Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney

  • Authors:
    • Shunsuke Orisaka
    • Kyosuke Kagami
    • Yasunari Mizumoto
    • Wataru Koda
    • Masanori Ono
    • Mitsuhiro Nakamura
    • Hiroshi Fujiwara
  • View Affiliations

  • Published online on: October 18, 2017     https://doi.org/10.3892/mco.2017.1460
  • Pages:1057-1060
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Abstract

The current report describes a case of extragenital gestational choriocarcinoma in the kidney. A 36‑year‑old woman with a history of two deliveries of male babies visited the present hospital due to secondary amenorrhea following a positive urinary pregnancy test. Despite a high serum level of human chorionic gonadotropin, at 51,800 mIU/ml, diagnostic imaging methods and pathological examination did not detect any conceptus in the genital tract. Positron emission tomography‑computed tomography detected 18F‑FDG‑positive tumors in the left kidney and right lung. A fine needle biopsy of the renal lesion pathologically revealed the presence of choriocarcinoma and a subsequent polymerase chain reaction analysis verified the presence of a Y‑chromosome‑specific the sex‑determining region Y (SRY) gene, diagnosed as extragenital gestational choriocarcinoma. Clinically, 10 cycles of EMA/CO chemotherapy were administered and an optimal response was obtained. In conclusion, this is the first report of the diagnosis of extragenital gestational choriocarcinoma by the detection of the SRY gene with PCR using biopsy samples.

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December 2017
Volume 7 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Orisaka, S., Kagami, K., Mizumoto, Y., Koda, W., Ono, M., Nakamura, M., & Fujiwara, H. (2017). Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney. Molecular and Clinical Oncology, 7, 1057-1060. https://doi.org/10.3892/mco.2017.1460
MLA
Orisaka, S., Kagami, K., Mizumoto, Y., Koda, W., Ono, M., Nakamura, M., Fujiwara, H."Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney". Molecular and Clinical Oncology 7.6 (2017): 1057-1060.
Chicago
Orisaka, S., Kagami, K., Mizumoto, Y., Koda, W., Ono, M., Nakamura, M., Fujiwara, H."Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney". Molecular and Clinical Oncology 7, no. 6 (2017): 1057-1060. https://doi.org/10.3892/mco.2017.1460