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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-2017 Volume 15 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part A

Wiktoria Maria Suchorska, Ewelina Augustyniak, Magdalena Richter, Tomasz Trzeciak
Pages: 2387-2401
Published online on: 16 March 2017

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Article Open Access

Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part B

Ewelina Augustyniak, Wiktoria Maria Suchorska, Tomasz Trzeciak, Magdalena Richter
Pages: 2402-2414
Published online on: 16 March 2017

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Article Open Access

Matrine reduces the proliferation of A549 cells via the p53/p21/PCNA/eIF4E signaling pathway

Zhiyan Lu, Youzhang Xiao, Xing Liu, Zaipeng Zhang, Feng Xiao, Yongyi Bi
Pages: 2415-2422
Published online on: 16 March 2017

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Article Open Access

Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage

Jiang Wu, Long Ma, Long Wu, Qunhua Jin
Pages: 2423-2432
Published online on: 03 March 2017

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Article Open Access

Correlation of the expression of YY1 and Fas cell surface death receptor with apoptosis of peripheral blood mononuclear cells, and the development of multiple organ dysfunction in children with sepsis

Judith Reséndiz‑Martínez, Juan Asbun‑Bojalil, Sara Huerta‑Yepez, Mario Vega
Pages: 2433-2442
Published online on: 09 March 2017

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Article Open Access

Dental and periodontal phenotypes of Dlx2 overexpression in mice

Jiewen Dai, Jiawen Si, Ningjuan Ouyang, Jianfei Zhang, Dandan Wu, Xudong Wang, Guofang Shen
Pages: 2443-2450
Published online on: 10 March 2017

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Article Open Access

miR-181a modulates proliferation, migration and autophagy in AGS gastric cancer cells and downregulates MTMR3

Yong Lin, Jing Zhao, Hong Wang, Jie Cao, Yuqiang Nie
Pages: 2451-2456
Published online on: 07 March 2017

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Article Open Access

Resveratrol protects against oxidized low‑density lipoprotein‑induced human umbilical vein endothelial cell apoptosis via inhibition of mitochondrial‑derived oxidative stress

Yujie Liu, Xizhou Chen, Jie Li
Pages: 2457-2464
Published online on: 09 March 2017

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Article Open Access

Tenascin-C expression and its associated pathway in BMSCs following co-culture with mechanically stretched ligament fibroblasts

Bing Zhao, Mengcai Hu, Huiyan Wu, Chenchen Ren, Jianshe Wang, Shihong Cui
Pages: 2465-2472
Published online on: 15 March 2017

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Article Open Access

Vitamin K2 promotes mesenchymal stem cell differentiation by inhibiting miR‑133a expression

Yuelei Zhang, Shiyang Weng, Junhui Yin, Hao Ding, Changqing Zhang, Youshui Gao
Pages: 2473-2480
Published online on: 09 March 2017

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Article Open Access

Tetramethylpyrazine-mediated regulation of CXCR4 in retinoblastoma is sensitive to cell density

Nandan Wu, Lijun Xu, Ying Yang, Na Yu, Zhang Zhang, Pei Chen, Jing Zhang, Mingjun Tang, Meng Yuan, Jian Ge, Keming Yu, Jing Zhuang
Pages: 2481-2488
Published online on: 07 March 2017

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Article Open Access

A three-caller pipeline for variant analysis of cancer whole-exome sequencing data

Ze‑Kun Liu, Yu‑Kui Shang, Zhi‑Nan Chen, Huijie Bian
Pages: 2489-2494
Published online on: 16 March 2017

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Article Open Access

Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease

Kamonlak Leecharoenkiat, Yuka Tanaka, Yasuko Harada, Porntip Chaichompoo, Orawan Sarakul, Yasunobu Abe, Duncan Richard Smith, Suthat Fucharoen, Saovaros Svasti, Tsukuru Umemura
Pages: 2495-2502
Published online on: 15 March 2017

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Article Open Access

Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia

Runqin Li, Juan Wu, Junlin He, Yingxiong Wang, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yan Su, Wenqi Chen, Chen Zhang, Rufei Gao
Pages: 2503-2510
Published online on: 14 March 2017

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Article Open Access

Islet-1 induces the differentiation of mesenchymal stem cells into cardiomyocyte-like cells through the regulation of Gcn5 and DNMT-1

Qin Yi, Hao Xu, Ke Yang, Yue Wang, Bin Tan, Jie Tian, Jing Zhu
Pages: 2511-2520
Published online on: 16 March 2017

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Article Open Access

p75 neurotrophin receptor: A potential surface marker of tongue squamous cell carcinoma stem cells

Dongdong Tong, Jing Sun, Ping Huang, Minqi Li, Fenghe Zhang
Pages: 2521-2529
Published online on: 07 March 2017

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Article Open Access

High mobility group box 1 induces calcification of aortic valve interstitial cells via toll-like receptor 4

Wenjun Shen, Jianqing Zhou, Chaoyang Wang, Guangze Xu, Ying Wu, Zhaohui Hu
Pages: 2530-2536
Published online on: 03 March 2017

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Article Open Access

Bone morphogenetic protein 9 stimulates callus formation in osteoporotic rats during fracture healing

Xing Wang, Jun Huang, Fan Huang, Jian‑Chun Zong, Xi Tang, Yang Liu, Qiong‑Fang Zhang, Yang Wang, Liang Chen, Liang‑Jun Yin, Bai‑Cheng He, Zhong‑Liang Deng
Pages: 2537-2545
Published online on: 09 March 2017

