Open Access

miRNAs and their role in the correlation between schizophrenia and cancer (Review)

  • Authors:
    • E. Rizos
    • N. Siafakas
    • E. Skourti
    • C. Papageorgiou
    • J. Tsoporis
    • T. H. Parker
    • D. I. Christodoulou
    • D. A. Spandidos
    • E. Katsantoni
    • V. Zoumpourlis
  • View Affiliations

  • Published online on: October 14, 2016     https://doi.org/10.3892/mmr.2016.5853
  • Pages: 4942-4946
  • Copyright: © Rizos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate. Recent evidence has indicated that microRNAs (miRNAs or miRs), a large group of small non‑coding oligonoucleotides, may play a significant role in the development of Ca and major psychiatric disorders, such as SZ, bipolar disorder, autism spectrum disorders, suicidality and depression, through their interference with the expression of multiple genes. For instance, the possible role of let‑7, miR‑98 and miR‑183 as biomarkers for Ca and SZ was investigated in our previous research studies. Therefore, further investigations on the expression profiles of these regulatory, small RNA molecules and the molecular pathways through which they exert their control may provide a plausible explanation as to whether there is a correlation between psychiatric disorders and low risk of developing Ca.
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December-2016
Volume 14 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Rizos E, Siafakas N, Skourti E, Papageorgiou C, Tsoporis J, Parker TH, Christodoulou DI, Spandidos DA, Katsantoni E, Zoumpourlis V, Zoumpourlis V, et al: miRNAs and their role in the correlation between schizophrenia and cancer (Review). Mol Med Rep 14: 4942-4946, 2016
APA
Rizos, E., Siafakas, N., Skourti, E., Papageorgiou, C., Tsoporis, J., Parker, T.H. ... Zoumpourlis, V. (2016). miRNAs and their role in the correlation between schizophrenia and cancer (Review). Molecular Medicine Reports, 14, 4942-4946. https://doi.org/10.3892/mmr.2016.5853
MLA
Rizos, E., Siafakas, N., Skourti, E., Papageorgiou, C., Tsoporis, J., Parker, T. H., Christodoulou, D. I., Spandidos, D. A., Katsantoni, E., Zoumpourlis, V."miRNAs and their role in the correlation between schizophrenia and cancer (Review)". Molecular Medicine Reports 14.6 (2016): 4942-4946.
Chicago
Rizos, E., Siafakas, N., Skourti, E., Papageorgiou, C., Tsoporis, J., Parker, T. H., Christodoulou, D. I., Spandidos, D. A., Katsantoni, E., Zoumpourlis, V."miRNAs and their role in the correlation between schizophrenia and cancer (Review)". Molecular Medicine Reports 14, no. 6 (2016): 4942-4946. https://doi.org/10.3892/mmr.2016.5853