Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers

  • Authors:
    • Caterina Ledda
    • Chiara Costa
    • Serena Matera
    • Beatrice Puglisi
    • Valentina Costanzo
    • Massimo Bracci
    • Concettina Fenga
    • Venerando Rapisarda
    • Carla Loreto
  • View Affiliations

  • Published online on: March 24, 2017     https://doi.org/10.3892/mmr.2017.6384
  • Pages: 3372-3378
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Natural asbestiform fibers are defined ‘naturally occurring asbestos’ (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fibers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fiber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to find any biological markers of its effect. Subjects underwent respiratory function tests and HRCT total chest scanning. Serum IL-1β, IL-6, IL-8 and TNF-α were measured. The presence of PPs was significantly greater in subjects exposed than in the control (25 vs. 2). In subjects exposed to FE, IL-1β and TNF-α values were significantly higher than the controls. The previously observed increase of IL-1β and IL-18 showed a probable involvement of the proteic complex defined inflammosome by FE fibers.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ledda C, Costa C, Matera S, Puglisi B, Costanzo V, Bracci M, Fenga C, Rapisarda V and Loreto C: Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers. Mol Med Rep 15: 3372-3378, 2017.
APA
Ledda, C., Costa, C., Matera, S., Puglisi, B., Costanzo, V., Bracci, M. ... Loreto, C. (2017). Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers. Molecular Medicine Reports, 15, 3372-3378. https://doi.org/10.3892/mmr.2017.6384
MLA
Ledda, C., Costa, C., Matera, S., Puglisi, B., Costanzo, V., Bracci, M., Fenga, C., Rapisarda, V., Loreto, C."Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers". Molecular Medicine Reports 15.5 (2017): 3372-3378.
Chicago
Ledda, C., Costa, C., Matera, S., Puglisi, B., Costanzo, V., Bracci, M., Fenga, C., Rapisarda, V., Loreto, C."Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers". Molecular Medicine Reports 15, no. 5 (2017): 3372-3378. https://doi.org/10.3892/mmr.2017.6384