Open Access

Anti‑carcinogenic activity of anandamide on human glioma in vitro and in vivo

  • Authors:
    • Chao Ma
    • Ting‑Ting Wu
    • Pu‑Cha Jiang
    • Zhi‑Qiang Li
    • Xin‑Jun Chen
    • Kai Fu
    • Wei Wang
    • Rui Gong
  • View Affiliations

  • Published online on: December 28, 2015     https://doi.org/10.3892/mmr.2015.4721
  • Pages: 1558-1562
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The poor prognosis of gliomas is to a large extent attributed to the markedly proliferative and invasive nature of the disease. Endocannabinoids have emerged as novel potential anti‑tumor agents. The present study aimed to investigate the anti‑carcinogenic activity of anandamide (AEA), an endocannabinoid, on glioma cells. To assess the functional role of AEA in glioma, the effects of AEA on cell proliferation, migration, invasion, apoptosis and the cell cycle in vitro, and tumor growth in vivo, were investigated. AEA markedly inhibited the proliferation of U251 cells in a dose‑ and time‑dependent manner. Flow cytometric assays revealed that the apoptosis rate of U251 cells upon treatment with AEA was increased. AEA also suppressed the adhesion, migration and invasion capabilities of the U251 cells. Furthermore, AEA inhibited tumor growth in vivo. These results highlighted the potential role of AEA in the tumorigenesis and progression of glioma, and suggested that AEA exhibits therapeutic potential in the management of human glioma.

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February 2016
Volume 13 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Ma, C., Wu, T., Jiang, P., Li, Z., Chen, X., Fu, K. ... Gong, R. (2016). Anti‑carcinogenic activity of anandamide on human glioma in vitro and in vivo. Molecular Medicine Reports, 13, 1558-1562. https://doi.org/10.3892/mmr.2015.4721
MLA
Ma, C., Wu, T., Jiang, P., Li, Z., Chen, X., Fu, K., Wang, W., Gong, R."Anti‑carcinogenic activity of anandamide on human glioma in vitro and in vivo". Molecular Medicine Reports 13.2 (2016): 1558-1562.
Chicago
Ma, C., Wu, T., Jiang, P., Li, Z., Chen, X., Fu, K., Wang, W., Gong, R."Anti‑carcinogenic activity of anandamide on human glioma in vitro and in vivo". Molecular Medicine Reports 13, no. 2 (2016): 1558-1562. https://doi.org/10.3892/mmr.2015.4721