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Article Open Access

Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention

Zhi-Ming Tang, Xiao-Xiang Zhai, Ji-Cun Ding
Pages: 2546-2550
Published online on: 16 March 2017

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Article Open Access

Biological effects of bone marrow mesenchymal stem cells on hepatitis B virus in vitro

Wei‑Ping Zheng, Bo‑Ya Zhang, Zhong‑Yang Shen, Ming‑Li Yin, Yi Cao, Hong‑Li Song
Pages: 2551-2559
Published online on: 15 March 2017

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Article Open Access

Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy

Zhuojia Xu, Zongli Diao, Ruixia Liu, Wenhu Liu
Pages: 2560-2566
Published online on: 09 March 2017

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Article Open Access

High expression of ubiquitin-specific peptidase 39 is associated with the development of vascular remodeling

Shuai He, Wei Zhong, Li Yin, Yifei Wang, Zhibing Qiu, Gang Song
Pages: 2567-2573
Published online on: 08 March 2017

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Article Open Access

Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway

Xiurong Li, Yuhuai Lan, Yan Wang, Minghao Nie, Yanhong Lu, Eryang Zhao
Pages: 2574-2582
Published online on: 14 March 2017

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Article Open Access

Negative regulation of ERK1/2 by PI3K is required for the protective effects of Pyropia yezoensis peptide against perfluorooctane sulfonate-induced endoplasmic reticulum stress

Jeong Hwan Oh, Eun‑Young Kim, Youn Hee Choi, Taek‑Jeong Nam
Pages: 2583-2587
Published online on: 03 March 2017

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Article Open Access

Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation

Sisi Yang, Zhe Chen, Ming Cao, Renjie Li, Zhigang Wang, Muxun Zhang
Pages: 2588-2594
Published online on: 16 March 2017

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Article Open Access

PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells

Shuang Zhang, Yanan Liu, Zhenglian Wang, Jingxian Liu, Zhengtao Gu, Qiulin Xu, Lei Su
Pages: 2595-2603
Published online on: 09 March 2017

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Article Open Access

Vatalanib, a tyrosine kinase inhibitor, decreases hepatic fibrosis and sinusoidal capillarization in CCl4-induced fibrotic mice

Ling‑Jian Kong, Hao Li, Ya‑Ju Du, Feng‑Hua Pei, Ying Hu, Liao‑Liao Zhao, Jing Chen
Pages: 2604-2610
Published online on: 15 March 2017

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Article Open Access

Toxicity study of oxalicumone A, derived from a marine-derived fungus Penicillium oxalicum, in cultured renal epithelial cells

Si Shi, Kunbin Guo, Xiangyu Wang, Hao Chen, Jianbin Min, Shuhua Qi, Wei Zhao, Weirong Li
Pages: 2611-2619
Published online on: 03 March 2017

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Article

Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

Hong‑Yan Shen, Lan‑Zhen Li, Ke‑Cheng Xue, Dan‑Dan Hu, Yu‑Jun Gao
Pages: 2620-2624
Published online on: 16 March 2017

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Article

Repression of the expression of TET2 by ZEB1 contributes to invasion and growth in glioma cells

Bo Chen, Yanqing Lei, Hongquan Wang, Yanwei Dang, Peihai Fang, Jun Wang, Jinbo Yang, Lijun Liu
Pages: 2625-2632
Published online on: 03 March 2017

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Article

Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines

Yong‑Zheng Xie, Wan‑Li Ma, Ji‑Ming Meng, Xue‑Qun Ren
Pages: 2633-2642
Published online on: 09 March 2017

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Article

Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia

Ying Liang, Haiqing Gao, Jian Wang, Quanzhen Wang, Shaohua Zhao, Jun Zhang, Jie Qiu
Pages: 2643-2652
Published online on: 07 March 2017

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Article

Lycium barbarum polysaccharide exhibits cardioprotection in an experimental model of ischemia-reperfusion damage

Ya‑Min Hou, Jie Wang, Xian‑Zhao Zhang
Pages: 2653-2658
Published online on: 07 March 2017

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Article

Binding of circulating anti-MUC1 antibody and serum MUC1 antigen in stage IV breast cancer

Yan Tang, Xiuxia Cui, Han Xiao, Shengkun Qi, Xiaoping Hu, Qiong Yu, Guang Shi, Xue Zhang, Jiaying Gu, Yongli Yu, Liying Wang, Yarong Li
Pages: 2659-2664
Published online on: 15 March 2017

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Article

Wiryeongtang regulates hypertonicity-induced expression of aquaporin-2 water channels in mIMCD-3 cells

Mi Gyeong Kim, Yun Jung Lee, Eun Sik Choi, Jung Joo Yoon, Byung Hyuk Han, Dae Gill Kang, Ho Sub Lee
Pages: 2665-2672
Published online on: 07 March 2017

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Article

Advanced glycation end products‑induced mitochondrial energy metabolism dysfunction alters proliferation of human umbilical vein endothelial cells

Yuan Li, Ye Chang, Ning Ye, Yintao Chen, Naijin Zhang, Yingxian Sun
Pages: 2673-2680
Published online on: 10 March 2017

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Article

Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes

Chang Taek Oh, Yu‑Jin Jang, Tae‑Rin Kwon, Songi Im, Soon Re Kim, Joon Seok, Gun‑Yong Kim, Young‑Heui Kim, Seog Kyun Mun, Beom Joon Kim
Pages: 2681-2688
Published online on: 09 March 2017

