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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2016 Volume 14 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Notch signaling in cerebrovascular diseases (Review)

Zhiyou Cai, Bin Zhao, Yanqing Deng, Shouqin Shangguan, Faming Zhou, Wenqing Zhou, Xiaoli Li, Yanfeng Li, Guanghui Chen
Pages: 2883-2898
Published online on: 19 August 2016

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Review Open Access

Endocannabinoid system: Role in depression, reward and pain control (Review)

Wen‑Juan Huang, Wei‑Wei Chen, Xia Zhang
Pages: 2899-2903
Published online on: 01 August 2016

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Article Open Access

Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phase

Peiyan Liu, Yueling Sun, Guangbin Qiu, Hongkun Jiang, Guangrong Qiu
Pages: 2904-2914
Published online on: 19 August 2016

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Article Open Access

A novel variant of androgen receptor is associated with idiopathic azoospermia

Lisha Mou, Yaoting Gui
Pages: 2915-2920
Published online on: 04 August 2016

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Article Open Access

Inhibitory effect of metformin combined with gemcitabine on pancreatic cancer cells in vitro and in vivo

Yuqi Shi, Zhilong He, Zhenyu Jia, Chunfang Xu
Pages: 2921-2928
Published online on: 04 August 2016

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Article Open Access

Sonic hedgehog protein regulates fibroblast growth factor 8 expression in metanephric explant culture from BALB/c mice: Possible mechanisms associated with renal morphogenesis

Xing Chen, Xiao‑Ming Hou, You‑Fei Fan, Yu‑Ting Jin, Yu‑Lin Wang
Pages: 2929-2936
Published online on: 09 August 2016

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Article Open Access

Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line

Jae Hyoung Song, Mei Jing Piao, Xia Han, Kyoung Ah Kang, Hee Kyoung Kang, Weon Jong Yoon, Mi Hee Ko, Nam Ho Lee, Mi Young Lee, Sungwook Chae, Jin Won Hyun
Pages: 2937-2944
Published online on: 19 August 2016

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Article Open Access

Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophages

Hui Yan, Shuai Wang, Zhenwei Li, Zewei Sun, Jie Zan, Wenting Zhao, Yanyun Pan, Zhen Wang, Mingjie Wu, Jianhua Zhu
Pages: 2945-2952
Published online on: 19 August 2016

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Article Open Access

Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma

Min Ye, Qundan Wu, Min Zhang, Jinbei Huang
Pages: 2953-2958
Published online on: 08 August 2016

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Article Open Access

Nicotinic α7 receptor inhibits the acylation stimulating protein‑induced production of monocyte chemoattractant protein‑1 and keratinocyte‑derived chemokine in adipocytes by modulating the p38 kinase and nuclear factor‑κB signaling pathways

Zhou‑Yang Jiao, Jing Wu, Chao Liu, Bing Wen, Wen‑Zeng Zhao, Xin‑Ling Du
Pages: 2959-2966
Published online on: 12 August 2016

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Article Open Access

A technical application of quantitative next generation sequencing for chimerism evaluation

Michelangelo Aloisio, Danilo Licastro, Luciana Caenazzo, Valentina Torboli, Angela D'Eustacchio, Giovanni Maria Severini, Emmanouil Athanasakis
Pages: 2967-2974
Published online on: 04 August 2016

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Article Open Access

miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer

Liangfeng Guo, Jianhui Yuan, Ni Xie, Huisheng Wu, Weicai Chen, Shufen Song, Xianming Wang
Pages: 2975-2982
Published online on: 19 August 2016

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Article Open Access

Toll‑like receptor 4 contributes to acute kidney injury after cardiopulmonary resuscitation in mice

Qingsong Zhang, Gang Li, Li Xu, Qian Li, Qianyan Wang, Yue Zhang, Qing Zhang, Peng Sun
Pages: 2983-2990
Published online on: 08 August 2016

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Article Open Access

Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma

Zhi‑Yuan Deng, Yue‑Hong Wang, Hong‑Zhi Quan, Ou‑Sheng Liu, Yi‑Ping Li, Yuan Li, Wu Zhu, Krishna Munnee, Zhan‑Gui Tang
Pages: 2991-2996
Published online on: 09 August 2016

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Article Open Access

FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis

Hua Qian, Xiaoyue Guan, Zhuan Bian
Pages: 2997-3006
Published online on: 09 August 2016

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Article Open Access

Quantum dot-based molecular imaging of cancer cell growth using a clone formation assay

Xia‑Fei Geng, Min Fang, Shao‑Ping Liu, Yan Li
Pages: 3007-3012
Published online on: 18 August 2016

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Article Open Access

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death

Ruichao Huo, Lili Wang, Peijuan Liu, Yong Zhao, Caiqin Zhang, Bing Bai, Xueying Liu, Changhong Shi, Sanhua Wei, Hai Zhang
Pages: 3013-3020
Published online on: 19 August 2016

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Article Open Access

MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma

Li Qian, Longlong Lin, Yufeng Du, Xiaoyan Hao, Yuze Zhao, Xuejun Liu
Pages: 3021-3028
Published online on: 19 August 2016

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Article Open Access

Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation

Miran Yoo, Sang‑Jin Lee, Yong Kee Kim, Dong‑Wan Seo, Nam‑In Baek, Jae‑Ha Ryu, Jong‑Sun Kang, Gyu‑Un Bae
Pages: 3029-3036
Published online on: 19 August 2016

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Article Open Access

Effect of autophagy induced by dexamethasone on senescence in chondrocytes

Enxing Xue, Yu Zhang, Bing Song, Jun Xiao, Zhanjun Shi
Pages: 3037-3044
Published online on: 22 August 2016

