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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2017 Volume 15 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Non‑infective occupational risk factors for hepatocellular carcinoma: A review (Review)

Caterina Ledda, Carla Loreto, Christian Zammit, Andrea Marconi, Lucrezia Fago, Serena Matera, Valentina Costanzo, Giovanni Fuccio Sanzà, Stefano Palmucci, Margherita Ferrante, Chiara Costa, Concettina Fenga, Antonio  Biondi, Cristoforo Pomara, Venerando Rapisarda
Pages: 511-533
Published online on: 14 December 2016

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Article Open Access

Expression of miR‑26a exhibits a negative correlation with HMGA1 and regulates cancer progression by targeting HMGA1 in lung adenocarcinoma cells

Noboru Sekimoto, Ayako Suzuki, Yutaka Suzuki, Sumio Sugano
Pages: 534-542
Published online on: 15 December 2016

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Article Open Access

Advanced oxidation protein products induce apoptosis, and upregulate sclerostin and RANKL expression, in osteocytic MLO-Y4 cells via JNK/p38 MAPK activation

Chaoqun Yu, Dong Huang, Kunyuan Wang, Bochuan Lin, Yuanhang Liu, Songbo Liu, Weichi Wu, Huiru Zhang
Pages: 543-550
Published online on: 14 December 2016

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Article Open Access

Reduced miR‑26a and miR‑26b expression contributes to the pathogenesis of osteoarthritis via the promotion of p65 translocation

Xuefeng Yin, Jiang‑Quan Wang, Shu‑Yi Yan
Pages: 551-558
Published online on: 14 December 2016

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Article Open Access

Involvement of interleukin‑23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis

Nan Ma, Di Yang, Hirohiko Okamura, Jumpei Teramachi, Tomokazu Hasegawa, Lihong Qiu, Tatsuji Haneji
Pages: 559-566
Published online on: 14 December 2016

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Article Open Access

Resveratrol inhibits adventitial fibroblast proliferation and induces cell apoptosis through the SIRT1 pathway

Lin Ling, Shaohua Gu, Yan Cheng
Pages: 567-572
Published online on: 30 December 2016

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Article Open Access

Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy

Zhu‑Hong Zhang, Qing‑Zhong Chen, Feng Jiang, Todd A. Townsend, Chun‑Jie Mao, Cai‑Yun You, Wen‑Hui Yang, Zhi‑Yong Sun, Jin‑Guo Yu, Hua Yan
Pages: 573-580
Published online on: 14 December 2016

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Article Open Access

Genetic heterogeneity in patients with Bartter syndrome type 1

Mingran Sun, Jing Ning, Weihong Xu, Han Zhang, Kaishu Zhao, Wenfu Li, Guiying Li, Shibo Li
Pages: 581-590
Published online on: 21 December 2016

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Article Open Access

Differential expression of microRNA in the lungs of rats with pulmonary arterial hypertension

Tingting Xiao, Lijian Xie, Min Huang, Jie Shen
Pages: 591-596
Published online on: 14 December 2016

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Article Open Access

Role of miR-223/paired box 6 signaling in temozolomide chemoresistance in glioblastoma multiforme cells

Quan Cheng, Xiaoqiang Ma, Hui Cao, Zigui Chen, Xin Wan, Rui Chen, Renjun Peng, Jun Huang, Bing Jiang
Pages: 597-604
Published online on: 27 December 2016

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Article Open Access

Expression and clinical significance of C14orf166 in esophageal squamous cell carcinoma

Yan‑Wu Zhou, Rong Li, Chao‑Jun Duan, Yang Gao, Yuan‑Da Cheng, Zhi‑Wei He, Jun‑Xian Zeng, Chun‑Fang Zhang
Pages: 605-612
Published online on: 16 December 2016

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Article Open Access

Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice Corrigendum in /10.3892/mmr.2021.12448

Yan Xiang, Bing‑Yao Pang, Yuan Zhang, Qiao‑Ling Xie, Ying Zhu, Ai‑Jing Leng, Long‑Qing Lu, Hai‑Long Chen
Pages: 613-626
Published online on: 29 December 2016