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Article

Effects of gap junction intercellular communication on the docetaxel-induced cytotoxicity in rat hepatocytes

Nan Tang, Jinghua Liu, Bo Chen, Yuan Zhang, Meiling Yu, Ziqing Cai, Hongpeng Chen
Pages: 2689-2694
Published online on: 07 March 2017

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Article

17β-estradiol protects against doxorubicin-induced cardiotoxicity in male Sprague-Dawley rats by regulating NADPH oxidase and apoptosis genes

Xiao‑Juan Zhang, Xiao‑Qing Cao, Chun‑Sheng Zhang, Zhuo Zhao
Pages: 2695-2702
Published online on: 16 March 2017

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Article

BmK CT and 125I-BmK CT suppress the invasion of glioma cells in vitro via matrix metalloproteinase-2

Na Sun, Lingzhou Zhao, Wenli Qiao, Yan Xing, Jinhua Zhao
Pages: 2703-2708
Published online on: 03 March 2017

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Article

High-resolution single nucleotide polymorphism arrays identified an atypical microdeletion of the Williams-Beuren syndrome interval in a patient presenting with a different phenotype

Shijun Hu, Yifeng Yang, Lin Liu, Zhiping Tan, Tianli Zhao
Pages: 2709-2712
Published online on: 03 March 2017

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Article

miR-21 inhibitor suppresses cell proliferation and colony formation through regulating the PTEN/AKT pathway and improves paclitaxel sensitivity in cervical cancer cells

Guohui Du, Dongmei Cao, Lingzheng Meng
Pages: 2713-2719
Published online on: 16 March 2017

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Article

Upregulation of RASAL2 promotes proliferation and metastasis, and is targeted by miR-203 in hepatocellular carcinoma

Jian‑Feng Fang, Hai‑Ping Zhao, Zheng‑Fei Wang, Shu‑Sen Zheng
Pages: 2720-2726
Published online on: 14 March 2017

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Article

Association between myocardial cell apoptosis and calpain-1/caspase-3 expression in rats with hypoxic-ischemic brain damage

Hong Zhao, Mei Xu, Guilan Chu
Pages: 2727-2731
Published online on: 16 March 2017

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Article

Inhibition of aldose reductase ameliorates ethanol‑induced steatosis in HepG2 cells

Longxin Qiu, Chengchao Cai, Xiangqian Zhao, Yan Fang, Weibiao Tang, Chang Guo
Pages: 2732-2736
Published online on: 10 March 2017

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Article

Hepatocyte growth factor inhibits tubular epithelial‑myofibroblast transdifferentiation by suppression of angiotensin II via the JAK2/STAT3 signaling pathway

Hong‑Yue Wang, Chen Zhang, Qing‑Fei Xiao, Hai‑Chuan Dou, Yan Chen, Chun‑Mei Gu, Ming‑Ji Cui
Pages: 2737-2743
Published online on: 09 March 2017

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Article

Role of histone deacetylase expression levels and activity in the inflammatory responses of patients with chronic hepatitis B

Haiyue Zhang, Xun Li, Qian Zhang, Fan Yang, Xiaogang Chu, Di Zhang, Luwen Wang, Zuojiong Gong
Pages: 2744-2752
Published online on: 07 March 2017

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Article

Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/β-catenin pathway

Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G. Han, Xu Dong, Yiping Lu, Mintao Zhou
Pages: 2753-2759
Published online on: 13 March 2017

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Article

Novel compound heterozygous PLEC mutations lead to early‑onset limb‑girdle muscular dystrophy 2Q

Jingzi Zhong, Gang Chen, Yiwu Dang, Haixia Liao, Jiapeng Zhang, Dan Lan
Pages: 2760-2764
Published online on: 09 March 2017

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Article Open Access

Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels

Jian Hui Xu, Xing Zhen Liu, Wei Pan, Da Jin Zou
Pages: 2765-2787
Published online on: 14 March 2017

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Article

High glucose promotes the osteogenic differentiation capability of human periodontal ligament fibroblasts

Sujiwan Seubbuk, Hathaitip Sritanaudomchai, Julalux Kasetsuwan, Rudee Surarit
Pages: 2788-2794
Published online on: 16 March 2017

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Article

Neural precursor cell expressed, developmentally downregulated 8‑activating enzyme inhibitor MLN4924 sensitizes colorectal cancer cells to oxaliplatin by inducing DNA damage, G2 cell cycle arrest and apoptosis

Wanwei Zheng, Zhongguang Luo, Jun Zhang, Pei Min, Wenshuai Li, Diannan Xu, Ziqiang Zhang, Panpan Xiong, Hong Liang, Jie Liu
Pages: 2795-2801
Published online on: 09 March 2017

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Article

Expression levels of resistant genes affect cervical cancer prognosis

Fengmei Yang, Bo Gao, Rui Li, Wencui Li, Wei Chen, Zongtao Yu, Jicai Zhang
Pages: 2802-2806
Published online on: 15 March 2017

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Article

Investigation of hypoglycemic, hypolipidemic and anti‑nephritic activities of Paecilomyces tenuipesN45 in diet/streptozotocin‑induced diabetic rats

Chungang Liu, Xuerui Zeng, Yi Li, Hongli Ma, Jingjing Song, Yuhuan Li, Yulin Zhou, Robert J. Lee, Di Wang
Pages: 2807-2813
Published online on: 10 March 2017