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Article Open Access

Human tonsil‑derived mesenchymal stromal cells enhanced myelopoiesis in a mouse model of allogeneic bone marrow transplantation

Jung‑Hwa Ryu, Minhwa Park, Bo‑Kyung Kim, Yu‑Hee Kim, So‑Youn Woo, Kyung‑Ha Ryu
Pages: 3045-3051
Published online on: 08 August 2016

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Article Open Access

Analysis of gene expression profile identifies potential biomarkers for atherosclerosis

Luran Liu, Yan Liu, Chang Liu, Zhuobo Zhang, Yaojun Du, Hao Zhao
Pages: 3052-3058
Published online on: 19 August 2016

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Article Open Access

Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells

Wen‑Xiang Li, Meng‑Xuan Yang, Xin‑Qiang Hong, Tian‑Geng Dong, Tuo Yi, Sheng‑Li Lin, Xin‑Yu Qin, Wei‑Xin Niu
Pages: 3059-3065
Published online on: 19 August 2016

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Article Open Access

Possible role of the Ec peptide of IGF‑1Ec in cartilage repair

Nikolaos Armakolas, Andreas Dimakakos, Athanasios Armakolas, Athanasios Antonopoulos, Michael Koutsilieris
Pages: 3066-3072
Published online on: 12 August 2016

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Article Open Access

Impact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats

Yani Liu, Xiaomei Luo, Chunxiao Yang, Tingyu Yang, Jiali Zhou, Shaojun Shi
Pages: 3073-3085
Published online on: 09 August 2016

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Article Open Access

Allicin protects traumatic spinal cord injury through regulating the HSP70/Akt/iNOS pathway in mice

Shunyi Wang, Dongliang Ren
Pages: 3086-3092
Published online on: 19 August 2016

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Article Open Access

Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice

Myung Ah Kang, Se‑Young Choung
Pages: 3093-3103
Published online on: 08 August 2016

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Article Open Access

Mesenchymal stem cells in corneal neovascularization: Comparison of different application routes

Emma Ghazaryan, Yan Zhang, Yuxi He, Xin Liu, Ying Li, Jianan Xie, Guanfang Su
Pages: 3104-3112
Published online on: 11 August 2016

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Article Open Access

The study on mechanism of the modified Chinese herbal compound, jianpijiedu, on a mouse model of hepatic carcinoma cachexia

Baoguo Sun, Haoxuan Luo, Liuxiang Deng, Shijun Zhang, Zexiong Chen
Pages: 3113-3121
Published online on: 08 August 2016

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Article Open Access

Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice

Hui Han, Yanjia Chen, Jinzhou Zhu, Jingwei Ni, Jiateng Sun, Ruiyan Zhang
Pages: 3122-3128
Published online on: 12 August 2016

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Article Open Access

A novel missense mutation of the GRK1 gene in Oguchi disease

Mehmet Yasin Teke, Mehmet Citirik, Serkan Kabacam, Suleyman Demircan, Mehmet Alikasifoglu
Pages: 3129-3133
Published online on: 09 August 2016

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Article Open Access

Reprogramming A375 cells to induced‑resembled neuronal cells by structured overexpression of specific transcription genes

Hengzhu Zhang, Min Wei, Yangyang Jiang, Xiaodong Wang, Lei She, Zhengcun Yan, Lun Dong, Lujun Pang, Xingdong Wang
Pages: 3134-3144
Published online on: 08 August 2016

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Article Open Access

KIF21A mutation in two Chinese families with congenital fibrosis of the extraocular muscles type 1 and 3

Jingchang Chen, Qingqing Ye, Daming Deng, Jianhua Yan, Houbian Lin, Tao Shen, Ying Lin
Pages: 3145-3151
Published online on: 11 August 2016

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Article Open Access

Hypolipidemic effects of HVC1 in a high cholesterol diet‑induced rat model of hyperlipidemia

Chae‑Yun Kim, Kyung‑Sook Chung, Se‑Yun Cheon, Kyungjin Lee, Inhye Ham, Ho‑Young Choi, Yong Baik Cho, Byoung‑Heon Cho, So Youn Mok, Hyo‑Jin An
Pages: 3152-3158
Published online on: 09 August 2016

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Article Open Access

Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancer

Guanghu Li, Yufei Gao, Yongsheng Cui, Tao Zhang, Rui Cui, Yang Jiang, Jingwei Shi
Pages: 3159-3167
Published online on: 18 August 2016

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Article Open Access

Identification of distinct genes associated with seawater aspiration‑induced acute lung injury by gene expression profile analysis

Wei Liu, Lei Pan, Minlong Zhang, Liyan Bo, Congcong Li, Qingqing Liu, Li Wang, Faguang Jin
Pages: 3168-3178
Published online on: 09 August 2016

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Article Open Access

Natural compound oblongifolin C inhibits autophagic flux, and induces apoptosis and mitochondrial dysfunction in human cholangiocarcinoma QBC939 cells

Aiqing Zhang, Wei He, Huimin Shi, Xiaodan Huang, Guozhong Ji
Pages: 3179-3183
Published online on: 04 August 2016

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Article Open Access

Potential fluid biomarkers for pathological brain changes in Alzheimer's disease: Implication for the screening of cognitive frailty

Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Zhuowei Yu
Pages: 3184-3198
Published online on: 09 August 2016

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Article Open Access

Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP‑2/9 production via the p38 MAPK signaling pathway

Gong Cheng, Fengguang Gao, Xiujiang Sun, Haiyong Bi, Yonglin Zhu
Pages: 3199-3205
Published online on: 22 August 2016

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Article Open Access

Ameliorative effects of Artemisia argyi Folium extract on 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like lesions in BALB/c mice

