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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2016 Volume 14 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Post-translational modifications of FOXO family proteins (Review)

Ziyao Wang, Tinghe Yu, Ping Huang
Pages: 4931-4941
Published online on: 20 October 2016

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Review Open Access

miRNAs and their role in the correlation between schizophrenia and cancer (Review)

E. Rizos, N. Siafakas, E. Skourti, C. Papageorgiou, J. Tsoporis, T. H. Parker, D. I. Christodoulou, D. A. Spandidos, E. Katsantoni, V. Zoumpourlis
Pages: 4942-4946
Published online on: 14 October 2016

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Article Open Access

Rho kinase II interference by small hairpin RNA ameliorates 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine‑induced parkinsonism in mice

Qiong Zhang, Yong‑Fei Zhao, Jian‑Ying Xi, Wen‑Bo Yu, Bao‑Guo Xiao
Pages: 4947-4956
Published online on: 26 October 2016

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Article Open Access

Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo

Na‑Shun Mengke, Bei Hu, Qian‑Peng Han, Yi‑Yu Deng, Ming Fang, Di Xie, Ang Li, Hong‑Ke Zeng
Pages: 4957-4966
Published online on: 25 October 2016

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Article Open Access

Changes in enteroendocrine and immune cells following colitis induction by TNBS in rats

Magdy El‑Salhy, Jan Gunnar Hatlebakk
Pages: 4967-4974
Published online on: 31 October 2016

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Article Open Access

The impact of Wnt signalling and hypoxia on osteogenic and cementogenic differentiation in human periodontal ligament cells

Shuigen Li, Jin Shao, Yinghong Zhou, Thor Friis, Jiangwu Yao, Bin Shi, Yin Xiao
Pages: 4975-4982
Published online on: 31 October 2016

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Article Open Access

Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410

Dong Zhao, Lufang Tong, Lixin Zhang, Hong Li, Yingxin Wan, Tiezhong Zhang
Pages: 4983-4990
Published online on: 01 November 2016

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Article Open Access

Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics

Jun Shao, Wei Fan, Biao Ma, Yiping Wu
Pages: 4991-4998
Published online on: 27 October 2016

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Article Open Access

Identification of HLA‑A*1101‑restricted cytotoxic T lymphocyte epitopes derived from epidermal growth factor pathway substrate number 8

Huifang Lu, Baishan Tang, Yanjie He, Weijun Zhou, Jielei Qiu, Yuhua Li
Pages: 4999-5006
Published online on: 25 October 2016

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Article Open Access

Transcription factor NF‑YA promotes a malignant phenotype by upregulating fatty acid synthase expression

Jing Guo, Ling Min Kong, Ai Fen Peng, Xin Hua Long, Yang Zhou, Yong Shu
Pages: 5007-5014
Published online on: 27 October 2016

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Article Open Access

Aberrant expression of B7‑H4 may contribute to the development of hepatocellular carcinoma

Lingling Yuan, Lijie Dong, Guohua Yu, Wanfeng Fan, Lin Zhang, Peiyuan Wang, Xuemei Hu, Mingdong Zhao
Pages: 5015-5024
Published online on: 25 October 2016

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Article Open Access

miR-129 predicts prognosis and inhibits cell growth in human prostate carcinoma

Song Xu, Xiao‑Ming Yi, Zheng‑Yu Zhang, Jing‑Ping Ge, Wen‑Quan Zhou
Pages: 5025-5032
Published online on: 19 October 2016

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Article Open Access

NFAT5 participates in seawater inhalation‑induced acute lung injury via modulation of NF-κB activity

Congcong Li, Manling Liu, Liyan Bo, Wei Liu, Qingqing Liu, Xiangjun Chen, Dunquan Xu, Zhichao Li, Faguang Jin
Pages: 5033-5040
Published online on: 19 October 2016

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Article Open Access

Identification of potential biomarkers and drugs for papillary thyroid cancer based on gene expression profile analysis

Ting Qu, Yan‑Ping Li, Xiao‑Hong Li, Yan Chen
Pages: 5041-5048
Published online on: 19 October 2016

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Article Open Access

miR‑34a suppresses proliferation and induces apoptosis of human lens epithelial cells by targeting E2F3

Wu Xiang, Haotian Lin, Qilin Wang, Wan Chen, Zhaochuan Liu, Hui Chen, Hui Zhang, Weirong Chen
Pages: 5049-5056
Published online on: 27 October 2016