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Article

Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression

Kyu‑Shik Lee, So‑Young Chun, Yun‑Suk Kwon, Soyoung Kim, Kyung‑Soo Nam
Pages: 2814-2822
Published online on: 13 March 2017

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Article

Diosgenin inhibits angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts through regulating the TGF‑β1/Smad3 signaling pathway

Hong‑Tao Zhou, Xue‑Fang Yu, Gui‑Ming Zhou
Pages: 2823-2828
Published online on: 03 March 2017

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Article

Molecular characterization of metastatic osteosarcoma: Differentially expressed genes, transcription factors and microRNAs

Lisong Heng, Zhen Jia, Jie Bai, Kun Zhang, Yangjun Zhu, Jianbing Ma, Jun Zhang, Honghao Duan
Pages: 2829-2836
Published online on: 03 March 2017

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Article

MicroRNA-1 upregulation promotes myocardiocyte proliferation and suppresses apoptosis during heart development

Liping Liu, Yonghua Yuan, Xuehua He, Xiaohui Xia, Xiaoyang Mo
Pages: 2837-2842
Published online on: 03 March 2017

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Article

Prevalence and genotypic distribution of GB virus C and torque teno virus among patients undergoing hemodialysis

Hanggoro Tri Rinonce, Yoshihiko Yano, Takako Utsumi, Didik Setyo Heriyanto, Nungki Anggorowati, Dewiyani Indah Widasari, Ahmad Ghozali, Totok Utoro, Maria Inge Lusida, Soetjipto, Heru Prasanto, Yoshitake Hayashi
Pages: 2843-2852
Published online on: 03 March 2017

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Article

Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells

Li Zeng, Xiao‑Feng Rong, Rong‑Heng Li, Xing‑Ye Wu
Pages: 2853-2858
Published online on: 10 March 2017

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Article

Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease

Ping Shao, Xiaoxin Wu, Hongbo Li, Zhigang Wu, Zongxin Yang, Hangping Yao
Pages: 2859-2866
Published online on: 15 March 2017

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Article

Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages

Hironori Yoshino, Yu Kumai, Ikuo Kashiwakura
Pages: 2867-2872
Published online on: 08 March 2017

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Article

Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-α gene expression and cytokine release in vitro

Geórgia Muccillo Dexheimer, Luciana Knabben de Oliveira Becker Delving, Henrique Sulzbach de Oliveira, Vanderlei Biolchi, Márcia Inês Goettert, Adriane Pozzobon
Pages: 2873-2880
Published online on: 14 March 2017

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Article

Inhibition of heat shock protein 70 intensifies heat-stressed damage and apoptosis of chicken primary myocardial cells in vitro

Jiao Xu, Shu Tang, Erbao Song, Bin Yin, Endong Bao
Pages: 2881-2889
Published online on: 16 March 2017

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Article

Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway

Xi Chen, Jianmin Guo, Yu Yuan, Zhongguang Sun, Binglin Chen, Xiaoyang Tong, Lingli Zhang, Chao Shen, Jun Zou
Pages: 2890-2896
Published online on: 15 March 2017

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Retraction Open Access

[Retracted] Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury

Yunhu Yu, Fang Cao, Qishan Ran, Xiaochuan Sun
Pages: 2897-2897
Published online on: 08 March 2017

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Review

Role of autophagy in advanced atherosclerosis (Review)

Yu‑Ning Zhu, Wen‑Jing Fan, Chi Zhang, Fang Guo, Wei Li, Yu‑Fei Wang, Zhi‑Sheng Jiang, Shun‑Lin Qu
Pages: 2903-2908
Published online on: 28 March 2017

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Review

Viral and host factors associated with outcomes of hepatitis C virus infection (Review)

Zehui Yan, Yuming Wang
Pages: 2909-2924
Published online on: 22 March 2017

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Review

iRGD as a tumor‑penetrating peptide for cancer therapy (Review)

Hong Yin, Jie Yang, Qing Zhang, Haiyu Wang, Jinjing Xu, Junnian Zheng
Pages: 2925-2930
Published online on: 30 March 2017

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Review Open Access

Clinical significance of sCD163 and its possible role in asthma (Review)

Yue Zhi, Peng Gao, Xiuqin Xin, Wei Li, Lei Ji, Lin Zhang, Xueyang Zhang, Jie Zhang
Pages: 2931-2939
Published online on: 24 March 2017

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Article Open Access

Comparative evaluation of the effects of platelet‑rich plasma formulations on extracellular matrix formation and the NF‑κB signaling pathway in human articular chondrocytes

Wenjing Yin, Haitao Xu, Jiagen Sheng, Zhengliang Xu, Xuetao Xie, Changqing Zhang
Pages: 2940-2948
Published online on: 23 March 2017

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Article Open Access

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

Tran Duong Thuy, Nam Nhut Phan, Chih-Yang Wang, Han-Gang Yu, Shu-Yin Wang, Pung-Ling Huang, Yi-Yin Do, Yen-Chang Lin
Pages: 2949-2956
Published online on: 30 March 2017

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Article Open Access

Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer

Maren Bredemeier, Sabine Kasimir‑Bauer, Hans‑Christian Kolberg, Thomas Herold, Sarah Synoracki, Siegfried Hauch, Philippos Edimiris, Agnes Bankfalvi, Mitra Tewes, Rainer Kimmig, Bahriye Aktas
Pages: 2957-2968
Published online on: 30 March 2017

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Article Open Access

ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway

Fei Yu, Yan Sun, Jiachen Yu, Zhen Ding, Jinrong Wang, Lanyun Zhang, Tiejing Zhang, Yun Bai, Yulin Wang
Pages: 2969-2976
Published online on: 30 March 2017