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Article Open Access

Fas expression is downregulated in gastric cancer

Xuming Wang, Zhengqi Fu, Ying Chen, Lijiang Liu
Pages: 627-634
Published online on: 14 December 2016

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Article Open Access

Dexmedetomidine may upregulate the expression of caveolin‑1 in lung tissues of rats with sepsis and improve the short‑term outcome

Yun Zhang, Ke Ran, Shu‑Bin Zhang, Lili Jiang, Dan Wang, Zhi‑Jian Li
Pages: 635-642
Published online on: 15 December 2016

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Article Open Access

CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation

Rui Li, Yuan Zhang, Huacheng Yan, Hua Xiao, Yunjun Ruan, Jian Qiu, Lei Shi
Pages: 643-648
Published online on: 14 December 2016

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Article Open Access

Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis

You Yeon Choi, Mi Hye Kim, Kwang Seok Ahn, Jae‑Young Um, Seok‑Geun Lee, Woong Mo Yang
Pages: 649-656
Published online on: 29 December 2016

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Article Open Access

Identification of a novel mutation in the EXT1 gene from a patient with multiple osteochondromas by exome sequencing

Guolin Hong, Xiaoyan Guo, Wei Yan, Qianqian Li, Hailing Zhao, Ping Ma, Xiao Hu
Pages: 657-664
Published online on: 29 December 2016

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Article Open Access

Pallidin protein in neurodevelopment and its relation to the pathogenesis of schizophrenia

Qing Shi, Congmei Li, Kuichen Li, Qin Liu
Pages: 665-672
Published online on: 21 December 2016

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Article Open Access

Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats

Yun Wang, Yu‑Han Gu, Ming Liu, Yang Bai, Huai‑Liang Wang
Pages: 673-680
Published online on: 23 December 2016

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Article Open Access

Antimicrobial resistance development following surgical site infections

Daniela Călina, Anca Oana Docea, Lucica Rosu, Ovidiu Zlatian, Alexandra Floriana Rosu, Florin Anghelina, Otilia Rogoveanu, Andreea Letiția Arsene, Alina Crenguța Nicolae, Cristina Manuela Drăgoi, John Tsiaoussis, Aristides M. Tsatsakis, Demetrios A. Spandidos, Nikolaos Drakoulis, Eliza Gofita
Pages: 681-688
Published online on: 13 December 2016

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Article Open Access

Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Peng Zhang
Pages: 689-695
Published online on: 22 December 2016

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Article Open Access

Downregulation of mouse CCR3 by lentiviral shRNA inhibits proliferation and induces apoptosis of mouse eosinophils

Xin‑Hua Zhu, Bing Liao, Yi Xu, Ke Liu, Yun Huang, Quan‑Long Huang, Yue‑Hui Liu
Pages: 696-702
Published online on: 29 December 2016

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Article Open Access

Downregulation of the β1 adrenergic receptor in the myocardium results in insensitivity to metoprolol and reduces blood pressure in spontaneously hypertensive rats

Yun Huang, Xiao‑Li Liu, Jia Wen, Li‑Hua Huang, Yao Lu, Ru‑Jia Miao, Xing Liu, Ying Li, Xiao‑Wei Xing, Hong Yuan
Pages: 703-711
Published online on: 14 December 2016

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Article Open Access

Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression

Xue‑Shan Zhao, Qi Wu, Juan Peng, Li‑Hong Pan, Zhong Ren, Hui‑Ting Liu, Zhi‑Sheng Jiang, Gui‑Xue Wang, Zhi‑Han Tang, Lu‑Shan Liu
Pages: 712-718
Published online on: 16 December 2016

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Article Open Access

Clinical significance of Wip1 overexpression and its association with the p38MAPK/p53/p16 pathway in NSCLC

Shize Yang, Siyuan Dong, Xiaohan Qu, Xinwen Zhong, Qigang Zhang
Pages: 719-723
Published online on: 13 December 2016