Hyoung‑Min Han, Seung‑Ju Kim, Jong‑Sik Kim, Bum Hoi Kim, Hai Woong Lee, Yong Tae Lee, Kyung‑Hwa Kang
Pages: 3206-3214
Published online on: 19 August 2016

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Article Open Access

Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampus

Jin‑A Park, Joon Ha Park, Ji Hyeon Ahn, Jong‑Dai Kim, Moo‑Ho Won, Choong‑Hyun Lee
Pages: 3215-3219
Published online on: 09 August 2016

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Article Open Access

Epidermal growth factor receptor kinase substrate 8 promotes the metastasis of cervical cancer via the epithelial-mesenchymal transition

Qian Li, Wei Bao, Qiong Fan, Wen‑Jing Shi, Zhu‑Nan Li, Ying Xu, Dan Wu
Pages: 3220-3228
Published online on: 18 August 2016

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Article

Curcumin attenuates cyclosporine A‑induced renal fibrosis by inhibiting hypermethylation of the klotho promoter

Ying Hu, Lijun Mou, Fuye Yang, Haiyan Tu, Wanbing Lin
Pages: 3229-3236
Published online on: 08 August 2016

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Article

Dose response of dexmedetomidine‑induced resistance to hypoxia in mice

Wanying Pan, Xiaoxiao Hua, Yueting Wang, Ruixian Guo, Jingfu Chen, Liqiu Mo
Pages: 3237-3242
Published online on: 04 August 2016

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Article

Traditional Chinese medicine: Pivotal role of the spleen in the metabolism of aristolochic acid I in rats is dependent on oatp2a1

Ting Xiang, Zhangbin Yang, Baoguo Sun, Haoxuan Luo, Shijun Zhang, Bin Ren, Xiaoling Chen, Xin Zhou, Zexiong Chen
Pages: 3243-3250
Published online on: 09 August 2016

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Article

Molecular genetic analysis and phenotypic characteristics of a consanguineous family with glycogen storage disease type Ia

Yili Lu, Liyin Wang, Jun Li, Beibei Wu, Huiping Wu, Yue Luo, Zi‑Bing Jin, Xiaoou Shan
Pages: 3251-3254
Published online on: 09 August 2016

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Article

Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells

Min Ju Ryu, Ha Sook Chung
Pages: 3255-3260
Published online on: 11 August 2016

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Article

HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9

Shi‑Wei Chen, Qing Zhang, Zhi‑Feng Xu, Hai‑Ping Wang, Yi Shi, Feng Xu, Wen‑Jian Zhang, Ping Wang, Yong Li
Pages: 3261-3268
Published online on: 19 August 2016

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Article

Characterization of multidrug‑resistant osteosarcoma sublines and the molecular mechanisms of resistance

Jian‑Zeng Yang, Shu‑Rong Ma, Xiao‑Li Rong, Mei‑Ju Zhu, Qiu‑Ye Ji, Ling‑Jie Meng, Yi‑Yao Gao, Yu‑Dan Yang, Yan Wang
Pages: 3269-3276
Published online on: 04 August 2016

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Article

Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model

Weiwei Yang, Liping She, Kun Yu, Shan Yan, Xuefeng Zhang, Xiaoyi Tian, Shuren Ma, Xiwen Zhang
Pages: 3277-3284
Published online on: 18 August 2016

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Article

Let‑7 miRNAs sensitize breast cancer stem cells to radiation‑induced repression through inhibition of the cyclin D1/Akt1/Wnt1 signaling pathway

Huifang Sun, Changmao Ding, Huiyu Zhang, Jianbo Gao
Pages: 3285-3292
Published online on: 19 August 2016

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Article

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

Yi Wang, Li‑Ming Liu, Li Wei, Wei‑Wei Ye, Xiang‑Ying Meng, Feng Chen, Qian Xiao, Jian‑Yang Chen, Yong Zhou
Pages: 3293-3300
Published online on: 18 August 2016

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Article

Sphingomyelin synthase 2 affects CD14‑associated induction of NF‑κB by lipopolysaccharides in acute lung injury in mice

Shidong Hu, Yi Ding, Jie Gong, Nianlong Yan
Pages: 3301-3306
Published online on: 09 August 2016

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Article

A novel TBX20 loss‑of‑function mutation contributes to adult‑onset dilated cardiomyopathy or congenital atrial septal defect

Yi‑Meng Zhou, Xiao‑Yong Dai, Ri‑Tai Huang, Song Xue, Ying‑Jia Xu, Xing‑Biao Qiu, Yi‑Qing Yang
Pages: 3307-3314
Published online on: 09 August 2016

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Article

Correlation between low tapasin expression and impaired CD8+ T‑cell function in patients with chronic hepatitis B

Yuyan Tang, Jieling Wang, Yi Zhang, Meng Zhuo, Linlin Song, Zhenghao Tang, Guoqing Zang, Xiaohua Chen, Yongsheng Yu
Pages: 3315-3322
Published online on: 09 August 2016

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Article

Inflammation has a role in urethane‑induced lung cancer in C57BL/6J mice

Cai Xu, Lingyu Zhou, Lei Lu, Ting Chen, Siyu Wei, Xiaojing Lin, Xuemei Lian
Pages: 3323-3328
Published online on: 19 August 2016

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Article

TRIF is a regulator of TLR2-induced foam cell formation

Bin Huang, Dae‑Weon Park, Suk‑Hwan Baek
Pages: 3329-3335
Published online on: 19 August 2016

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Article

Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration

Yong Huan Song, Yu Ting Zhu, Jian Ding, Fei Ya Zhou, Ji Xin Xue, Jin Hee Jung, Zhi Jie Li, Wei Yang Gao
Pages: 3336-3342
Published online on: 19 August 2016

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Article

miR‑205 suppresses cell proliferation, invasion, and metastasis via regulation of the PTEN/AKT pathway in renal cell carcinoma

