Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease

Wu,Shizheng; Hao,Guisheng; Zhang,Shukun; Jiang,Dongmei; Wuren,Tana; Luo,Junming

doi:10.3892/mmr.2016.5555

Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease

Authors:
- Shizheng Wu
- Guisheng Hao
- Shukun Zhang
- Dongmei Jiang
- Tana Wuren
- Junming Luo
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Affiliations: Department of Neurology, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, P.R. China, Department of Pathology, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, P.R. China, Research Center for High Altitude Medicine, Qinghai University, Xining, Qinghai 810001, P.R. China
Published online on: July 27, 2016 https://doi.org/10.3892/mmr.2016.5555
Pages: 2497-2502
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to examine cerebral vasoconstriction in patients with chronic high altitude disease [cerebrovascular reactivity (CVR)], and to evaluate differences in alterations of brain vascular contractile reactivity of chronic mountain sickness (CMS) patients and healthy controls. Alterations of endothelin (ET) and its receptor, as well as endothelial nitric oxide synthase (eNOS) levels in the plasma were examined to determine the cerebral reservation capacities in CMS patients. Transcranial Doppler ultrasound and carbon dioxide analysis methods were used to detect the CVR variances. At the same time, enzyme‑linked immunosorbent assay approaches were utilized to detect the ET and ET B receptor and the eNOS levels in serum of the CMS patients and healthy controls. CVR and CVRI levels in CMS patients were lower than those of the healthy control subjects and the difference was statistically significant (P<0.05). By contrast, eNOS and ET‑1 levels were not statistically significant for CMS and healthy controls (P>0.05). However, the ET receptor concentration level was higher in CMS than the healthy controls. Thus, ET‑1 may not be a direct etiological variation but may play compensatory roles in CMS patients. The results of the study may provide scientific clues for the prevention and treatment of CMS with higher blood coagulation states of cerebral infarction in patients with chronic high altitude disease.

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