Open Access

Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma

  • Authors:
    • Ryota Masuda
    • Hiroshi Kijima
    • Madoka Nito
    • Atsushi Wada
    • Tomohiko Matsuzaki
    • Yoichiro Ikoma
    • Kenei Nakazato
    • Daisuke Masuda
    • Makiko Tanaka
    • Hiroyuki Kobayashi
    • Sadaki Inokuchi
    • Masayuki Iwazaki
  • View Affiliations

  • Published online on: February 28, 2017     https://doi.org/10.3892/mmr.2017.6256
  • Pages: 2067-2073
  • Copyright: © Masuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pathological stage is the most important prognostic factor in patients with lung cancer, and is defined according to the tumor node metastasis classification system. The present study aimed to investigate the clinicopathological significance of lymphatic invasion in 103 patients who underwent surgical resection of lung squamous cell carcinoma (SqCC). The patients were divided into two groups, according to the degree of lymphatic invasion: Those with no or mild lymphatic invasion (ly0‑1) and those with moderate or severe lymphatic invasion (ly2‑3). Ly2‑3 was associated with tumor size (P=0.028), lymph node metastasis (P<0.001), venous invasion (P=0.001) and histological differentiation (P=0.047). Statistical analysis using the Kaplan‑Meier method and the log‑rank test indicated that overall survival was significantly reduced in patients with ly2‑3 compared with those with ly0‑1 (P<0.001). Multivariate analysis identified ly2‑3 as an independent predictor of mortality (hazard ratio, 2.580; 95% confidence interval, 1.376‑4.839). In conclusion, moderate or severe lymphatic invasion (ly2‑3) indicated a high malignant potential and may be considered an independent predictor of poor prognosis in patients with SqCC of the lung.
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April-2017
Volume 15 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Masuda R, Kijima H, Nito M, Wada A, Matsuzaki T, Ikoma Y, Nakazato K, Masuda D, Tanaka M, Kobayashi H, Kobayashi H, et al: Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma. Mol Med Rep 15: 2067-2073, 2017.
APA
Masuda, R., Kijima, H., Nito, M., Wada, A., Matsuzaki, T., Ikoma, Y. ... Iwazaki, M. (2017). Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma. Molecular Medicine Reports, 15, 2067-2073. https://doi.org/10.3892/mmr.2017.6256
MLA
Masuda, R., Kijima, H., Nito, M., Wada, A., Matsuzaki, T., Ikoma, Y., Nakazato, K., Masuda, D., Tanaka, M., Kobayashi, H., Inokuchi, S., Iwazaki, M."Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma". Molecular Medicine Reports 15.4 (2017): 2067-2073.
Chicago
Masuda, R., Kijima, H., Nito, M., Wada, A., Matsuzaki, T., Ikoma, Y., Nakazato, K., Masuda, D., Tanaka, M., Kobayashi, H., Inokuchi, S., Iwazaki, M."Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma". Molecular Medicine Reports 15, no. 4 (2017): 2067-2073. https://doi.org/10.3892/mmr.2017.6256