Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway

  • Authors:
    • Ou Lv
    • Fenggang Zhou
    • Yongri Zheng
    • Qingsong Li
    • Jianjiao Wang
    • Yulan Zhu
  • View Affiliations

  • Published online on: September 5, 2016     https://doi.org/10.3892/mmr.2016.5709
  • Pages: 3901-3907
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Abstract

Subarachnoid hemorrhage (SAH) is a severe neurological disease, which is associated with a significant number of cases of premature mortality and disability worldwide. Mild hypothermia (MH) has been proposed as a potential therapeutic strategy to reduce neuronal injury following SAH. The present study aimed to investigate the mechanisms of MH’s protective role in the process of SAH. The present study demonstrated that MH was able to protect against early brain injury in a rat model of SAH. Treating SAH rats with MH reduced the release of reactive oxygen species and prevented activation of apoptotic cascades. Furthermore, the protective effects of MH were shown to be mediated by enhanced activity of the tropomyosin receptor kinase B/extracellular signal‑regulated kinases/cAMP response element binding protein (TrkB/ERK/CREB) pathway. Inhibition of TrkB/ERK/CREB activity using a small molecule inhibitor largely abolished the beneficial effects of MH in SAH rats. These results outline an endogenous mechanism underlying the neuroprotective effects of MH in SAH.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lv O, Zhou F, Zheng Y, Li Q, Wang J and Zhu Y: Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway. Mol Med Rep 14: 3901-3907, 2016.
APA
Lv, O., Zhou, F., Zheng, Y., Li, Q., Wang, J., & Zhu, Y. (2016). Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway. Molecular Medicine Reports, 14, 3901-3907. https://doi.org/10.3892/mmr.2016.5709
MLA
Lv, O., Zhou, F., Zheng, Y., Li, Q., Wang, J., Zhu, Y."Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway". Molecular Medicine Reports 14.4 (2016): 3901-3907.
Chicago
Lv, O., Zhou, F., Zheng, Y., Li, Q., Wang, J., Zhu, Y."Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway". Molecular Medicine Reports 14, no. 4 (2016): 3901-3907. https://doi.org/10.3892/mmr.2016.5709