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Article Open Access

Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration

Sha Li, Bin Zhou, Ben Liu, Yaou Zhou, Huali Zhang, Tong Li, Xiaoxia Zuo
Pages: 5057-5064
Published online on: 31 October 2016

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Article Open Access

Notch1 is associated with the differentiation of human bone marrow‑derived mesenchymal stem cells to cardiomyocytes

Zipu Yu, Yu Zou, Jingya Fan, Chengchen Li, Liang Ma
Pages: 5065-5071
Published online on: 19 October 2016

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Article Open Access

Systemic symptoms in irritable bowel syndrome: An investigative study on the role of enterocyte disintegrity, endotoxemia and inflammation

Ragnhild Undseth, Arnold Berstad, Jørgen Valeur
Pages: 5072-5076
Published online on: 21 October 2016

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Article Open Access

Whole-exome sequencing identification of novel DNAH5 mutations in a young patient with primary ciliary dyskinesia

Gen Kano, Hisashi Tsujii, Kazuhiko Takeuchi, Kaname Nakatani, Makoto Ikejiri, Satoru Ogawa, Hisami Kubo, Mizuho Nagao, Takao Fujisawa
Pages: 5077-5083
Published online on: 21 October 2016

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Article Open Access

Mechanical stretch regulates microRNA expression profile via NF-κB activation in C2C12 myoblasts

Wenxi Hua, Mahui Zhang, Yongkui Wang, Lei Yu, Tingting Zhao, Xiaozhong Qiu, Leyu Wang
Pages: 5084-5092
Published online on: 31 October 2016

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Article Open Access

Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes

Ying Liu, Lei Liu, Tao Yu, He‑Chun Lin, Dandan Chu, Wei Deng, Ming‑Xia Yan, Jing Li, Ming Yao
Pages: 5093-5103
Published online on: 01 November 2016

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Article Open Access

mRNA expression of delta-HER2 and its clinicopathological correlation in HER2-overexpressing breast cancer

Ryuichi Wada, Soroku Yagihashi, Zenya Naito
Pages: 5104-5110
Published online on: 26 October 2016

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Article Open Access

ATP5B and ETFB metabolic markers in children with congenital hydronephrosis

Qi Zhao, Yi Yang, Changlin Wang, Ying Hou, Hui Chen
Pages: 5111-5115
Published online on: 01 November 2016

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Article Open Access

Effects of the IGF-1/PTEN/Akt/FoxO signaling pathway on male reproduction in rats subjected to water immersion and restraint stress

Pan Huang, Zhengrong Zhou, Fangxiong Shi, Genbao Shao, Ran Wang, Jintian Wang, Kangxin Wang, Wei Ding
Pages: 5116-5124
Published online on: 24 October 2016

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Article Open Access

Effects of inactivated Enterococcus faecalis on the proliferation and osteogenic induction of osteoblasts

Zhongchun Tong, Jinglei Ma, Jiali Tan, Lijia Huang, Junqi Ling
Pages: 5125-5133
Published online on: 26 October 2016

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Article Open Access

Chromosome 10q26 deletion syndrome: Two new cases and a review of the literature

Shaobin Lin, Yi Zhou, Qun Fang, Jianzhu Wu, Zhiqiang Zhang, Yuanjun Ji, Yanmin Luo
Pages: 5134-5140
Published online on: 19 October 2016

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Article Open Access

Suppressive effects of Gua Lou Gui Zhi decoction on MCAO-induced NO and PGE2 production are dependent on the MAPK and NF-κB signaling pathways

Haixia Hu, Xiaoqin Zhu, Ruhui Lin, Zuanfang Li, Lidian Chen
Pages: 5141-5147
Published online on: 21 October 2016

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Article Open Access

Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells

Seung‑Hyun Jeong, You‑Jin Jeon, Sun Joo Park
Pages: 5148-5154
Published online on: 21 October 2016

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Article Open Access

Extracts containing CLPs of Bacillus amyloliquefaciens JN68 isolated from chicken intestines exert antimicrobial effects, particularly on methicillin-resistant Staphylococcus aureus and Listeria monocytogenes

Jen‑Ni Chen, Chyou‑Wei Wei, Hsiao‑Chun Liu, Shu‑Ying Chen, Chinshuh Chen, Yu‑Min Juang, Chien‑Chen Lai, Giou‑Teng Yiang
Pages: 5155-5163
Published online on: 27 October 2016

