors that affect adults. Liposarcoma is typically identified in the retroperitoneum, trunk and extremities as a slow‑growing mass, yet is rare in the thyroid gland. Herein, we report a case of dedifferentiated liposarcoma that developed in the thyroid gland, and performed a literature review. A 66‑year‑old male with a history of well‑differentiated liposarcoma in the thymus presented with a rapidly enlarging mass in the thyroid gland. Malignancy was suspected due to the local extension of the tumor, and complete resection of the tumor was achieved. Tissue diagnosis from the tumor following surgery revealed that dedifferentiated liposarcoma, and tumor progression was difficult to control with adjuvant radiation and chemotherapy. This is, to the best of our knowledge, the first case to report dedifferentiated liposarcoma in the thyroid gland, and the difficulty in initial diagnosis as well as the aggressive features of dedifferentiated liposarcoma are highlighted.

View Figures

View References

1	Blumberg JM, Jedrych J, Costa J and Judson B: Cervical dedifferentiated liposarcoma with meningothelial-like whorling. Head Neck Pathol. 6:476–480. 2012. View Article : Google Scholar : PubMed/NCBI
2	Huang GW, Li YX and Hu ZL: Primary myxoid liposarcoma of the thyroid gland. J Clin Pathol. 62:1037–1038. 2009. View Article : Google Scholar : PubMed/NCBI
3	Azar AR, Weynand B, Daumerie C and Coche E: Metastatic liposarcoma of the thyroid gland. Br J Radiol. 76:750–752. 2003. View Article : Google Scholar : PubMed/NCBI
4	Davis EC, Ballo MT, Luna MA, Patel SR, Roberts DB, Nong X and Sturgis EM: Liposarcoma of the head and neck: The University of Texas M. D. Anderson Cancer Center experience. Head Neck. 31:28–36. 2009. View Article : Google Scholar : PubMed/NCBI
5	Nielsen VT, Knudsen N and Holm IE: Liposarcoma of the thyroid gland. Tumori. 72:499–502. 1986. View Article : Google Scholar : PubMed/NCBI
6	Griem KL, Robb PK, Caldarelli DD and Templeton AC: Radiation-induced sarcoma of the thyroid. Arch Otolaryngol Head Neck Surg. 115:991–993. 1989. View Article : Google Scholar : PubMed/NCBI
7	Andrion A, Gaglio A, Dogliani N, Bosco E and Mazzucco G: Liposarcoma of the thyroid gland. Fine-needle aspiration cytology, immunohistology, and ultrastructure. Am J Clin Pathol. 95:675–679. 1991. View Article : Google Scholar : PubMed/NCBI
8	Mitra A, Fisher C, Rhys-Evans P and Harmer C: Liposarcoma of the thyroid. Sarcoma. 8:91–96. 2004. View Article : Google Scholar : PubMed/NCBI
9	Kilic M, Keskek M, Albayrak L, Ertan T, Gocmen E and Koc M: Liposarcoma of the thyroid gland: A case report. Acta Chir Belg. 107:73–74. 2007. View Article : Google Scholar : PubMed/NCBI
10	Awad WI, Evans PHR, Nicholson AG and Goldstraw P: Liposarcoma of the thyroid gland mimicking retrosternal goiter. Ann Thorac Surg. 75:566–568. 2003. View Article : Google Scholar : PubMed/NCBI
11	Kumar V, Raj A and Rathore PK: Liposarcoma of thyroid gland: A review of the gained experience. Indian J Cancer. 51:548–549. 2014. View Article : Google Scholar : PubMed/NCBI
12	Bashir H, Nawaz MK, Shah MA and Ahmad E: Pleomorphic liposarcoma metastatic to the thyroid gland. Clin Nucl Med. 27:9–10. 2002. View Article : Google Scholar : PubMed/NCBI
13	Brandwein-Gensler M, Urken M and Wang B: Collision tumor of the thyroid: A case report of metastatic liposarcoma plus papillary thyroid carcinoma. Head Neck. 26:637–641. 2004. View Article : Google Scholar : PubMed/NCBI
14	Tysome JR, Sandison A and Clarke PM: Myxoid liposarcoma metastatic to the thyroid gland: A case report and literature review. J Laryngol Otol. 120:511–513. 2006. View Article : Google Scholar : PubMed/NCBI
15	Golledge J, Fisher C and Rhys-Evans PH: Head and neck liposarcoma. Cancer. 76:1051–1058. 1995. View Article : Google Scholar : PubMed/NCBI
16	Hui JY: Epidemiology and etiology of sarcomas. Surg Clin North Am. 96:901–914. 2016. View Article : Google Scholar : PubMed/NCBI
17	Penel N, Grosjean J, Robin YM, Vanseymortier L, Clisant S and Adenis A: Frequency of certain established risk factors in soft tissue sarcomas in adults: A prospective descriptive study of 658 cases. Sarcoma. 2008:4593862008. View Article : Google Scholar : PubMed/NCBI
18	De Vita A, Mercatali L, Recine F, Pieri F, Riva N, Bongiovanni A, Liverani C, Spadazzi C, Miserocchi G, Amadori D, et al: Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas. Onco Targets Ther. 9:6233–6246. 2016. View Article : Google Scholar : PubMed/NCBI
19	Evans HL: Liposarcoma: A study of 55 cases with a reassessment of its classification. Am J Surg Patho. 3:507–523. 1970. View Article : Google Scholar
20	Singer S, Antonescu CR, Riedel E and Brennan MF: Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 238:358–370. 2003.PubMed/NCBI
21	Murphey MD, Arcara LK and Fanburg-Smith J: Imaging of Musculoskeletal Liposarcoma with radiologic-pathologic correlation. RadioGraphics. 25:1371–1395. 2005. View Article : Google Scholar : PubMed/NCBI
22	Kito M, Yoshimura Y, Isobe K, Aoki K, Suzuki S, Tanaka A, Okamoto M, Sano K and Kato H: Clinical outcome of dedifferentiated liposarcoma in the extremities: A retrospective case series of 7 patients. J Orthop Sci. 21:673–677. 2016. View Article : Google Scholar : PubMed/NCBI
23	Aiken AH: Imaging of thyroid cancer. Semin Ultrasound CT MR. 33:138–149. 2012. View Article : Google Scholar : PubMed/NCBI