Open Access

Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma

  • Authors:
    • Lei Wang
    • Chen Chen
    • Fen Li
    • Qing‑Quan Hua
    • Shiming Chen
    • Bokui Xiao
    • Mengyuan Dai
    • Man Li
    • Anyuan Zheng
    • Di Yu
    • Zhang Wei Hu
    • Zezhang Tao
  • View Affiliations

  • Published online on: May 27, 2016     https://doi.org/10.3892/mmr.2016.5347
  • Pages: 1075-1082
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Regional metastasis is an important prognostic factor for patients with head and neck squamous cell carcinoma (HNSCC). Neuromedin U (Nmu) is a secreted neuropeptide, named due to its potent uterine contraction‑inducing activity. The aim of the present study was to analyze the significance of Nmu in the regional metastasis of HNSCC. The characteristics of 240 patients recruited from the Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University (Wuhan, China) were summarized retrospectively. The positive rate of neck dissection was analyzed according to the material. The expression levels of Nmu in human tumor samples were analyzed using immunohistochemistry. Subsequently, the expression of Nmu was investigated using a tissue microassay to analyze the association between Nmu protein expression and Tumor Node Metastasis (TNM) status. The positive rate of neck dissection was 51.4% in the study sample. The expression levels of Nmu in primary tumors with regional metastasis were higher, compared with those without metastasis. There was increased protein expression of Nmu in the advanced tumor tissues. The data obtained in the present study demonstrated that the expression of Nmu was correlated with regional metastasis and TNM status. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC.
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August-2016
Volume 14 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang L, Chen C, Li F, Hua QQ, Chen S, Xiao B, Dai M, Li M, Zheng A, Yu D, Yu D, et al: Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma. Mol Med Rep 14: 1075-1082, 2016
APA
Wang, L., Chen, C., Li, F., Hua, Q., Chen, S., Xiao, B. ... Tao, Z. (2016). Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma. Molecular Medicine Reports, 14, 1075-1082. https://doi.org/10.3892/mmr.2016.5347
MLA
Wang, L., Chen, C., Li, F., Hua, Q., Chen, S., Xiao, B., Dai, M., Li, M., Zheng, A., Yu, D., Hu, Z. W., Tao, Z."Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma". Molecular Medicine Reports 14.2 (2016): 1075-1082.
Chicago
Wang, L., Chen, C., Li, F., Hua, Q., Chen, S., Xiao, B., Dai, M., Li, M., Zheng, A., Yu, D., Hu, Z. W., Tao, Z."Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma". Molecular Medicine Reports 14, no. 2 (2016): 1075-1082. https://doi.org/10.3892/mmr.2016.5347