Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)
- Authors:
- Cheng‑Xian Guo
- Jing Wang
- Li‑Hua Huang
- Jin-Gao Li
- Xiang Chen
-
Affiliations: Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China - Published online on: October 30, 2015 https://doi.org/10.3892/mco.2015.666
- Pages: 3-10
This article is mentioned in:
Abstract
 |
|
Arpin D, Mahé MA, Servois V and Claude L: Predictive factors for acute radiation pneumonitis. Rev Pneumol Clin. 65:177–186. 2009.(In French). View Article : Google Scholar : PubMed/NCBI | |
|
Yamashita H, Nakagawa K, Nakamura N, et al: Exceptionally high incidence of symptomatic grade 2–5 radiation pneumonitis after stereotactic radiation therapy for lung tumors. Radiat Oncol. 2:212007. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang XJ, Sun JG, Sun J, et al: Prediction of radiation pneumonitis in lung cancer patients: A systematic review. J Cancer Res Clin Oncol. 138:2103–2116. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Giuliani ME, Lindsay PE, Kwan JY, et al: Correlation of dosimetric and clinical factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma. Clin Lung Cancer. 16:216–220. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Dang J, Li G, Zang S, Zhang S and Yao L: Comparison of risk and predictors for early radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with radiotherapy with or without surgery. Lung Cancer. 86:329–333. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tsujino K, Hashimoto T, Shimada T, et al: Combined analysis of V20, VS5, pulmonary fibrosis score on baseline computed tomography and patient age improves prediction of severe radiation pneumonitis after concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer. J Thorac Oncol. 9:983–990. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Dang J, Li G, Zang S, Zhang S and Yao L: Risk and predictors for early radiation pneumonitis in patients with stage III non-small cell lung cancer treated with concurrent or sequential chemoradiotherapy. Radiat Oncol. 9:1722014. View Article : Google Scholar : PubMed/NCBI | |
|
Siva S, MacManus M, Kron T, et al: A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer. PLoS One. 9:e1095602014. View Article : Google Scholar : PubMed/NCBI | |
|
Johnston CJ, Williams JP, Elder A, Hernady E and Finkelstein JN: Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 30:369–382. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Pappas PJ, You R, Rameshwar P, et al: Dermal tissue fibrosis in patients with chronic venous insufficiency is associated with increased transforming growth factor-beta1 gene expression and protein production. J Vasc Surg. 30:1129–1145. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Qi W, Twigg S, Chen X, et al: Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. Am J Physiol Renal Physiol. 288:F800–F809. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Oberringer M, Meins C, Bubel M and Pohlemann T: In vitro wounding: Effects of hypoxia and transforming growth factor beta1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model. J Mol Histol. 39:37–47. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Anscher MS, Kong FM, Αndrews K, et al: Plasma transforming growth factor beta1 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 41:1029–1035. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan X, Liao Z, Liu Z, et al: Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. J Clin Oncol. 27:3370–3378. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L and Bi N: TGF-beta1 gene polymorphisms for anticipating radiation-induced pneumonitis in non-small-cell lung cancer: Different ethnic association. J Clin Oncol. 28:e621–e622. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Niu X, Li H, Chen Z, et al: A study of ethnic differences in TGFβ1 gene polymorphisms and effects on the risk of radiation pneumonitis in non-small-cell lung cancer. J Thorac Oncol. 7:1668–1675. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Qin R, Zhou J, Chen C, et al: LIN28 is involved in glioma carcinogenesis and predicts outcomes of glioblastoma multiforme patients. PLoS One. 9:e864462014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Zhu L, Wang R, et al: Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han population. Sci Rep. 4:74342014. View Article : Google Scholar : PubMed/NCBI | |
|
Iliopoulos D, Hirsch HA and Struhl K: An epigenetic switch involving NF-kappaB, Lin28, Let-7 microRNA and IL6 links inflammation to cell transformation. Cell. 139:693–706. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Mayr F and Heinemann U: Mechanisms of Lin28-mediated miRNA and mRNA regulation - a structural and functional perspective. Int J Mol Sci. 14:16532–16553. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Oh JS, Kim JJ, Byun JY and Kim IA: Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras. Int J Radiat Oncol Biol Phys. 76:5–8. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wen J, Liu H, Wang Q, et al: Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Eur J Cancer. 50:1706–1716. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hildebrandt MA, Komaki R, Liao Z, et al: Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. PLoS One. 5:e124022010. View Article : Google Scholar : PubMed/NCBI | |
|
Pu X, Wang L, Chang JY, et al: Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer. Clin Pharmacol Ther. 96:609–615. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hubenak JR, Zhang Q, Branch CD and Kronowitz SJ: Mechanisms of injury to normal tissue after radiotherapy: A review. Plast Reconstr Surg. 133:49e–56e. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hornhardt S, Rößler U, Sauter W, et al: Genetic factors in individual radiation sensitivity. DNA repair (Amst). 16:54–65. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Patrono C, Sterpone S, Testa A and Cozzi R: Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity. World J Clin Oncol. 5:874–882. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Shiloh Y: ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer. 3:155–168. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Su D, Ma S, Liu P, et al: Genetic polymorphisms and treatment response in advanced non-small cell lung cancer. Lung Cancer. 56:281–288. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Bakkenist CJ and Kastan MB: DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499–506. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Worgul BV, Smilenov L, Brenner DJ, Junk A, Zhou W and Hall EJ: Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc Natl Acad Sci USA. 99:9836–9839. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Wang SC, Wu CC, Wei YY, Hong JH and Chiang CS: Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. Int J Radiat Biol. 87:432–442. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Yang M, Bi N, et al: ATM polymorphisms are associated with risk of radiation-induced pneumonitis. Int J Radiat Oncol Biol Phys. 77:1360–1368. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yang M, Zhang L, Bi N, et al: Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 79:1402–1407. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong H, Liao Z, Liu Z, et al: ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Int J Radiat Oncol Biol Phys. 85:1066–1073. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Srivastava M and Raghavan SC: DNA double-strand break repair inhibitors as cancer therapeutics. Chem Biol. 22:17–29. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yin M, Liao Z, Huang YJ, et al: Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy. PLoS One. 6:e200552011. View Article : Google Scholar : PubMed/NCBI | |