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Article Open Access

Combined antitumor activity of the nitroreductase/CB1954 suicide gene system and γ-rays in HeLa cells in vitro

Geling Teng, Yuanrong Ju, Yepeng Yang, Hu Hua, Jingyu Chi, Xiuan Mu
Pages: 5164-5170
Published online on: 01 November 2016

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Article Open Access

Expression and correlation of NRF2, KEAP1, NQO-1 and HO-1 in advanced squamous cell carcinoma of the larynx and their association with clinicopathologic features

Changjiang Li, Haitao Wu, Shuyi Wang, Jiaxing Zhu
Pages: 5171-5179
Published online on: 01 November 2016

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Article Open Access

Combined application of Rho-ROCKII and GSK-3β inhibitors exerts an improved protective effect on axonal regeneration in rats with spinal cord injury

Ge Zhang, Fei Lei, Qingzhong Zhou, Daxiong Feng, Yongheng Bai
Pages: 5180-5188
Published online on: 01 November 2016

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Article

SLC25A13 cDNA cloning analysis using peripheral blood lymphocytes facilitates the identification of a large deletion mutation: Molecular diagnosis of an infant with neonatal intrahepatic cholestasis caused by citrin deficiency

Han‑Shi Zeng, Wei‑Xia Lin, Shu‑Tao Zhao, Zhan‑Hui Zhang, Heng‑Wen Yang, Feng‑Ping Chen, Yuan‑Zong Song, Zhi‑Nan Yin
Pages: 5189-5194
Published online on: 21 October 2016

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Article

A novel blood-pooling MR contrast agent: Carboxymethyl-diethylaminoethyl dextran magnetite

Akinaga Sonoda, Norihisa Nitta, Keiko Tsuchiya, Ayumi Nitta‑Seko, Shinichi Ohta, Hideji Otani, Kiyoshi Murata
Pages: 5195-5198
Published online on: 21 October 2016

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Article

Knockdown of macrophage inhibitory cytokine-1 in RPMI-8226 human multiple myeloma cells inhibits osteoclastic differentiation through inhibiting the RANKL-Erk1/2 signaling pathway

Mingzhou Yuan, Junmin Chen, Zhiyong Zeng
Pages: 5199-5204
Published online on: 24 October 2016

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Article

PACE4 regulates apoptosis in human pancreatic cancer Panc‑1 cells via the mitochondrial signaling pathway

Xiao‑Feng Tian, Guo‑Min Huang, Hong‑Liang Zang, Hong Cao
Pages: 5205-5210
Published online on: 25 October 2016

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Article

Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity

Xue‑Fang Li, Quan‑Yong Huang, Wen‑Zhong Yang, Hui‑Jie Wang, Can‑Wei Li
Pages: 5211-5216
Published online on: 19 October 2016

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Article

Recombinant human soluble thrombomodulin protects against brain injury in a CVST rat model, via downregulation of the HMGB1-RAGE axis

Jian‑Jun Gu, Jie‑Bin Chen, Jian‑He Zhang, Hao Zhang, Shou‑Sen Wang
Pages: 5217-5222
Published online on: 26 October 2016

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Article

Microfloral diversity in the lower respiratory tracts of neonates with bacterial infectious pneumonia combined with ventilator‑associated pneumonia

Wei Lu, Jia‑Lin Yu, Lu‑Quan Li, Qi Lu, Zheng‑Li Wang, Yun Pan
Pages: 5223-5230
Published online on: 25 October 2016

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Article

Resveratrol induces cell cycle arrest and apoptosis in human eosinophils from asthmatic individuals

Xin Hu, Jing Wang, Yu Xia, Mihereguli Simayi, Syed Ikramullah, Yuanbing He, Shihong Cui, Shuang Li, Qimanguli Wushouer
Pages: 5231-5236
Published online on: 25 October 2016

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Article

Peptide mimics of a carbohydrate‑associated epitope expressed by cancer cells: Identification of vaccine candidates

Liyan Wen, Sha Yang, Ping Zhu, Yingxin Yu, Xiaoyan Qiu, Ning Fu, Yanjun Liu
Pages: 5237-5244
Published online on: 19 October 2016

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Article

Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy

Xiuli Zhang, Dan Liang, Xu Lian, Zhi‑Hong Chi, Xuemei Wang, Yue Zhao, Zhang Ping
Pages: 5245-5252
Published online on: 20 October 2016

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Article

HEB silencing induces anti-proliferative effects on U87MG cells cultured as neurospheres and monolayers

