Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities

  • Authors:
    • Jun Peng
    • Xingfeng Ren
    • Tianbiao Lan
    • Yan Chen
    • Ziyun Shao
    • Cheng Yang
  • View Affiliations

  • Published online on: August 19, 2016     https://doi.org/10.3892/mmr.2016.5654
  • Pages: 3397-3402
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Abstract

Ursolic acid, a pentacyclic triterpene compound with low toxicity and easy availability, has a variety of biological activities, including antitumor, antioxidant, antihepatitis, anti‑inflammatory and antibacterial effects. The present study aimed to investigate the renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury (I/R‑IAKI) in rats associated with its antioxidant and anti‑inflammatory effects, as well as interference with the signal transducer and activator of transcription (STAT)3/nuclear factor (NF)‑κB signaling pathway. The present study demonstrated that pre‑treatment with ursolic acid significantly increased renal functioning and attenuated increases of serum angiotensin II levels in rats subjected to I/R‑IAKI. In addition, I/R‑IAKI‑induced inflammation and oxidative stress were significantly reduced by pre‑treatment with ursolic acid. Furthermore, ursolic acid significantly suppressed the upregulation of STAT3, NF‑κB and caspase‑3 activities in rats following I/R‑IAKI. These results indicated that ursolic acid may be a potential drug for reducing I/R‑IAKI through suppression of inflammation and oxidative stress damage, as well as modulation of STAT3 and NF‑κB activities.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Peng J, Ren X, Lan T, Chen Y, Shao Z and Yang C: Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities. Mol Med Rep 14: 3397-3402, 2016
APA
Peng, J., Ren, X., Lan, T., Chen, Y., Shao, Z., & Yang, C. (2016). Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities. Molecular Medicine Reports, 14, 3397-3402. https://doi.org/10.3892/mmr.2016.5654
MLA
Peng, J., Ren, X., Lan, T., Chen, Y., Shao, Z., Yang, C."Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities". Molecular Medicine Reports 14.4 (2016): 3397-3402.
Chicago
Peng, J., Ren, X., Lan, T., Chen, Y., Shao, Z., Yang, C."Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities". Molecular Medicine Reports 14, no. 4 (2016): 3397-3402. https://doi.org/10.3892/mmr.2016.5654