|
Yin M, Liao Z, Liu Z, et al: Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy. Cancer. 118:528–535. 2012. | |
|
Tell G, Fantini D and Quadrifoglio F: Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment. Cell Mol Life Sci. 67:3589–3608. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yin M, Liao Z, Liu Z, et al: Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Int J Radiat Oncol Biol Phys. 81:e67–e73. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Li H, Liu G, Xia L, et al: A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy. Br J Radiol. 87:201400932014. View Article : Google Scholar : PubMed/NCBI | |
|
Taricani L, Shanahan F, Pierce RH, Guzi TJ and Parry D: Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase. Cell Cycle. 9:4876–4883. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Zhu M, Zhang Z, et al: A NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy. Cancer. 119:4205–4211. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Cadet J and Wagner JR: DNA base damage by reactive oxygen species, oxidizing agents and UV radiation. Cold Spring Harb Perspect Biol. 5:a0125592013. View Article : Google Scholar : PubMed/NCBI | |
|
Kim YW and Byzova TV: Oxidative stress in angiogenesis and vascular disease. Blood. 123:625–631. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Mittal M, Siddiqui MR, Tran K, Reddy SP and Malik AB: Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 20:1126–1167. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Stankova J, Lawrance AK and Rozen R: Methylenetetrahydrofolate reductase (MTHFR): A novel target for cancer therapy. Curr Pharm Des. 14:1143–1150. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Mak RH, Alexander BM, Asomaning K, et al: A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy. Cancer. 118:3654–3665. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mymrikov EV, Seit-Nebi AS and Gusev NB: Large potentials of small heat shock proteins. Physiol Rev. 91:1123–1159. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Laskowska E: Small heat shock proteins-role in apoptosis, cancerogenesis and diseases associated with protein aggregation. Postepy Biochem. 53:19–26. 2007.(In Polish). PubMed/NCBI | |
|
Schmid TE and Multhoff G: Radiation-induced stress proteins - the role of heat shock proteins (HSP) in anti-tumor responses. Curr Med Chem. 19:1765–1770. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Arrigo AP, Virot S, Chaufour S, et al: Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels. Antioxid Redox Signal. 7:414–422. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Pang Q, Wei Q, Xu T, et al: Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 85:1332–1339. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Medinger M and Passweg J: Angiogenesis in myeloproliferative neoplasms, new markers and future directions. Memo. 7:206–210. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Mittal K, Ebos J and Rini B: Angiogenesis and the tumor microenvironment: Vascular endothelial growth factor and beyond. Semin Oncol. 41:235–251. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 29(Suppl 16): 15–18. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Lum H and Roebuck KA: Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 280:C719–C741. 2001.PubMed/NCBI | |
|
Fisher M: Injuries to the vascular endothelium: Vascular wall and endothelial dysfunction. Rev Neurol Dis. 5(Suppl 1): S4–S11. 2008.PubMed/NCBI | |
|
Anbalagan D, Yap G, Yuan Y, et al: Annexin-A1 regulates microRNA-26b* and microRNA-562 to directly target NF-κB and angiogenesis in breast cancer cells. PLoS One. 9:e1145072014. View Article : Google Scholar : PubMed/NCBI | |
|
Yin M, Liao Z, Yuan X, et al: Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy. Cancer Sci. 103:945–950. 2012. | |
|
Kelsey CR, Jackson L, Langdon S, et al: A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint. Int J Radiat Oncol Biol Phys. 82:e247–e255. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
De Ruysscher D, Sharifi H, Defraene G, et al: Quantification of radiation-induced lung damage with CT scans: The possible benefit for radiogenomics. Acta Oncol. 52:1405–1410. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kerns SL, West CM, Andreassen CN, et al: Radiogenomics: The search for genetic predictors of radiotherapy response. Future Oncol. 10:2391–2406. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kerns SL, Ostrer H and Rosenstein BS: Radiogenomics: Using genetics to identify cancer patients at risk for development of adverse effects following radiotherapy. Cancer Discov. 4:155–165. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Burnet NG, Barnett GC, Elliott RM, Dearnaley DP, Pharoah PD, Dunning AM, West CM and Investigators R: RAPPER Investigators: RAPPER: The radiogenomics of radiation toxicity. Clin Oncol (R Coll Radiol). 25:431–434. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
West C, Rosenstein BS, Alsner J, et al: EQUAL-ESTRO: Establishment of a Radiogenomics Consortium. Int J Radiat Oncol Biol Phys. 76:1295–1296. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Borchiellini D, Etienne-Grimaldi MC, Thariat J and Milano G: The impact of pharmacogenetics on radiation therapy outcome in cancer patients. A focus on DNA damage response genes. Cancer Treat Rev. 38:737–759. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Barnett GC, Thompson D, Fachal L, et al: A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Radiother Oncol. 111:178–185. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kerns SL, Stock R, Stone N, et al: A two-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of erectile dysfunction following radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 85:e21–e28. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Manolio TA: Bringing genome-wide association findings into clinical use. Nat Rev Genet. 14:549–558. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Tuzun E, Sharp AJ, Bailey JA, et al: Fine-scale structural variation of the human genome. Nat Genet. 37:727–732. 2005. View Article : Google Scholar : PubMed/NCBI |