Huiqiang Wang, Bin Chen, Bo Duan, Jiaxin Zheng, Xinyi Wu
Pages: 3343-3349
Published online on: 04 August 2016

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Article

Identification of microRNA profiles associated with refractory primary biliary cirrhosis

Teppei Sakamoto, Asahiro Morishita, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Hirohiro Yoneyama, Hisakazu Iwama, Takashi Himoto, Tsutomu Masaki
Pages: 3350-3356
Published online on: 09 August 2016

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Article

PRDM16 is associated with evasion of apoptosis by prostatic cancer cells according to RNA interference screening

Shaoxing Zhu, Yipeng Xu, Mei Song, Guiping Chen, Hua Wang, Yang Zhao, Zongping Wang, Fangyin Li
Pages: 3357-3361
Published online on: 08 August 2016

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Article

Distal hereditary motor neuropathy type 7B with Dynactin 1 mutation

Sun Hee Hwang, Eun Ja Kim, Young Bin Hong, Jaesoon Joo, Sung Min Kim, Soo Hyun Nam, Hyun Dae Hong, Seung Hyun Kim, Kiwook Oh, Jeong‑Geun Lim, Jeong Hee Cho, Ki Wha Chung, Byung‑Ok Choi
Pages: 3362-3368
Published online on: 22 August 2016

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Article

S1PR1 mediates anti‑apoptotic/pro‑proliferative processes in human acute myeloid leukemia cells

Xiao‑Qian Xu, Chong‑Mei Huang, Yi‑Fan Zhang, Li Chen, Hui Cheng, Jian‑Min Wang
Pages: 3369-3375
Published online on: 12 August 2016

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Article

The protective role of p72 in doxorubicin‑induced cardiomyocytes injury in vitro

Bin Lin, Feng Wang, Jiaxiang Wang, Chengyang Xu, Hui Zhao, Zhaoyun Cheng, Deguang Feng
Pages: 3376-3380
Published online on: 08 August 2016

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Article

Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose‑induced renal mesangial cells through cell cycle regulation and induction of apoptosis

Shouzhu Xu, Yanying Lv, Jing Zhao, Junping Wang, Xing Zhao, Siwang Wang
Pages: 3381-3388
Published online on: 12 August 2016

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Article

Lycorine protects cartilage through suppressing the expression of matrix metalloprotenases in rat chondrocytes and in a mouse osteoarthritis model

Shuai Chen, Xiang‑Qian Fang, Jian‑Feng Zhang, Yan Ma, Xiao‑Zhen Tang, Zhi‑Jie Zhou, Ji‑Ying Wang, An Qin, Shun‑Wu Fan
Pages: 3389-3396
Published online on: 08 August 2016

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Article

Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities

Jun Peng, Xingfeng Ren, Tianbiao Lan, Yan Chen, Ziyun Shao, Cheng Yang
Pages: 3397-3402
Published online on: 19 August 2016

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Article

Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways

Li‑Yan Wang, Zhi‑Jun Tang, Yu‑Zeng Han
Pages: 3403-3412
Published online on: 04 August 2016

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Article

Dexmedetomidine pretreatment attenuates propofol‑induced neurotoxicity in neuronal cultures from the rat hippocampus

Yi Wei, Junhua Hu, Yubing Liang, Yuling Zhong, Dan He, Yi Qin, Li Li, Jing Chen, Qiang Xiao, Yubo Xie
Pages: 3413-3420
Published online on: 12 August 2016

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Article

miR‑483‑5p promotes growth, invasion and self‑renewal of gastric cancer stem cells by Wnt/β‑catenin signaling

Kai Wu, Longan Ma, Jinxiang Zhu
Pages: 3421-3428
Published online on: 08 August 2016

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Article

Collagen regulates transforming growth factor-β receptors of HL-1 cardiomyocytes through activation of stretch and integrin signaling

Yen‑Yu Lu, Yung‑Kuo Lin, Yu‑Hsun Kao, Cheng‑Chih Chung, Yung‑Hsin Yeh, Shih‑Ann Chen, Yi‑Jen Chen
Pages: 3429-3436
Published online on: 18 August 2016

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Article

Knockdown of TACC3 inhibits trophoblast cell migration and invasion through the PI3K/Akt signaling pathway

Xiaojun Zhu, Qianqian Cao, Xia Li, Zhengping Wang
Pages: 3437-3442
Published online on: 19 August 2016

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Article

Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women

Ayesha Mazhar, Farrukh Jamil, Qamar Bashir, Munawar Saleem Ahmad, Misbah Masood, Imrana Tanvir, Naeem Rashid, Abdul Waheed, Muhammad Naveed Afzal, Muhammad Akram Tariq
Pages: 3443-3451
Published online on: 18 August 2016

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Article

Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway

Hongbing Gu, Runbi Ji, Xu Zhang, Mei Wang, Wei Zhu, Hui Qian, Yongchang Chen, Pengcheng Jiang, Wenrong Xu
Pages: 3452-3458
Published online on: 11 August 2016

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Article

Plasma heme oxygenase-1 is decreased in peripheral artery disease patients

Salvatore Santo Signorelli, Guido Li Volsi, Valerio Fiore, Marco Mangiafico, Ignazio Barbagallo, Rosalba Parenti, Manfredi Rizzo, Giovanni Li Volti
Pages: 3459-3463
Published online on: 19 August 2016

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Article

Inhibitory effects of B‑cell translocation gene 2 on skin cancer cells via the Wnt/β‑catenin signaling pathway

Shou‑Song Gao, Xiao‑Hong Yang, Meng Wang
Pages: 3464-3468
Published online on: 08 August 2016