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Article Open Access

Identification of two novel mutations in the SLCO2A1 prostaglandin transporter gene in a Chinese patient with primary hypertrophic osteoarthropathy

Ting Guo, Kai Yang, Lv Liu, Zhi‑Ping Tan, Hong Luo
Pages: 2977-2982
Published online on: 24 March 2017

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Article Open Access

Erythromycin attenuates metalloprotease/anti-metalloprotease imbalance in cigarette smoke-induced emphysema in rats via the mitogen-activated protein kinase/nuclear factor-κB activation pathway

Xiaoming Zhou, Dongxue Gu, Gang Hou
Pages: 2983-2990
Published online on: 30 March 2017

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Article Open Access

Expression levels of transcription factors c-Fos and c-Jun and transmembrane protein HAb18G/CD147 in urothelial carcinoma of the bladder

Muren Huhe, Shuangshuang Liu, Yang Zhang, Zheng Zhang, Zhinan Chen
Pages: 2991-3000
Published online on: 30 March 2017

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Article Open Access

Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury

Ting‑Qin Huang, Jin‑Ning Song, Feng‑Wei Zheng, Hong‑Gang Pang, Yong‑Lin Zhao, Hua Gu, Jun‑Jie Zhao
Pages: 3001-3010
Published online on: 22 March 2017

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Article Open Access

Duration of simulated microgravity affects the differentiation of mesenchymal stem cells

Li Xue, Yaohui Li, Jun Chen
Pages: 3011-3018
Published online on: 22 March 2017

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Article Open Access

AhR‑E2F1‑KGFR signaling is involved in KGF‑induced intestinal epithelial cell proliferation

Kunqiu Yang, Jiuheng Yin, Baifa Sheng, Qimeng Wang, Bin Han, Aimin Pu, Min Yu, Lihua Sun, Weidong Xiao, Hua Yang
Pages: 3019-3026
Published online on: 23 March 2017

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Article Open Access

Cibotium barometz polysaccharides stimulate chondrocyte proliferation in vitro by promoting G1/S cell cycle transition

Changlong Fu, Chunsong Zheng, Jie Lin, Jinxia Ye, Yangyang Mei, Caibin Pan, Guangwen Wu, Xihai Li, Hongzhi Ye, Xianxiang Liu
Pages: 3027-3034
Published online on: 30 March 2017

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Article Open Access

Substance P accelerates wound healing in type 2 diabetic mice through endothelial progenitor cell mobilization and Yes-associated protein activation

Jihyun Um, Jinyeong Yu, Ki‑Sook Park
Pages: 3035-3040
Published online on: 21 March 2017

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Article Open Access

The role of miR‑370 in fibrosis after myocardial infarction

Hui Yuan, Jie Gao
Pages: 3041-3047
Published online on: 27 March 2017

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Article Open Access

Lentivirus‑mediated overexpression of CD97/ADGRE5 reverses dysregulated high glucose‑induced endothelial cell migration

Wenting Zhao, Zhen Wang, Zewei Sun, Shuai Wang, Mingjie Wu, Liangrong Zheng
Pages: 3048-3054
Published online on: 30 March 2017

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Article Open Access

Reduction of miR‑132‑3p contributes to gastric cancer proliferation by targeting MUC13

Liang He, Linlin Qu, Lijing Wei, Yan Chen, Jian Suo
Pages: 3055-3061
Published online on: 22 March 2017

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Article Open Access

HMGB1 induces lung fibroblast to myofibroblast differentiation through NF‑κB‑mediated TGF‑β1 release

Qiong Wang, Jun Wang, Junfang Wang, Shanchao Hong, Feifei Han, Jingyu Chen, Guoqian Chen
Pages: 3062-3068
Published online on: 23 March 2017

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Article Open Access

GPR143 mutations in Chinese patients with ocular albinism type 1

Xiuhua Jia, Jin Yuan, Xiaoyun Jia, Shiqi Ling, Shiqiang Li, Xiangming Guo
Pages: 3069-3075
Published online on: 23 March 2017

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Article Open Access

Low shear stress‑induced autophagy alleviates cell apoptosis in HUVECs

Guo Dong, Shusen Yang, Xuefei Cao, Nannan Yu, Jiangbo Yu, Xiufen Qu
Pages: 3076-3082
Published online on: 28 March 2017

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Article

2‑Deoxy‑D‑glucose initiates hepatocyte differentiation in human induced pluripotent stem cells

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Pages: 3083-3087
Published online on: 28 March 2017

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Article

Oncostatin M in William's E medium is suitable for initiation of hepatocyte differentiation in human induced pluripotent stem cells

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Pages: 3088-3092
Published online on: 28 March 2017

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Article

Cerebral hemorrhage therapy by targeting VEGF and HGF in a preclinical trial in rats

Xueqing Li, Ruiqi Cao, Huaihai Lu, Wenbin Tian, Ning Yu, Pei Zhang, Zhenming Dong
Pages: 3093-3098
Published online on: 22 March 2017

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Article

Increased phosphorylation of 4E‑binding protein 1 predicts poor prognosis for patients with colorectal cancer

Yufeng Miao, Lige Chen, Cuifen Shi, Rengen Fan, Ping Chen, Hongqi Liu, Aihua Xia, Haixin Qian
Pages: 3099-3104
Published online on: 22 March 2017

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Article

Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress‑associated gene expression in retinal pigment epithelial cells

