Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin

  • Authors:
    • Min Zhang
    • Yongfang Jiang
    • Xinqiang Xiao
    • Milin Peng
    • Feng Peng
    • Guozhong Gong
  • View Affiliations

  • Published online on: February 22, 2017     https://doi.org/10.3892/mmr.2017.6229
  • Pages: 2318-2324
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Abstract

The present study aimed to investigate alterations in Toll‑like receptor 4 (TLR4), interferon regulatory factor 5 (IRF5) and interferon‑γ‑inducible protein‑10 (IP‑10), and evaluate whether these factors may be associated with a sustained virological response (SVR) among patients with hepatitis C virus genotype‑1 (HCV‑1) who were treated with peginterferon plus ribavirin (PEG‑IFN‑RBV). A total of 31 Chinese patients infected with HCV‑1 were enrolled in the present study and 25 patients obtained SVR. The expression levels of IP‑10 declined significantly during PEG‑IFN‑RBV therapy at the 24 and 48 week time‑points, compared with the baseline (P<0.005, 0.001 and 0.001, respectively). In addition, it was observed that IRF5 mRNA expression and the number of TLR4+ peripheral blood mononuclear cells exhibited similar correlations with IP‑10 concentration (R2=0.0726, P=0.001, R2=0.1634, P<0.0001, respectively) in the SVR group patients; however, these correlations were not observed to be present in the non‑SVR group patients. In conclusion, the results of the present study suggest that marked alterations in IP‑10, TLR4 and IRF5 expression may serve as indicators for the development of SVR in patients with HCV‑1 treated with PEG‑IFN‑RBV.
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April-2017
Volume 15 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang M, Jiang Y, Xiao X, Peng M, Peng F and Gong G: Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin. Mol Med Rep 15: 2318-2324, 2017
APA
Zhang, M., Jiang, Y., Xiao, X., Peng, M., Peng, F., & Gong, G. (2017). Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin. Molecular Medicine Reports, 15, 2318-2324. https://doi.org/10.3892/mmr.2017.6229
MLA
Zhang, M., Jiang, Y., Xiao, X., Peng, M., Peng, F., Gong, G."Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin". Molecular Medicine Reports 15.4 (2017): 2318-2324.
Chicago
Zhang, M., Jiang, Y., Xiao, X., Peng, M., Peng, F., Gong, G."Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin". Molecular Medicine Reports 15, no. 4 (2017): 2318-2324. https://doi.org/10.3892/mmr.2017.6229