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Article

Decitabine enhances bortezomib treatment in RPMI 8226 multiple myeloma cells

Yang Cao, Guo‑Qiang Qiu, Hao‑Qing Wu, Zhi‑Lin Wang, Yan Lin, Wei Wu, Xiao‑Bao Xie, Wei‑Ying Gu
Pages: 3469-3475
Published online on: 19 August 2016

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Article

Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling

Xuan Yin, Xiong‑Wei Yu, Pan Zhu, Yuan‑Ming Zhang, Xiao‑Hong Zhang, Feng Wang, Jin‑Jie Zhang, Wang Yan, Yang Xi, Jian‑Bo Wan, Jing‑Xuan Kang, Zu‑Quan Zou, Shi‑Zhong Bu
Pages: 3476-3484
Published online on: 18 August 2016

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Article

Expression of early and late cellular damage markers by ARPE-19 cells following prolonged treatment with UV-A radiation

Giuseppe Tringali, Beatrice Sampaolese, Maria Elisabetta Clementi
Pages: 3485-3489
Published online on: 19 August 2016

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Article

C‑reactive protein/oxidized low density lipoprotein/β2‑glycoprotein i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen‑activated protein kinase and nuclear factor‑κB signaling pathways

Jie Wang, Mei‑Jun Feng, Rui Zhang, De‑Min Yu, Sai‑Jun Zhou, Rui Chen, Pei Yu
Pages: 3490-3498
Published online on: 11 August 2016

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Article Open Access

Differential activation of c‑Fos in the paraventricular nuclei of the hypothalamus and thalamus following myocardial infarction in rats

Hyun‑Jin Tae, Seung Min Park, Jeong Hwi Cho, In Hye Kim, Ji Hyeon Ahn, Joon Ha Park, Moo‑Ho Won, Bai Hui Chen, Bich‑Na Shin, Myoung Cheol Shin, Choong Hyun Lee, Seongkweon Hong, Jae‑Chul Lee, Jun Hwi Cho
Pages: 3503-3508
Published online on: 07 September 2016

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Article Open Access

Histone deacetylase enzyme silencing using shRNAs enhances radiosensitivity of SW579 thyroid cancer cells

Ye Wang, Tao Jin, Xueming Dai, Dongwang Yan, Zhihai Peng
Pages: 3509-3516
Published online on: 05 September 2016

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Notch 2 signaling contributes to cell growth, anti-apoptosis and metastasis in laryngeal squamous cell carcinoma

You Zou, Fang Fang, Yong‑Jun Ding, Meng‑Yuan Dai, Xing Yi, Chen Chen, Ze‑Zhang Tao, Shi‑Ming Chen
Pages: 3517-3524
Published online on: 29 August 2016

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Severity of pancreatitis‑associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin

Wenhong Deng, Ablikim Abliz, Sheng Xu, Rongze Sun, Wenyi Guo, Qiao Shi, Jia Yu, Weixing Wang
Pages: 3525-3534
Published online on: 26 August 2016

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Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment

Longwei Hu, Jing Han, Xi Yang, Yang Wang, Hongya Pan, Liqun Xu
Pages: 3535-3542
Published online on: 24 August 2016

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Article Open Access

ZFAT gene variant association with multiple sclerosis in the Arabian Gulf population: A genetic basis for gender-associated susceptibility

Sonia Bourguiba‑Hachemi, Tebah K. Ashkanani, Fatema J. Kadhem, Wassim Y. Almawi, Raed Alroughani, M. Dahmani Fathallah
Pages: 3543-3550
Published online on: 30 August 2016

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Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer

Wei Zhang, Hua Xiong, Yanmei Zou, Sanpeng Xu, Lanping Quan, Xianglin Yuan, Ningzhi Xu, Yihua Wang
Pages: 3551-3558
Published online on: 05 September 2016

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Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-κB signaling pathway

Yu‑Lun Wang, Gen‑Yi Sun, Ying Zhang, Jia‑Jun He, Shen Zheng, Jing‑Na Lin
Pages: 3559-3564
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The differentiation potential of gingival mesenchymal stem cells induced by apical tooth germ cell‑conditioned medium

Yan Chen, Hongwei Liu
Pages: 3565-3572
Published online on: 06 September 2016

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Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitro Corrigendum in /10.3892/mmr.2020.11278

Fuben Xu, Huayu Wu, Kun Zhang, Peizhen Lv, Li Zheng, Jinmin Zhao
Pages: 3573-3580
Published online on: 06 September 2016

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Protective effect of active perfusion in porcine models of acute myocardial ischemia

Zanxiang Feng, Zhifu Mao, Shengjun Dong, Baohui Liu
Pages: 3581-3587
Published online on: 24 August 2016

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Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction

Yang Mu, Wen‑Jie Yan, Tai‑Lang Yin, Jing Yang
Pages: 3588-3594
Published online on: 05 September 2016

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Article Open Access

Impact of siRNA targeting of β-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damage

Xiaoying Zhang, Cuicui Zhu, Qiong Luo, Jv Dong, Lv Liu, Min Li, Hongtao Zhu, Xiangping Ma, Jun Wang
Pages: 3595-3601
Published online on: 24 August 2016

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Upregulation of retinoic acid receptor-β reverses drug resistance in cholangiocarcinoma cells by enhancing susceptibility to apoptosis

Hong‑Yue Ren, Bo Chen, Gui‑Li Huang, Yu Liu, Dong‑Yan Shen
Pages: 3602-3608
Published online on: 02 September 2016

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Development of a model based on biochemical, real‑time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B

Shi‑Hao Xu, Qiao Li, Yuan‑Ping Hu, Li Ying
Pages: 3609-3619
Published online on: 26 August 2016

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Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways

Wei Shang, Ling‑Jie Zhao, Xiao‑Lei Dong, Zhi‑Ming Zhao, Jing Li, Bei‑Bei Zhang, Hui Cai
Pages: 3620-3626
Published online on: 25 August 2016

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Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cells

Wei‑Wei Zhang, Shu‑Hui Zhan, Chang‑Xin Geng, Xin Sun, Mert Erkan, Jörg Kleeff, Xiang‑Jun Xie
Pages: 3627-3633
Published online on: 26 August 2016

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In vitro antitumor activity of the ethyl acetate extract of Potentilla chinensis in osteosarcoma cancer cells Retraction in /10.3892/mmr.2021.12129

Guang Wan, Jin‑Gang Tao, Guo‑Dong Wang, Shen‑Peng Liu, Hong‑Xing Zhao, Qiu‑Dong Liang
Pages: 3634-3640
Published online on: 26 August 2016

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Case Report Open Access

A novel KMT2D mutation resulting in Kabuki syndrome: A case report

Jun Lu, Guiling Mo, Yaojun Ling, Lijuan Ji
Pages: 3641-3645
Published online on: 26 August 2016

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Resveratrol pretreatment attenuates injury and promotes proliferation of neural stem cells following oxygen-glucose deprivation/reoxygenation by upregulating the expression of Nrf2, HO-1 and NQO1 in vitro

Changbo Shen, Wei Cheng, Pingping Yu, Li Wang, Lulin Zhou, Li Zeng, Qin Yang
Pages: 3646-3654
Published online on: 24 August 2016

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Article Open Access

Cytoplasmic translocation of high-mobility group box-1 protein is induced by diabetes and high glucose in retinal pericytes

Junghyun Kim, Chan‑Sik Kim, Eunjin Sohn, Jin Sook Kim
Pages: 3655-3661
Published online on: 02 September 2016

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Liraglutide attenuates the osteoblastic differentiation of MC3T3‑E1 cells by modulating AMPK/mTOR signaling

Xiong‑Ke Hu, Xin‑Hua Yin, Hong‑Qi Zhang, Chao‑Feng Guo, Ming‑Xing Tang
Pages: 3662-3668
Published online on: 06 September 2016

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Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro

Xiao‑Ya Liu, Rui‑Xia Liu, Fei Hou, Li‑Jian Cui, Chun-Yun Li, Cheng Chi, Entong Yi, Yan Wen, Cheng‑Hong Yin
Pages: 3669-3675
Published online on: 25 August 2016

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Expressing human SHOX in Shox2SHOX KI/KI mice leads to congenital osteoarthritis‑like disease of the temporomandibular joint in postnatal mice

Wenna Liang, Xihai Li, Houhuang Chen, Xiang Shao, Xuejuan Lin, Jianying Shen, Shanshan Ding, Jie Kang, Candong Li
Pages: 3676-3682
Published online on: 05 September 2016

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Resveratrol attenuates acute kidney injury by inhibiting death receptor‑mediated apoptotic pathways in a cisplatin‑induced rat model

Qiufa Hao, Xiaoyan Xiao, Junhui Zhen, Jinbo Feng, Chun Song, Bei Jiang, Zhao Hu
Pages: 3683-3689
Published online on: 05 September 2016

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Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury

Yang Wang, Chunhu Zhang, Weijun Peng, Zian Xia, Pingping Gan, Wei Huang, Yafei Shi, Rong Fan
Pages: 3690-3696
Published online on: 06 September 2016

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Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs

Changhwan Ahn, Da‑Hye Shin, Dongoh Lee, Su‑Myung Kang, Ju‑Hyung Seok, Hee Young Kang, Eui‑Bae Jeung
Pages: 3697-3703
Published online on: 06 September 2016

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Antiviral activities of atractylon from Atractylodis Rhizoma

Yang Cheng, Jing‑Yin Mai, Tian‑Lu Hou, Jian Ping, Jian‑Jie Chen
Pages: 3704-3710
Published online on: 05 September 2016

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Article

Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress

Ying Liang, Jian Wang, Haiqing Gao, Quanzhen Wang, Jun Zhang, Jie Qiu
Pages: 3711-3718
Published online on: 01 September 2016

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Article

Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival

Yong Chan Bae, Chi Won Choi, Kyeong Wook Nam, Ji Sun Song, Jae Woo Lee
Pages: 3719-3724
Published online on: 26 August 2016

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Article

shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathway

Yue Shi, Duo Zuo, Xia Wang, Meng Han, Yan Wu
Pages: 3725-3730
Published online on: 06 September 2016

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Article

Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3

Yaoguang Wang, Xiaokai Yang, Weide Ma, Jinxin Li, Qingyuan Zhang, Shuqi Xia, Hai Wang, Chenghui Zhang, Xiaomin Xu, Jiayong Zheng
Pages: 3731-3734
Published online on: 05 September 2016

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Article

Haptoglobin protein and mRNA expression in psoriasis and its clinical significance

Fu-Jun Tian, Ying-Ying Zhang, Li-Qian Liu, Ying Xiong, Zong-Shan Wang, Shou-Zhong Wang
Pages: 3735-3742
Published online on: 25 August 2016

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Article

Heparin inhibits the inflammation and proliferation of human rheumatoid arthritis fibroblast‑like synoviocytes through the NF‑κB pathway

Li Qi, Xiaoli Zhang, Xiaofei Wang
Pages: 3743-3748
Published online on: 06 September 2016

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Article

Anti‑inflammatory effects of Ciwujianoside C3, extracted from the leaves of Acanthopanax henryi (Oliv.) Harms, on LPS‑stimulated RAW 264.7 cells

Da‑Hye Kang, Ok‑Hwa Kang, Zhi Li, Su‑Hyun Mun, Yun‑Soo Seo, Ryong Kong, Zhou Tian, Xiangqian Liu, Dong‑Yeul Kwon
Pages: 3749-3758
Published online on: 05 September 2016