Xintong Jiang, Yantao Wei, Ting Zhang, Zhaotian Zhang, Suo Qiu, Xuezhi Zhou, Shaochong Zhang
Pages: 3105-3110
Published online on: 30 March 2017

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Article

Identification of proteins in the aqueous humor associated with cataract development using iTRAQ methodology

Minhong Xiang, Xingru Zhang, Qingsong Li, Hanmin Wang, Zhenyong Zhang, Zhumei Han, Meiqing Ke, Xingxing Chen
Pages: 3111-3120
Published online on: 21 March 2017

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Article

Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats

Hai‑Bing Peng, Rui‑Xun Wang, Hai‑Jing Deng, Yong‑Heng Wang, Jun‑Dong Tang, Fu‑Yuan Cao, Jian‑Hui Wang
Pages: 3121-3128
Published online on: 28 March 2017

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Article

LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease

Chao Gu, Yaqing Li, Jialiang Liu, Xiwang Ying, Yuanshun Liu, Jianping Yan, Chun Chen, Hongbin Zhou, Liming Cao, Yingyu Ma
Pages: 3129-3134
Published online on: 23 March 2017

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Article

Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats

Yang Bai, Yun Wang, Ming Liu, Yu‑Han Gu, Bin Jiang, Xu Wu, Huai‑Liang Wang
Pages: 3135-3142
Published online on: 22 March 2017

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Article

Inhibitory effect of Angelica gigas on cold‑induced RhoA activation in vascular cells

Kangwook Lee, Min Soo Chae, Sung‑Gook Cho, Ho Yeon Go, Seung‑Ho Sun, Junbock Jang, Ki‑Yong Jung, You‑Kyung Choi, Yun‑Kyung Song, Sung Yong Sim, Hye Lim Lee, Mi Suk Kang, Chan‑Yong Jeon, Seong Gyu Ko
Pages: 3143-3146
Published online on: 28 March 2017

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Article

Extravasated platelet aggregation in the livers of rats with drug‑induced hepatic sinusoidal obstruction syndrome

Miki Hirata, Hidehiro Tajima, Tomoharu Miyashita, Takashi Miyata, Shinichi Nakanuma, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Hiroki Nakata, Shoichi Iseki, Shinichi Harada, Tomohiko Wakayama, Tetsuo Ohta
Pages: 3147-3152
Published online on: 28 March 2017

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Article

Inhibition of farnesyl pyrophosphate synthase attenuates high glucose‑induced vascular smooth muscle cells proliferation

Guo‑Ping Chen, Xiao‑Qin Zhang, Tao Wu, Jie Han, Dan Ye
Pages: 3153-3160
Published online on: 23 March 2017

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Article

Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays

Xiaohui Zhu, Yangdong Sun, Chenggang Zhang, Haifeng Liu
Pages: 3161-3171
Published online on: 22 March 2017

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Article

Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats

Tao Peng, Xiangdi Chang, Jie Wang, Junhui Zhen, Xiangdong Yang, Zhao Hu
Pages: 3172-3178
Published online on: 22 March 2017

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Article

Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury

Jianyu Zhou, Jingxia Wang, Wei Li, Chenglong Wang, Li Wu, Jianjun Zhang
Pages: 3179-3185
Published online on: 24 March 2017

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Article

Effects of remote ischemic post‑conditioning on fracture healing in rats

Meng Zhou, Shibao Lu, Guowei Lu, Jiang Huang, Limin Liu, Shuai An, Zheng Li, Huiliang Shen
Pages: 3186-3192
Published online on: 22 March 2017

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Article

Exome sequencing reveals novel IRXI mutation in congenital heart disease

Changlong Guo, Qidi Wang, Yuting Wang, Liping Yang, Haiyan Luo, Xiao Fang Cao, Lisha An, Yue Qiu, Meng Du, Xu Ma, Hui Li, Cailing Lu
Pages: 3193-3197
Published online on: 30 March 2017

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Article

TGFBI gene mutations analysis in Chinese families with corneal dystrophies

Xiaojuan Wang, Ming Ying, Changbo Fu, Yuchuan Wang, Ningdong Li
Pages: 3198-3202
Published online on: 30 March 2017

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Article

Detection assay for HPV16 and HPV18 by loop‑mediated isothermal amplification with lateral flow dipstick tests

Ratchanida Kumvongpin, Patcharee Jearanaikoon, Chotchana Wilailuckana, Nattaya Sae‑Ung, Prinya Prasongdee, Sakda Daduang, Metee Wongsena, Patcharee Boonsiri, Wansika Kiatpathomchai, Sukumarn Sanersak Swangvaree, Alisa Sandee, Jureerut Daduang
Pages: 3203-3209
Published online on: 23 March 2017

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Article

Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1

Chen Liu, Chaoyu Mu, Zeng Li, Liang Xu
Pages: 3210-3214
Published online on: 28 March 2017

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Article

Hypothalamo‑hypophysial system in rats with autotransplantation of the adrenal cortex

Nae Takizawa, Susumu Tanaka, Souichi Oe, Taro Koike, Tadashi Matsuda, Hisao Yamada
Pages: 3215-3221
Published online on: 24 March 2017

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Article

Nationwide survey of Baller‑Gerold syndrome in Japanese population

Hideo Kaneko, Rie Izumi, Hirotsugu Oda, Osamu Ohara, Kiyoko Sameshima, Hidenori Ohnishi, Toshiyuki Fukao, Michinori Funato
Pages: 3222-3224
Published online on: 28 March 2017