Paulo R. D. V. Godoy, Ana Paula L. Montaldi, Elza T. Sakamoto‑Hojo
Pages: 5253-5260
Published online on: 21 October 2016

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Article

The Hedgehog signaling pathway is associated with poor prognosis in breast cancer patients with the CD44+/CD24‑ phenotype

Haishan Zhao, Hongtao Tang, Qinghuan Xiao, Miao He, Lin Zhao, Yingzi Fu, Huizhe Wu, Zhaojin Yu, Qian Jiang, Yuanyuan Yan, Feng Jin, Minjie Wei
Pages: 5261-5270
Published online on: 19 October 2016

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Article

Glucocorticoid receptor contributes to the altered expression of hepatic cytochrome P450 upon cigarette smoking

Xue Li, Zhongfang Yan, Qi Wu, Xin Sun, Fan Li, Subei Zhang, Kuan Li, Li Li, Junping Wu, Long Xu, Jing Feng, Wen Ning, Zhixue Liu, Huaiyong Chen
Pages: 5271-5280
Published online on: 27 October 2016

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Article

Lipopolysaccharide-induced cytokine expression pattern in peripheral blood mononuclear cells in childhood obesity

Yu Wu, Bin Yue, Jia Liu
Pages: 5281-5287
Published online on: 20 October 2016

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Article

Long non-coding RNA RP5-833A20.1 inhibits proliferation, metastasis and cell cycle progression by suppressing the expression of NFIA in U251 cells

Chun‑Min Kang, Yan‑Wei Hu, Ying Nie, Jia‑Yi Zhao, Shu‑Fen Li, Shuai Chu, Hai‑Xia Li, Qing‑Shui Huang, Yu‑Rong Qiu
Pages: 5288-5296
Published online on: 19 October 2016

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Article

Resveratrol alleviates sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation of Sirt1

Rui An, Lei Zhao, Jian Xu, Cong Xi, Haixun Li, Guohong Shen, Wei Zhang, Shumiao Zhang, Lijun Sun
Pages: 5297-5303
Published online on: 19 October 2016

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Article

Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptor‑positive breast cancer

Wei Gao, Mei‑Hong Wu, Ning Wang, Ming‑Zheng Ying, Ying‑Yi Zhang, Jing Hua, Liu Chuan, Ya‑Jie Wang
Pages: 5304-5310
Published online on: 25 October 2016

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Article

Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes

Guiying Chen, Hong Guo, Ying Song, Huiying Chang, Shaojun Wang, Miaomiao Zhang, Chang Liu
Pages: 5311-5317
Published online on: 26 October 2016

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Article

Identification of serum miRNAs differentially expressed in human epilepsy at seizure onset and post-seizure

Jijun Sun, Weidong Cheng, Lifeng Liu, Shuxin Tao, Zhangyong Xia, Lifeng Qi, Min Huang
Pages: 5318-5324
Published online on: 31 October 2016

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Article

Daidzein impairs Leydig cell testosterone production and Sertoli cell function in neonatal mouse testes: An in vitro study

Yanfeng Zhu, Hua Xu, Min Li, Zhibin Gao, Jie Huang, Linxi Liu, Xiaoming Huang, Yun Li
Pages: 5325-5333
Published online on: 26 October 2016

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Article

Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells

Wenjie Li, Fei Cao, Juan Li, Zhixin Wang, Yu Ren, Zheyong Liang, Peijun Liu
Pages: 5334-5342
Published online on: 20 October 2016

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Article

Inhalation of inactivated‑Mycobacterium phlei prevents asthma‑mediated airway hyperresponsiveness and airway eosinophilia in mice by reducing IL‑5 and IL‑13 levels

Moyu Ming, Zhixi Luo, Shengqiu Lv, Chaoqian Li
Pages: 5343-5349
Published online on: 19 October 2016

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Article

Depletion of complement system immunity in patients with myocardial infarction

Wenwen Yan, Lin Che, Jinfa Jiang, Fan Yang, Qianglin Duan, Haoming Song, Xiaohong Liu, Yuqin Shen, Lemin Wang
Pages: 5350-5356
Published online on: 01 November 2016

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Article

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Bo Li, Xiao‑Li Wang
Pages: 5357-5362
Published online on: 31 October 2016

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Article

Effects of celastrol on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA‑21 and the suppression of the PI3K/Akt‑NF‑κB signaling pathway in an in vitro model of ovarian carcinoma

