Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis

  • Authors:
    • Shi‑Ji Xiao
    • Jian‑Zhen Shen
    • Jin‑Long Huang
    • Hai-Ying Fu
  • View Affiliations

  • Published online on: May 11, 2015     https://doi.org/10.3892/mco.2015.562
  • Pages: 880-888
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Numerous studies have investigated the prognostic role of brain and acute leukemia, cytoplasmic (BAALC) gene expression in adult patients with acute myeloid leukemia (AML); however, the results are inconclusive. A meta‑analysis was conducted to provide a comprehensive evaluation of the prognostic role of BAALC gene expression in AML. Eligible studies were searched through PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure and the China Biology Medicine Disc. Correlations between the BAALC gene expression and clinicopathological features and prognosis were analyzed. A total of 15 studies were examined. The pooled results suggest that high BAALC expression had an unfavorable outcome in AML. The combined hazard ratio (HR) for overall survival (OS) was 1.53 and the summary HR for the disease‑free survival rate was 1.64. In addition, subgroup analyses considering cytogenetic and survival analysis were also conducted. High BAALC gene expression appeared to be an adverse prognostic indicator in patients with cytogenetically normal AML (HR for OS, 1.43) and in subgroups of survival analysis with multivariate analysis (HR for OS, 2.35). These results indicate that high BAALC gene expression served as an independent poor prognostic indicator in adult patients with AML.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 3 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xiao SJ, Shen JZ, Huang JL and Fu H: Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis. Mol Clin Oncol 3: 880-888, 2015
APA
Xiao, S., Shen, J., Huang, J., & Fu, H. (2015). Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis. Molecular and Clinical Oncology, 3, 880-888. https://doi.org/10.3892/mco.2015.562
MLA
Xiao, S., Shen, J., Huang, J., Fu, H."Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 3.4 (2015): 880-888.
Chicago
Xiao, S., Shen, J., Huang, J., Fu, H."Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 3, no. 4 (2015): 880-888. https://doi.org/10.3892/mco.2015.562