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Article

Expression of far upstream element binding protein 1 in B‑cell non‑Hodgkin lymphoma is correlated with tumor growth and cell‑adhesion mediated drug resistance

Yuejiao Huang, Xiaohong Xu, Lili Ji, Yuchan Wang, Shitao Wang, Jie Tang, Xianting Huang, Xiaojing Yang, Yunhua He, Song He, Chun Cheng
Pages: 3759-3768
Published online on: 06 September 2016

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Article

Osteoprotective effects of osthole in a mouse model of 5/6 nephrectomy through inhibiting osteoclast formation

Xiaofeng Li, Chunchun Xue, Libo Wang, Dezhi Tang, Jian Huang, Yongjian Zhao, Yan Chen, Dongfeng Zhao, Qi Shi, Yongjun Wang, Bing Shu
Pages: 3769-3776
Published online on: 29 August 2016

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Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells

Jun Hee Lee, Ho Kyung Jung, Yong‑Seok Han, Yeo Min Yoon, Chul Won Yun, Hwa Yeon Sun, Hyun Woo Cho, Sang Hun Lee
Pages: 3777-3784
Published online on: 05 September 2016

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Article

Bioinformatics analysis of gene expression profiles of dermatomyositis

Liang‑Yuan Chen, Zhao‑Lei Cui, Fan‑Cui Hua, Weng‑Jing Yang, Ye Bai, Feng‑Hua Lan
Pages: 3785-3790
Published online on: 02 September 2016

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Article

Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumors

Lucas Tadeu Bidinotto, Carlos A R Véo, Edgar Aleman Loaiza, Alessandra Paulino Santos De França, Adriana Tarla Lorenzi, Luciana Albina Reis Rosa, Cristina Mendes De Oliveira, José Eduardo Levi, Cristovam Scapulatempo‑Neto, Adhemar Longatto‑Filho, Rui Manuel Reis
Pages: 3791-3797
Published online on: 26 August 2016

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Article

Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway

Hong‑Fei Xu, Xiao‑Yun Fang, Shao‑Hua Zhu, Xue‑Hua Xu, Zhi‑Xiang Zhang, Zu‑Feng Wang, Zi‑Qin Zhao, Yu‑Jie Ding, Lu‑Yang Tao
Pages: 3798-3804
Published online on: 06 September 2016

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Article

Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis

Zhikui Gao, Ran Liu, Juan Liao, Miao Yang, Enchun Pan, Lihong Yin, Yuepu Pu
Pages: 3805-3813
Published online on: 30 August 2016

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Article

Proteomic analysis of selective cytotoxic anticancer properties of flavonoids isolated from Citrus platymamma on A549 human lung cancer cells

Arulkumar Nagappan, Venu Venkatarame Gowda Saralamma, Gyeong Eun Hong, Ho Jeong Lee, Sung Chul Shin, Eun Hee Kim, Won Sup Lee, Gon Sup Kim
Pages: 3814-3822
Published online on: 24 August 2016

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Article

Identification of differentially expressed genes affecting hair and cashmere growth in the Laiwu black goat by microarray

Jinshan Zhao, Hegang Li, Kaidong Liu, Baoxun Zhang, Peipei Li, Jianning He, Ming Cheng, Wei De, Jifeng Liu, Yaofeng Zhao, Lihua Yang, Nan Liu
Pages: 3823-3831
Published online on: 06 September 2016

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Article

Effects of tongxinluo on angiogenesis in the carotid adventitia of hyperlipidemic rabbits

Jianhua Zhou, Bingfeng Cao, Weiping Ju, Sen Liu, Jianguang Song, Lixia Liu
Pages: 3832-3840
Published online on: 25 August 2016

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Article

Matrine induces the hepatic differentiation of WB-F344 rat hepatic progenitor cells and inhibits Jagged 1/HES1 signaling

Zhiyun Yang, Li Wang, Xianbo Wang
Pages: 3841-3847
Published online on: 24 August 2016

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Article

Nkx2.5/CARP signaling pathway contributes to the regulation of ion channel remodeling induced by rapid pacing in rat atrial myocytes

Wei Wang, Yun Zhu, Jianguang Yi, Wei Cheng
Pages: 3848-3854
Published online on: 06 September 2016

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Article

p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells

Hai‑Yan Wang, Hai‑Zhong Yu, Sheng‑Mou Huang, Yu‑Lan Zheng
Pages: 3855-3861
Published online on: 31 August 2016

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Article

Comparison of bone marrow tissue- and adipose tissue-derived mesenchymal stem cells in the treatment of sepsis in a murine model of lipopolysaccharide-induced sepsis

Hao Ou, Shangping Zhao, Yue Peng, Xuefei Xiao, Qianlu Wang, Huaizeng Liu, Xianzhong Xiao, Mingshi Yang
Pages: 3862-3870
Published online on: 30 August 2016

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Article

Effects of hydrogen sulfide on the expression of alkaline phosphatase, osteocalcin and collagen type I in human periodontal ligament cells induced by tension force stimulation

Jing Qin, Yongmei Hua
Pages: 3871-3877
Published online on: 26 August 2016

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Article

S100B suppresses the differentiation of C3H/10T1/2 murine embryonic mesenchymal cells into osteoblasts

Dong Li, Kaihua Li, Gang Chen, Jianlong Xia, Ting Yang, Ping Cai, Chen Yao, Yongjiang Yang, Shichang Yan, Rihua Zhang, Hui Chen
Pages: 3878-3886
Published online on: 01 September 2016

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Article

Co‑culture of fibroblast‑like synoviocytes with umbilical cord‑mesenchymal stem cells inhibits expression of pro‑inflammatory proteins, induces apoptosis and promotes chondrogenesis