Haiyan Zhang, Jianhua Li, Guang Li, Surong Wang
Pages: 5363-5368
Published online on: 26 October 2016

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Article

PA-MSHA inhibits proliferation and induces apoptosis in human non-small cell lung cancer cell lines with different genotypes

Xinmin Zhao, Xianghua Wu, Wen Yu, Xuwei Cai, Qi Liu, Xiaolong Fu, Zhebin Liu, Dali Hu, Shiyun Pan, Qiling Huang
Pages: 5369-5376
Published online on: 20 October 2016

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Article

Mechanisms underlying the antiapoptotic and anti-inflammatory effects of monotropein in hydrogen peroxide-treated osteoblasts

Fang‑Bing Zhu, Jian‑Yue Wang, Ying‑Liang Zhang, Yun‑Gen Hu, Zhen‑Shuang Yue, Lin‑Ru Zeng, Wen‑Jie Zheng, Qiao Hou, Shi‑Gui Yan, Ren‑Fu Quan
Pages: 5377-5384
Published online on: 31 October 2016

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Article

Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis

Masaya Kozono, Hirofumi Uto, Rie Ibusuki, Shiho Arima, Kohei Oda, Hiroki Taguchi, Fumisato Sasaki, Yuichiro Nasu, Shinichi Hashimoto, Hitoshi Setoyama, Shuji Kanmura, Masatsugu Numata, Hirohito Tsubouchi, Akio Ido
Pages: 5385-5394
Published online on: 21 October 2016

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Article

Tristetraprolin regulates the decay of the hypoxia-induced vascular endothelial growth factor mRNA in ARPE-19 cells

Jinhyun Ryu, Hyemin Seong, Nal Ae Yoon, Seong Wook Seo, Jeong Woo Park, Sang Soo Kang, Jong Moon Park, Yong Seop Han
Pages: 5395-5400
Published online on: 26 October 2016

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Article

Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome

Katarzyna Ożegowska, Anna Bogacz, Joanna Bartkowiak‑Wieczorek, Agnieszka Seremak‑Mrozikiewicz, Leszek Pawelczyk
Pages: 5401-5407
Published online on: 31 October 2016

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Article

Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats

Junying Bi, Haiyan Zhang, Jing Lu, Weifu Lei
Pages: 5408-5414
Published online on: 01 November 2016

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Article

microRNA-361 targets Wilms' tumor 1 to inhibit the growth, migration and invasion of non-small-cell lung cancer cells

Shuxiang Yang, Yingchao Zhang, Xin Zhao, Jingzheng Wang, Jianjing Shang
Pages: 5415-5421
Published online on: 19 October 2016

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Article

Association of SCNN1B promoter methylation with essential hypertension

Qilong Zhong, Chunyan Liu, Rui Fan, Shiwei Duan, Xuting Xu, Jinshun Zhao, Shuqi Mao, Wen Zhu, Lingmei Hao, Fengying Yin, Lina Zhang
Pages: 5422-5428
Published online on: 31 October 2016

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Correction Open Access

[Corrigendum] Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis

Chao Huang, Hong Liu, Xiuli Gong, Bin Wen, Dan Chen, Jinyuan Liu, Fengliang Hu
Pages: 5429-5429
Published online on: 25 October 2016

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Correction Open Access

[Corrigendum] Integration of gene expression and DNA methylation profiles provides a molecular subtype for risk assessment in atherosclerosis

Sheng‑Chao Ma, Hui‑Ping Zhang, Fan‑Qi Kong, Hui Zhang, Cheng Yang, Yang‑Yang He, Yan‑Hua Wang, An‑Ning Yang, Ju Tian, Xiao‑Ling Yang, Ming‑Hao Zhang, Hua Xu, Yi‑Deng Jiang, Zheng Yu
Pages: 5430-5430
Published online on: 01 November 2016

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Article Open Access

A mutation in β-amyloid precursor protein renders SH‑SY5Y cells vulnerable to isoflurane toxicity: The role of inositol 1,4,5‑trisphosphate receptors

Xiang Liu, Shan Song, Qiujun Wang, Tianbao Yuan, Jihua He
Pages: 5435-5442
Published online on: 08 November 2016

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Rapid and sensitive detection of Plesiomonas shigelloides by cross‑priming amplification of the hugA gene

Shuang Meng, Yi Wang, Yan Wang, Changyun Ye
Pages: 5443-5450
Published online on: 14 November 2016

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Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data

