Open Access

Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma

  • Authors:
    • Kohei Nakamura
    • Kentaro Nakayama
    • Nagisa Tatsumi
    • Toshiko Minamoto
    • Tomoka Ishibashi
    • Kaori Ohnishi
    • Hitomi Yamashita
    • Ruriko Ono
    • Hiroki Sasamori
    • Sultana Razia
    • Shanta Kamrunnahar
    • Masako Ishikawa
    • Satoru Kyo
  • View Affiliations

  • Published online on: June 5, 2018     https://doi.org/10.3892/mco.2018.1646
  • Pages: 138-144
  • Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to assess the prognostic significance of the pre‑treatment neutrophil‑to‑lymphocyte ratio (NLR), the platelet‑to‑lymphocyte ratio (PLR) and other clinicopathological characteristics in patients with non‑surgically treated uterine cervical carcinoma. The correlations of clinicopathological characteristics with overall and progression‑free survival were determined in 98 Japanese patients who received non‑surgical treatment for uterine cervical carcinoma between January 1997 and July 2013. Survival rates were calculated using the Kaplan‑Meier method and potential prognostic indicators were assessed using a Cox proportional hazards model. A total of 68 patients (69.4%) had a high pre‑treatment NLR (≥3.5) and 34 patients (34.7%) had a high pre‑treatment PLR (≥212). Both NLR and PLR were found to be positively correlated with pre‑treatment platelet counts. Multivariate analysis identified NLR and carcinoembryonic antigen level, but not PLR, as independent predictors of overall and progression‑free survival. In conclusion, the present study identified two prognostic indicators for uterine cervical carcinoma, both of which can be easily and cost‑effectively monitored via blood testing.
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August-2018
Volume 9 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Nakamura K, Nakayama K, Tatsumi N, Minamoto T, Ishibashi T, Ohnishi K, Yamashita H, Ono R, Sasamori H, Razia S, Razia S, et al: Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma. Mol Clin Oncol 9: 138-144, 2018
APA
Nakamura, K., Nakayama, K., Tatsumi, N., Minamoto, T., Ishibashi, T., Ohnishi, K. ... Kyo, S. (2018). Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma. Molecular and Clinical Oncology, 9, 138-144. https://doi.org/10.3892/mco.2018.1646
MLA
Nakamura, K., Nakayama, K., Tatsumi, N., Minamoto, T., Ishibashi, T., Ohnishi, K., Yamashita, H., Ono, R., Sasamori, H., Razia, S., Kamrunnahar, S., Ishikawa, M., Kyo, S."Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma". Molecular and Clinical Oncology 9.2 (2018): 138-144.
Chicago
Nakamura, K., Nakayama, K., Tatsumi, N., Minamoto, T., Ishibashi, T., Ohnishi, K., Yamashita, H., Ono, R., Sasamori, H., Razia, S., Kamrunnahar, S., Ishikawa, M., Kyo, S."Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma". Molecular and Clinical Oncology 9, no. 2 (2018): 138-144. https://doi.org/10.3892/mco.2018.1646