Jingqi Zeng, Fan Wang, Minzhi Mao
Pages: 3887-3893
Published online on: 06 September 2016

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Article

Effect of high-fat diet-induced obesity on the Akt/FoxO/Smad signaling pathway and the follicular development of the mouse ovary

Yanqing Wu, Zhenghong Zhang, Xinghui Liao, Lingbin Qi, Yiping Liu, Zhengchao Wang
Pages: 3894-3900
Published online on: 25 August 2016

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Article

Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway

Ou Lv, Fenggang Zhou, Yongri Zheng, Qingsong Li, Jianjiao Wang, Yulan Zhu
Pages: 3901-3907
Published online on: 05 September 2016

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Article

Regulation of the pacemaker activities in cultured interstitial cells of Cajal by Citrus unshiu peel extracts

Ji Hwan Shim, Soo Jin Lee, Huijin Gim, Hyun Jung Kim, Taewon Han, Jae Goo Kim, Eun Yeong Lim, Yun Tai Kim, Byung Joo Kim
Pages: 3908-3916
Published online on: 30 August 2016

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Article

Inhibiting the role of Skp2 suppresses cell proliferation and tumorigenesis of human gastric cancer cells via the upregulation of p27kip1

Yanguang Wen, Kuansong Wang, Kaiyan Yang
Pages: 3917-3924
Published online on: 25 August 2016

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Article

Activation of mTOR signaling leads to orthopedic surgery-induced cognitive decline in mice through β-amyloid accumulation and tau phosphorylation

Wenzhen Shen, Keliang Lu, Jiawan Wang, Anshi Wu, Yun Yue
Pages: 3925-3934
Published online on: 01 September 2016

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Article

Myeloid-derived suppressor cells are elevated in patients with psoriasis and produce various molecules

Dan Ilkovitch, Laura K. Ferris
Pages: 3935-3940
Published online on: 26 August 2016

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Article

Iodine regulates G2/M progression induced by CCL21/CCR7 interaction in primary cultures of papillary thyroid cancer cells with RET/PTC expression

You‑Yuan Zhang, Ze‑Bing Liu, Xuan‑Guang Ye, Wei‑Min Ren
Pages: 3941-3946
Published online on: 29 August 2016

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Article

Structure and antioxidant activity of a novel polysaccharide derived from Amanita caesarea

Yuanxiu Zhu, Xiang Ding, Mei Wang, Yiling Hou, Wanru Hou, Changwu Yue
Pages: 3947-3954
Published online on: 30 August 2016

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Article

SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cells

Eun Kyoung Choi, Seung‑Mi Kim, Seung‑Woo Hong, Jai‑Hee Moon, Jae‑Sik Shin, Jeong Hee Kim, Ih‑Yeon Hwang, Soo‑A Jung, Dae‑Hee Lee, Eun Young Lee, Seul Lee, Hyunwoo Kim, Daejin Kim, Yeong Seok Kim, Youn Kyung Choi, Hyo In Kim, Hyeong Sim Choi, Sung‑Gook Cho, Jeong Eun Kim, Kyu Pyo Kim, Yong Sang Hong, Won Keun Lee, Jung Shin Lee, Tae Won Kim, Seong‑Gyu Ko, Dong‑Hoon Jin
Pages: 3955-3960
Published online on: 06 September 2016

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Article

Sp1 downregulates proinflammatory cytokine‑induced catabolic gene expression in nucleus pulposus cells

Kang Xu, Xiaofei Wang, Qianshi Zhang, Anjing Liang, Haipeng Zhu, Dongsheng Huang, Chunhai Li, Wei Ye
Pages: 3961-3968
Published online on: 06 September 2016

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Article

Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes

Magdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska
Pages: 3969-3977
Published online on: 05 September 2016

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Article

Role of histone modification in 12‑lipoxygenase‑associated p21 gene regulation

Yingchun Cui, Nian Liu, Fuzhe Ma, Weixia Sun, Hao Wu, Zhonggao Xu, Hang Yuan
Pages: 3978-3984
Published online on: 06 September 2016

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Article

Berberine induces pacemaker potential inhibition via cGMP-dependent ATP-sensitive K+ channels by stimulating mu/delta opioid receptors in cultured interstitial cells of Cajal from mouse small intestine

Hyun Jung Kim, Hyungwoo Kim, Myeong Ho Jung, Young Kyu Kwon, Byung Joo Kim
Pages: 3985-3991
Published online on: 01 September 2016

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Article

Effects of endomorphin-1 postconditioning on myocardial ischemia/reperfusion injury and myocardial cell apoptosis in a rat model

Wei‑Ping Zhang, Qiao‑Feng Zong, Qin Gao, Ying Yu, Xiao‑Yu Gu, Ya Wang, Zheng‑Hong Li, Min Ge
Pages: 3992-3998
Published online on: 31 August 2016

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Article

Inhibiting autophagy promotes endoplasmic reticulum stress and the ROS‑induced nod‑like receptor 3‑dependent proinflammatory response in HepG2 cells

Jia‑Jing Yin, Guangying Xie, Ning Zhang, Yanbo Li
Pages: 3999-4007
Published online on: 05 September 2016

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Retraction Open Access

[Retracted] Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth

Chun‑Tao Liu, Ying Xin, Chun‑Yan Tong, Bing Li, Hong‑Li Bao, Cai‑Yun Zhang, Xue‑Hui Wang
Pages: 4008-4008
Published online on: 07 September 2016

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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Retraction Open Access

[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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Correction Open Access

[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Review

RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Article Open Access

Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Article Open Access

Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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Retraction Open Access

[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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Review Open Access

R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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Retraction Open Access

[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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