Dadong Wang, Zi‑Man Zhu, Yu‑Liang Tu, Chun‑Qing Dou, Yong Xu, Xiang‑Long Tan, Ming‑Ming Han, Zhuang‑Jie Yang, Xin Jin, Bao Zhang, Shouwang Cai, Zhi‑Wei Liu
Pages: 5451-5460
Published online on: 07 November 2016

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Article Open Access

Presence of multimeric isoforms of human C-reactive protein in tissues and blood

Qiling Li, Wei Xu, Xue Xue, Qi Wang, Lu Han, Wenzhi Li, Shulan Lv, Dong Liu, Jendai Richards, Zhujun Shen, Li Ma, Qing Song
Pages: 5461-5466
Published online on: 03 November 2016

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Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer

Linghui Jiang, Yiqin Wang, Duming Zhu, Zhanggang Xue, Hailei Mao
Pages: 5467-5474
Published online on: 22 November 2016

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Roles of mitochondrial transcription factor A and microRNA‑590‑3p in the development of colon cancer

Kaiming Wu, Zhenxian Zhao, Yinglian Xiao, Jianjun Peng, Jianhui Chen, Yulong He
Pages: 5475-5480
Published online on: 21 November 2016

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Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury

Youguang Gao, Ting Chen, Xianghui Lei, Yunfeng Li, Xingui Dai, Yuanyuan Cao, Qionglei Ding, Xiabao Lei, Tao Li, Xianzhong Lin
Pages: 5481-5488
Published online on: 11 November 2016

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Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection

In Seung Jang, Sun Joo Park
Pages: 5489-5494
Published online on: 16 November 2016

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Article Open Access

NLS‑RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway

Hao Song, Liu Li, Liang Zhong, Rong Yang, Kailing Jiang, Xiaoqun Yang, Beizhong Liu
Pages: 5495-5500
Published online on: 08 November 2016

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Article Open Access

Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women

Simona Ianoşi, Gabriel Ianoşi, Daniela Neagoe, Oana Ionescu, Ovidiu Zlatian, Anca Oana Docea, Corin Badiu, Maria Sifaki, Dimitris Tsoukalas, Aristidis M. Tsatsakis, Demetrios A. Spandidos, Daniela Călina
Pages: 5501-5506
Published online on: 04 November 2016

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Expression pattern of HMGB1 and its association with autophagy in acute necrotizing pancreatitis

Can Yu, Xiao Yu, Hong‑Wei Zhu, Xia Li, Li‑Hua Huang, Zhi‑Qiang Li, Duo Han, Hui Huang
Pages: 5507-5513
Published online on: 15 November 2016

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Synergistic effects of overexpression of BMP‑2 and TGF‑β3 on osteogenic differentiation of bone marrow mesenchymal stem cells

Yilin Wang, Tian He, Jie Liu, Hongzhi Liu, Lugang Zhou, Wei Hao, Yujie Sun, Xin Wang
Pages: 5514-5520
Published online on: 22 November 2016

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Inhibition of the growth of human melanoma cells by methionine enkephalin

Dong‑Mei Wang, Guang‑Chuan Wang, Jing Yang, Nicolas P. Plotnikoff, Noreen Griffin, Yu‑Man Han, Rui‑Qun Qi, Xing‑Hua Gao, Feng‑Ping Shan
Pages: 5521-5527
Published online on: 14 November 2016

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Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways

Xiaohua Shen, Meihui Wang, Xukun Bi, Jiefang Zhang, Shaoxiang Wen, Guosheng Fu, Liang Xia
Pages: 5528-5534
Published online on: 07 November 2016

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LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain

Hongmei Meng, Yuejia Song, Jiyuan Zhu, Qi Liu, Pengtian Lu, Na Ye, Zhen Zhang, Yuxin Pang, Jiping Qi, He Wu
Pages: 5535-5543
Published online on: 07 November 2016

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SirT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16

Guo‑Dong Chen, Wei‑Dong Yu, Xiao‑Ping Chen
Pages: 5544-5550
Published online on: 15 November 2016

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Method for in vitro differentiation of bone marrow mesenchymal stem cells into endothelial progenitor cells and vascular endothelial cells

Qihong Wang, Weifeng Zhang, Guifen He, Huifang Sha, Zhe Quan
Pages: 5551-5555
Published online on: 18 November 2016

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Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury Retraction in /10.3892/mmr.2017.6299

Yunhu Yu, Fang Cao, Qishan Ran, Xiaochuan Sun
Pages: 5556-5566
Published online on: 18 November 2016