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Article Open Access

Salvianolic acid B reverses multidrug resistance in HCT‑8/VCR human colorectal cancer cells by increasing ROS levels

Piaoting Guo, Songpo Wang, Wei Liang, Wenjing Wang, Huijun Wang, Miaomiao Zhao, Xiaowei Liu
Pages: 724-730
Published online on: 14 December 2016

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Article Open Access

Identification of therapeutic targets for Parkinson's disease via bioinformatics analysis

Na Dong, Xueqing Zhang, Qingjun Liu
Pages: 731-735
Published online on: 14 December 2016

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Article Open Access

Safety and toxicology of the intravenous administration of Ang2‑siRNA plasmid chitosan magnetic nanoparticles

Xiuying Shan, Tingting Xu, Zhaoliang Liu, Xuefeng Hu, Yan‑Ding Zhang, Biao Wang
Pages: 736-742
Published online on: 29 December 2016

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Article Open Access

High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma

Haiping Wang, Gangjun Yuan, Bai Zhao, Yakun Zhao, Yu Qiu
Pages: 743-749
Published online on: 13 December 2016

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Article Open Access

Genome-wide association scans for idiopathic osteonecrosis of the femoral head in a Korean population

Seung‑Hoon Baek, Kang‑Il Kim, Kyung‑Sik Yoon, Tae‑Ho Kim, Shin‑Yoon Kim
Pages: 750-758
Published online on: 14 December 2016

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Article Open Access

The development and biological characteristics of a novel potentially radioresistant inbred mouse strain

Qin Wang, Liqing Du, Yan Wang, Chang Xu, Zhijuan Sun, Yue Fu, Bing Yang, Yueying Wang, Chuanjie Mu, Saijun Fan, Lu Cai, Takanori Katsube, Qiang Liu
Pages: 759-767
Published online on: 22 December 2016

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Article Open Access

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

Xin‑Hong Wang, Xin Xie, Xiao‑Guang Luo, Hong Shang, Zhi‑Yi He
Pages: 768-776
Published online on: 23 December 2016

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Article Open Access

The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma

Moyu Ming, Chaoqian Li, Zhixi Luo, Shengqiu Lv, Qixiang Sun
Pages: 777-783
Published online on: 29 December 2016

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Article Open Access

Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro

Jong Min Baek, Sung‑Jun Ahn, Yoon‑Hee Cheon, Myeung Su Lee, Jaemin Oh, Ju‑Young Kim
Pages: 784-792
Published online on: 23 December 2016

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Article Open Access

Microduplication of 7q36.3 encompassing the SHH long‑range regulator (ZRS) in a patient with triphalangeal thumb‑polysyndactyly syndrome and congenital heart disease

Zhenghua Liu, Ni Yin, Lianghui Gong, Zhiping Tan, Bangliang Yin, Yifeng Yang, Cheng Luo
Pages: 793-797
Published online on: 29 December 2016

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Article

Atorvastatin alleviates renal ischemia-reperfusion injury in rats by promoting M1-M2 transition

Qi Wang, Yan‑Yan Su, Yan‑Qun Li, Yun‑Fang Zhang, Shen Yang, Jie‑Lin Wang, Hong‑Yan Li
Pages: 798-804
Published online on: 23 December 2016

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Article

Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction Retraction in /10.3892/mmr.2025.13622

Xiao Wang, Qin Min Ge, Fan Bian, Yan Dong, Chun Mei Huang
Pages: 805-812
Published online on: 30 December 2016

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Article

SIRT1‑mediated regulation of oxidative stress induced by Pseudomonas aeruginosa lipopolysaccharides in human alveolar epithelial cells

Xiaoli Liu, Tuo Yang, Tieying Sun, Kuiqing Shao
Pages: 813-818
Published online on: 14 December 2016

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Article

Short hairpin RNA directed against β-catenin inhibits prostate cancer growth and invasion in vitro

Jiahui Zhao, Chunting Wu, Yong Luo, Yongguang Jiang
Pages: 819-824
Published online on: 22 December 2016