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Article

Effects of autophagy and endocytosis on the activity of matrix metalloproteinase‑2 in human renal proximal tubular cells under hypoxia

Wenmin Yu, Zhi Wang, Yiping Li, Lei Liu, Jing Liu, Fenggan Ding, Xiaoyi Zhang, Zhengyuan Cheng, Pingsheng Chen
Pages: 3225-3230
Published online on: 22 March 2017

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Article

Reduced expression of miR‑205‑5p promotes apoptosis and inhibits proliferation and invasion in lung cancer A549 cells by upregulation of ZEB2 and downregulation of erbB3

Min Jiang, Ting Zhong, Wei Zhang, Zuke Xiao, Guozhu Hu, Hong Zhou, Haibin Kuang
Pages: 3231-3238
Published online on: 28 March 2017

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Article

Bone marrow mesenchymal stem cells accelerate the hyperglycemic refractory wound healing by inhibiting an excessive inflammatory response

Wenbin Nan, Zhihao Xu, Zhibin Chen, Xin Yuan, Juntang Lin, Huigen Feng, Jie Lian, Hongli Chen
Pages: 3239-3244
Published online on: 28 March 2017

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Article

MicroRNA‑499 rs3746444 A/G polymorphism functions as a biomarker to predict recurrence following endoscopic submucosal dissection in primary early gastric cancer

Huiyong Shi, Xiangshan Yang, Yanan Zhen, Shoujun Huo, Ruixue Xiao, Zhongfa Xu
Pages: 3245-3251
Published online on: 23 March 2017

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Article

Overexpression of Tim-3 reduces Helicobacter pylori-associated inflammation through TLR4/NFκB signaling in vitro

Fucai Wang, Zhirong Mao, Dongsheng Liu, Jing Yu, Youhua Wang, Wen Ye, Dongjia Lin, Nanjin Zhou, Yong Xie
Pages: 3252-3258
Published online on: 21 March 2017

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Article

Tanshinone IIA increases protein expression levels of PERK, ATF6, IRE1α, CHOP, caspase‑3 and caspase‑12 in pancreatic cancer BxPC‑3 cell‑derived xenograft tumors

Tsung‑Lang Chiu, Chin Cheng Su
Pages: 3259-3263
Published online on: 22 March 2017

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Article

Role of tropomyosin in silkworm allergy

Kyoung Yong Jeong, In‑Soo Han, June Yong Lee, Kyung Hee Park, Jae‑Hyun Lee, Jung‑Won Park
Pages: 3264-3270
Published online on: 24 March 2017

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Article

miR‑217 inhibits osteogenic differentiation of rat bone marrow‑derived mesenchymal stem cells by binding to Runx2

Yu‑Long Zhu, Shui Wang, De‑Gang Ding, Liang Xu, Hai‑Tao Zhu
Pages: 3271-3277
Published online on: 22 March 2017

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Article

Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts

Jie Min, Bingshu Li, Cheng Liu, Wenjun Guo, Shasha Hong, Jianming Tang, Li Hong
Pages: 3278-3284
Published online on: 24 March 2017

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Article

Hepatitis B virus X protein increases microRNA‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway

Zhouhua Hou, Jun Quan
Pages: 3285-3291
Published online on: 23 March 2017

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Article

F221Y mutation in hepatitis B virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection

Huiming Li, Jian'an Jia, Mengmeng Wang, Hui Wang, Xing Gu, Meng Fang, Chunfang Gao
Pages: 3292-3300
Published online on: 23 March 2017

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Article

Chronological changes in the expression of phosphorylated tau and 5‑AMP‑activated protein kinase in the brain of senescence‑accelerated P8 mice

Hak‑Su Kim, Sohee Moon, Sujin Kim, Min‑Jae Lee, Min Hwa Suk, Dong‑Ho Park, Dong Wun Shin, Chang‑Shin Park, Ju‑Hee Kang
Pages: 3301-3309
Published online on: 23 March 2017

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Editorial

[Editorial] Environmental and occupational risk factors associated with different pathological conditions

Salvatore Santo Signorelli, Margherita Ferrante
Pages: 3315-3316
Published online on: 29 March 2017

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Article

New insights on ‘old’ toxicants in occupational toxicology (Review)

Chiara Costa, Edoardo Miozzi, Michele Teodoro, Giusi Briguglio, Venerando Rapisarda, Concettina Fenga
Pages: 3317-3322
Published online on: 24 March 2017

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Article Open Access

Health risk assessment of environmental selenium: Emerging evidence and challenges (Review)

Marco Vinceti, Tommaso Filippini, Silvia Cilloni, Annalisa Bargellini, Anna Valeria Vergoni, Aristides Tsatsakis, Margherita Ferrante
Pages: 3323-3335
Published online on: 24 March 2017

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Review Open Access

The risk of HCV infection among health-care workers and its association with extrahepatic manifestations (Review)

Adriana Garozzo, Luca Falzone, Venerando Rapisarda, Andrea Marconi, Diana Cinà, Concettina Fenga, Demetrios A. Spandidos, Massimo Libra
Pages: 3336-3339
Published online on: 24 March 2017

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Article

Determinants of serum manganese levels in an Italian population

Tommaso Filippini, Bernhard Michalke, Peter Grill, Carlotta Malagoli, Marcella Malavolti, Luciano Vescovi, Sabina Sieri, Vittorio Krogh, Andrea Cherubini, Giuseppe Maffeis, Roberto Lucchini, Margherita Ferrante, Marco Vinceti
Pages: 3340-3349
Published online on: 24 March 2017

