Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells

  • Authors:
    • Yu Bai
    • Hong Yang
    • Guoying Zhang
    • Libing Hu
    • Yonghong Lei
    • Yang Qin
    • Yong Yang
    • Qilin Wang
    • Ruiqian Li
    • Qiqi Mao
  • View Affiliations

  • Published online on: December 15, 2016     https://doi.org/10.3892/mmr.2016.6051
  • Pages: 885-889
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Abstract

Resveratrol is a polyphenolic compound, which has been revealed to induce apoptosis in numerous human cancer cells; however, the effects of resveratrol on the migration and invasion of human bladder cancer cells have not been reported. The present study aimed to evaluate the anti‑metastatic potential of resveratrol against bladder cancer and its mechanism of action. The results indicated that resveratrol inhibits the adhesion, migration and invasion of bladder cancer cells in a dose‑dependent manner. Resveratrol was shown to significantly inhibit the expression and secretion of matrix metalloproteinase (MMP)‑2 and MMP‑9 in bladder cancer cells. Furthermore, resveratrol suppressed the phosphorylation of c‑Jun N‑terminal kinase and extracellular signal‑regulated protein kinase. In conclusion, the present study is the first, to the best of our knowledge, to demonstrate that resveratrol may be considered a novel anticancer agent for the treatment of bladder cancer via the inhibition of migration and invasion.
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February-2017
Volume 15 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Bai Y, Yang H, Zhang G, Hu L, Lei Y, Qin Y, Yang Y, Wang Q, Li R, Mao Q, Mao Q, et al: Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells. Mol Med Rep 15: 885-889, 2017
APA
Bai, Y., Yang, H., Zhang, G., Hu, L., Lei, Y., Qin, Y. ... Mao, Q. (2017). Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells. Molecular Medicine Reports, 15, 885-889. https://doi.org/10.3892/mmr.2016.6051
MLA
Bai, Y., Yang, H., Zhang, G., Hu, L., Lei, Y., Qin, Y., Yang, Y., Wang, Q., Li, R., Mao, Q."Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells". Molecular Medicine Reports 15.2 (2017): 885-889.
Chicago
Bai, Y., Yang, H., Zhang, G., Hu, L., Lei, Y., Qin, Y., Yang, Y., Wang, Q., Li, R., Mao, Q."Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells". Molecular Medicine Reports 15, no. 2 (2017): 885-889. https://doi.org/10.3892/mmr.2016.6051