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Article

Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine

Xiaxia Cai, Lei Bao, Ye Ding, Xiaoqian Dai, Zhaofeng Zhang, Yong Li
Pages: 825-832
Published online on: 15 December 2016

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Article

Influence of microRNA‑34a on proliferation, invasion and metastasis of HCT116 cells

Chunyan Li, Shuming Lu, Yingyan Wang, Shibin Guo, Tianyu Zhao, Xiaosheng Wang, Bo Song
Pages: 833-838
Published online on: 29 December 2016

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Article

Hypomethylation of Agtrap is associated with long-term inhibition of left ventricular hypertrophy in prehypertensive losartan-treated spontaneously hypertensive rats

Ting‑Jun Wang, Gui‑Li Lian, Xu Lin, Hong‑Bin Zhong, Chang‑Sheng Xu, Hua‑Jun Wang, Liang‑Di Xie
Pages: 839-846
Published online on: 14 December 2016

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Article

Correlative analyses of the expression levels of PIAS3, p-SHP2, SOCS1 and SOCS3 with STAT3 activation in human astrocytomas

Li‑Hong Liu, Hong Li, Xiao‑Xin Cheng, Qing‑You Kong, Xiao‑Yan Chen, Mo‑Li Wu, Yan Li, Jia Liu, Cong Li
Pages: 847-852
Published online on: 28 December 2016

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Article

Mechanical stress influences the viability and morphology of human parametrial ligament fibroblasts

Ming Hu, Li Hong, Shasha Hong, Jie Min, Yang Zhao, Qing Yang, Qifan Zhang, Jianming Tang, Yang Li
Pages: 853-858
Published online on: 15 December 2016

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Article

Combined toxicity and underlying mechanisms of a mixture of eight heavy metals

Qi Zhou, Yuanliang Gu, Xia Yue, Guochuan Mao, Yafei Wang, Hong Su, Jin Xu, Hongbo Shi, Baobo Zou, Jinshun Zhao, Renyuan Wang
Pages: 859-866
Published online on: 29 December 2016

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Article

Identification of key genes in colorectal cancer using random walk with restart

Xiaofeng Cui, Kexin Shen, Zhongshi Xie, Tongjun Liu, Haishan Zhang
Pages: 867-872
Published online on: 19 December 2016

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Article

Three-dimensional simulated microgravity culture improves the proliferation and odontogenic differentiation of dental pulp stem cell in PLGA scaffolds implanted in mice

Yanping Li, Lina He, Shuang Pan, Lin Zhang, Weiwei Zhang, Hong Yi, Yumei Niu
Pages: 873-878
Published online on: 14 December 2016

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Article

Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide

Tieying Shan, Tieqiang Shan, Fengli Liu, Haiping Zheng, Guiying Li
Pages: 879-884
Published online on: 28 December 2016

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Article

Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells

Yu Bai, Hong Yang, Guoying Zhang, Libing Hu, Yonghong Lei, Yang Qin, Yong Yang, Qilin Wang, Ruiqian Li, Qiqi Mao
Pages: 885-889
Published online on: 15 December 2016

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Article

Low‑molecular weight fucoidan inhibits the differentiation of osteoclasts and reduces osteoporosis in ovariectomized rats

Xin Jin, Liguo Zhu, Xiulan Li, Jian Jia, Yang Zhang, Xiaolei Sun, Jianxiong Ma, Zhaojie Liu, Xinlong Ma
Pages: 890-898
Published online on: 20 December 2016

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Article

AMPK activators suppress breast cancer cell growth by inhibiting DVL3-facilitated Wnt/β-catenin signaling pathway activity

Yu‑Feng Zou, Chun‑Wei Xie, Shi‑Xin Yang, Jian‑Ping Xiong
Pages: 899-907
Published online on: 29 December 2016

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Article

Modulation of low shear stress‑induced eNOS multi‑site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling

Xiangquan Kong, Xinliang Qu, Bing Li, Zhimei Wang, Yuelin Chao, Xiaomin Jiang, Wen Wu, Shao‑Liang Chen
Pages: 908-914
Published online on: 20 December 2016