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Article

Occupational exposure to Mount Etna's basaltic dust: Assessment of mutagenic and cytotoxic effects

Caterina Ledda, Salvatore Cocuzza, Monica Salerno, Paola Senia, Serena Matera, Venerando Rapisarda, Carla Loreto
Pages: 3350-3354
Published online on: 24 March 2017

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Review

Immunological effects of occupational exposure to lead (Review)

Concettina Fenga, Silvia Gangemi, Valentina Di Salvatore, Luca Falzone, Massimo Libra
Pages: 3355-3360
Published online on: 24 March 2017

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Article

Lead exposure and plasma mRNA expression in ERBB2 gene

Margherita Ferrante, Caterina Ledda, Gea Oliveri Conti, Maria Fiore, Venerando Rapisarda, Chiara Copat, Giuseppe Sole, Nivea Terzo, Salvatore Travali
Pages: 3361-3365
Published online on: 24 March 2017

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Review

Epigenetic alterations and occupational exposure to benzene, fibers, and heavy metals associated with tumor development (Review)

Rossella Salemi, Andrea Marconi, Valentina Di Salvatore, Sabrina Franco, Venerando Rapisarda, Massimo Libra
Pages: 3366-3371
Published online on: 24 March 2017

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Article

Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers

Caterina Ledda, Chiara Costa, Serena Matera, Beatrice Puglisi, Valentina Costanzo, Massimo Bracci, Concettina Fenga, Venerando Rapisarda, Carla Loreto
Pages: 3372-3378
Published online on: 24 March 2017

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Article

Absence of t(14;18) chromosome translocation in agricultural workers after short-term exposure to pesticides

Venerando Rapisarda, Caterina Ledda, Serena Matera, Lucrezia Fago, Giorgio Arrabito, Luca Falzone, Andrea Marconi, Massimo Libra, Carla Loreto
Pages: 3379-3382
Published online on: 24 March 2017

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Article

Iron and Parkinson's disease: A systematic review and meta-analysis

Giovanni Mostile, Calogero Edoardo Cicero, Loretta Giuliano, Mario Zappia, Alessandra Nicoletti
Pages: 3383-3389
Published online on: 24 March 2017

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Article

The effects of air pollutants on the mortality rate of lung cancer and leukemia

Mansooreh Dehghani, Laila Keshtgar, Mohammad Reza Javaheri, Zahra Derakhshan, Gea Oliveri Conti, Pietro Zuccarello, Margherita Ferrante
Pages: 3390-3397
Published online on: 24 March 2017

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Article Open Access

B(a)P adduct levels and fertility: A cross‑sectional study in a Sicilian population

Gea Oliveri Conti, Aldo Eugenio Calogero, Filippo Giacone, Maria Fiore, Martina Barchitta, Antonella Agodi, Margherita Ferrante
Pages: 3398-3404
Published online on: 27 March 2017

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Article

Toenail selenium as an indicator of environmental exposure: A cross-sectional study

Tommaso Filippini, Angela Ferrari, Bernhard Michalke, Peter Grill, Luciano Vescovi, Chiara Salvia, Carlotta Malagoli, Marcella Malavolti, Sabina Sieri, Vittorio Krogh, Annalisa Bargellini, Antonio Martino, Margherita Ferrante, Marco Vinceti
Pages: 3405-3412
Published online on: 24 March 2017

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Review

Kidney and heavy metals - The role of environmental exposure (Review)

Paolo Lentini, Luca Zanoli, Antonio Granata, Salvatore Santo Signorelli, Pietro Castellino, Roberto Dell'Aquila
Pages: 3413-3419
Published online on: 24 March 2017

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Article

Sclerostin is a possible candidate marker of arterial stiffness: Results from a cohort study in Catania

Agostino Gaudio, Valerio Fiore, Rosario Rapisarda, Maria Helga Sidoti, Anastasia Xourafa, Antonino Catalano, Giovanni Tringali, Luca Zanoli, Salvatore Santo Signorelli, Carmelo Erio Fiore
Pages: 3420-3424
Published online on: 24 March 2017

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Article

A systematic review of arterial stiffness, wave reflection and air pollution

Luca Zanoli, Paolo Lentini, Antonio Granata, Agostino Gaudio, Pasquale Fatuzzo, Leonardo Serafino, Stefania Rastelli, Valerio Fiore, Ambra D'Anca, Salvatore Santo Signorelli, Pietro Castellino
Pages: 3425-3429
Published online on: 24 March 2017

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Article

Heavy metal content and molecular species identification in canned tuna: Insights into human food safety

Anna Maria Pappalardo, Chiara Copat, Venera Ferrito, Alfina Grasso, Margherita Ferrante
Pages: 3430-3437
Published online on: 24 March 2017

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Article

Transition and heavy metals compared to oxidative parameter balance in patients with deep vein thrombosis: A case-control study

Margherita Ferrante, Maria Fiore, Gea Oliveri Conti, Valerio Fiore, Alfina Grasso, Chiara Copat, Salvatore Santo Signorelli
Pages: 3438-3444
Published online on: 24 March 2017

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Review

Deep vein thrombosis related to environment (Review)

Salvatore Santo Signorelli, Margherita Ferrante, Agostino Gaudio, Valerio Fiore
Pages: 3445-3448
Published online on: 24 March 2017

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CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
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Research progress on molecular therapy for glaucoma (Review)

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

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Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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