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Article

Melatonin attenuates TGFβ1-induced epithelial-mesenchymal transition in lung alveolar epithelial cells

Na Yu, Yi‑Tian Sun, Xin‑Ming Su, Miao He, Bing Dai, Jian Kang
Pages: 5567-5572
Published online on: 16 November 2016

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Article

RNA‑seq profiling of mRNA associated with hypertrophic cardiomyopathy

Chang‑Wei Ren, Jia‑Ji Liu, Jin‑Hua Li, Jing‑Wei Li, Jiang Dai, Yong‑Qiang Lai
Pages: 5573-5586
Published online on: 08 November 2016

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Article

Identification of suitable reference genes for BDV-infected primary rat hippocampal neurons

Qiang Mao, Lujun Zhang, Yujie Guo, Lu Sun, Siwen Liu, Peng He, Rongzhong Huang, Lin Sun, Shigang Chen, Hong Zhang, Peng Xie
Pages: 5587-5594
Published online on: 22 November 2016

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Article

Nobiletin attenuates lipopolysaccharide/D‑galactosamine‑induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF‑κB‑mediated cytokine production

Zhenxing He, Xuanfei Li, Hao Chen, Kun He, Yiming Liu, Junhua Gong, Jianping Gong
Pages: 5595-5600
Published online on: 15 November 2016

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Article

Crocus sativus L. protects against SDS‑induced intestinal damage and extends lifespan in Drosophila melanogaster

Zonglin Liu, Yuchen Chen, Hong Zhang, Li Hua Jin
Pages: 5601-5606
Published online on: 15 November 2016

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Article

Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways

Linlin Chen, Bin Zhang, Shiqiang Shan, Xin Zhao
Pages: 5607-5613
Published online on: 16 November 2016

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Article

Cantharidin induces G2/M arrest and triggers apoptosis in renal cell carcinoma

Yu Ren, Shu‑Wei Zhang, Zhen‑Hua Xie, Xiao‑Ming Xu, Liang‑Liang Chen, Zhong‑Guan Lou, Guo‑Bin Weng, Xu‑Ping Yao
Pages: 5614-5618
Published online on: 23 November 2016

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Article

Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury

Yong Wang, Chunsheng Li, Chunjin Gao, Zhuo Li, Jing Yang, Xuehua Liu, Fang Liang
Pages: 5619-5625
Published online on: 09 November 2016

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Article

Dec1 expression predicts prognosis and the response to temozolomide chemotherapy in patients with glioma

Xiao‑Ming Li, Wei Lin, Jiang Wang, Wei Zhang, An‑An Yin, Yi Huang, Jian Zhang, Libo Yao, Huan Bian, Jing Zhang, Xiang Zhang
Pages: 5626-5636
Published online on: 03 November 2016

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Article

GRIN3A and MAPT stimulate nerve overgrowth in macrodactyly

Xu Shi, Lu Lu, Xiu Jin, Bin Liu, Xiguang Sun, Laijin Lu, Yanfang Jiang
Pages: 5637-5643
Published online on: 03 November 2016

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Article

Distribution, pharmacokinetics and primary metabolism model of tramadol in zebrafish

Huiqin Zhuo, Hongwei Jin, Huifang Peng, Heqing Huang
Pages: 5644-5652
Published online on: 21 November 2016

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Article

Stanniocalcin 2 improved osteoblast differentiation via phosphorylation of ERK

Juan Zhou, Yinghua Li, Lina Yang, Yougen Wu, Yunjiao Zhou, Yunqing Cui, Gong Yang, Yang Hong
Pages: 5653-5659
Published online on: 16 November 2016

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Article

Zoledronic acid overcomes adriamycin resistance in acute myeloid leukemia cells by promoting apoptosis

Rui‑Fang Fan, Yu‑Xin Chen, Zhi‑Gang Fang, Xiao‑Yan Guo, Ying Lu, Ling‑Ling Liu, Yi‑Chuan Xu, Xiang‑Fu Liu, Dong‑Jun Lin
Pages: 5660-5666
Published online on: 21 November 2016

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Article

Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells

Fang Cai, Jianying Li, Yandi Liu, Zunyi Zhang, D. S. Hettiarachchi, Duo Li
Pages: 5667-5676
Published online on: 03 November 2016

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Article

Estrogen is neuroprotective against hypoglycemic injury in murine N38 hypothalamic cells