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Article

Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma

Min Yao, Xiaomei Wang, Yufeng Zhao, Xiaomeng Wang, Feng Gao
Pages: 915-921
Published online on: 27 December 2016

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Article

MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A

Zheng‑Hao Cao, Jing‑Liang Cheng, Yong Zhang, Chun‑Xiao Bo, Yan‑Liang Li
Pages: 922-928
Published online on: 19 December 2016

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Article

Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway

Ning Yang, Yuying Zhao, Zhipeng Wang, Yu Liu, Yanqiao Zhang
Pages: 929-935
Published online on: 28 December 2016

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Article Open Access

Identification of a missense mutation of COL3A1 in a Chinese family with atypical Ehlers-Danlos syndrome using targeted next-generation sequencing

Wenwen Zhang, Qian Han, Min Zhou, Feng Ran, Tong Qiao, Long Yi, Changjian Liu, Zhao Liu
Pages: 936-940
Published online on: 29 December 2016

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Article

Digitoxin synergizes with sorafenib to inhibit hepatocelluar carcinoma cell growth without inhibiting cell migration

Yijun Xiao, Wei Yan, Libin Guo, Chen Meng, Bin Li, Henrique Neves, Peng‑Chen Chen, Ling Li, Yide Huang, Hang Fai Kwok, Yao Lin
Pages: 941-947
Published online on: 30 December 2016

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Article

MicroRNA‑152 inhibits cell proliferation, migration and invasion by directly targeting MAFB in nasopharyngeal carcinoma Retraction in /10.3892/mmr.2023.12960

Yan Li, Daliu Min, Kai Wang, Shankai Yin, Hongliang Zheng, Liangfa Liu
Pages: 948-956
Published online on: 19 December 2016

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Article

Methyl jasmonate induces the apoptosis of human colorectal cancer cells via downregulation of EZH2 expression by microRNA‑101

Zheng Peng, Yong Zhang
Pages: 957-962
Published online on: 20 December 2016

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Article

PROX1 promotes human glioblastoma cell proliferation and invasion via activation of the nuclear factor-κB signaling pathway

Xuchang Xu, Xuefeng Wan, Xinting Wei
Pages: 963-968
Published online on: 27 December 2016

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Article

TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc

Jun Xiao, Manting Wang, Dawei Xiong, Ying Wang, Qiuyue Li, Jing Zhou, Qinkai Chen
Pages: 969-974
Published online on: 29 December 2016

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Article

Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain

Chuanyin Hu, Yun‑Tao Zhao, Guoping Zhang, Ming‑Feng Xu
Pages: 975-980
Published online on: 23 December 2016

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Therapeutic mechanisms of ibuprofen, prednisone and betamethasone in osteoarthritis

Fenglong Sun, Yaohua Zhang, Qiang Li
Pages: 981-987
Published online on: 22 December 2016

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Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells

Meng‑Di Li, Wan‑Peng Cheng, Min‑Xia Shi, Tang‑Dong Ge, Xiao‑Lin Zheng, Dong‑Yuan Wu, Xiao‑Yan Hu, Jin‑Cheng Luo, Feng‑Lan Li, Hui Li
Pages: 988-994
Published online on: 30 December 2016

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Involvement of DJ‑1 in ischemic preconditioning‑induced delayed cardioprotection in vivo

Huan Wang, Yuan‑Yuan Li, Ling‑Yu Qiu, Yu‑Feng Yan, Zhang‑Ping Liao, He‑Ping Chen
Pages: 995-1001
Published online on: 29 December 2016

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[Corrigendum] Clinical characteristics and the identification of novel mutations of COL1A1 and COL1A2 in 61 Chinese patients with osteogenesis imperfecta

Hao Zhang, Hua Yue, Chun Wang, Weiwei Hu, Jiemei Gu, Jinwei He, Wenzhen Fu, Yunqiu Hu, Miao Li, Zhenlin Zhang
Pages: 1002-1002
Published online on: 30 December 2016

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Review

RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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