Tandra R. Chakraborty, Joshua Cohen, Darien Yohanan, Eilliut Alicea, Benjamin S. Weeks, Sanjoy Chakraborty
Pages: 5677-5684
Published online on: 18 November 2016

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Article

Effects of interleukin-1 receptor-associated kinase 1 RNA interference in dendritic cells on inflammatory cytokine release and T-cell proliferation

Yan Gao, Xuxu Xu, Juan Feng, Ying Ma, Dongming Zheng, Yiming Meng, Fengping Shan
Pages: 5685-5692
Published online on: 15 November 2016

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Article

Hsa‑miR‑371‑5p inhibits human mesangial cell proliferation and promotes apoptosis in lupus nephritis by directly targeting hypoxia‑inducible factor 1α

Feifei Yao, Liqiu Sun, Wei Fang, Huamin Wang, Dongsheng Yao, Rui Cui, Jia Xu, Li Wang, Xiumei Wang
Pages: 5693-5698
Published online on: 14 November 2016

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Article

PI3K/Akt signaling is involved in the pathogenesis of bleomycin‑induced pulmonary fibrosis via regulation of epithelial‑mesenchymal transition

Xiao‑Ling Zhang, Rong‑Ge Xing, Liang Chen, Chun‑Rong Liu, Zhi‑Gang Miao
Pages: 5699-5706
Published online on: 22 November 2016

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Article

Obesity‑associated miR‑148a is regulated by cytokines and adipokines via a transcriptional mechanism

Chunmei Shi, Lingxia Pang, Chenbo Ji, Jiaqin Wang, Ning Lin, Jiantao Chen, Ling Chen, Lei Yang, Fangyan Huang, Yahui Zhou, Xirong Guo, Hui Liang, Min Zhang
Pages: 5707-5712
Published online on: 14 November 2016

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Article

Role of perivascular adipose tissue in nicotine‑induced endothelial cell inflammatory responses

Chao‑Nan Wang, Gen‑Huan Yang, Zhan‑Qi Wang, Chang‑Wei Liu, Tian‑Jia Li, Zhi‑Chao Lai, Shi‑Ying Miao, Lin‑Fang Wang, Bao Liu
Pages: 5713-5718
Published online on: 09 November 2016

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Article

Etiopathogenesis of adolescent idiopathic scoliosis: Expression of melatonin receptors 1A/1B, calmodulin and estrogen receptor 2 in deep paravertebral muscles revisited

Josef Zamecnik, Lenka Krskova, Jaromir Hacek, Ivana Stetkarova, Martin Krbec
Pages: 5719-5724
Published online on: 07 November 2016

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Article

Selection of suitable reference genes for gene expression studies in normal human ovarian tissues, borderline ovarian tumours and ovarian cancer

Olumide Ofinran, Ujjal Bose, Daniel Hay, Summi Abdul, Cristina Tufatelli, Raheela Khan
Pages: 5725-5731
Published online on: 08 November 2016

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Article

Temozolomide inhibits cellular growth and motility via targeting ERK signaling in glioma C6 cells

Yingge Wang, Shan Gao, Weiguang Wang, Jingyan Liang
Pages: 5732-5738
Published online on: 23 November 2016

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Article

Alteration of epoxyeicosatrienoic acids in the liver and kidney of cytochrome P450 4F2 transgenic mice

Bijun Zhang, Guangrui Lai, Xiaoliang Liu, Yanyan Zhao
Pages: 5739-5745
Published online on: 23 November 2016

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Article

MicroRNA‑93 is overexpressed and induces apoptosis in glaucoma trabecular meshwork cells

Yansa Wang, Fenghua Li, Shuyun Wang
Pages: 5746-5750
Published online on: 14 November 2016

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Article

Post‑translational modification of CREB‑1 decreases collagen I expression by inhibiting the TGF‑β1 signaling pathway in rat hepatic stellate cells

Xiaoling Deng, Liang Deng, Pei Wang, Chunwei Cheng, Keshu Xu
Pages: 5751-5759
Published online on: 07 November 2016

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Article

Etomidate inhibits nuclear factor-κB through decreased expression of glucocorticoid receptor in septic rats

Yu Zhang, Ruo‑Meng Li, Chun Wang, Na Liu, Shen Lv, Jun‑Yu Xiong
Pages: 5760-5766
Published online on: 16 November 2016

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

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Article Number: 77
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Article Number: 76
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[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
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Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
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[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

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Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

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Article Number: 68
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[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
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[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
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[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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Article Open Access

Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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