PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus

Nagata,Yuki; Bundo,Masahiko; Sugiura,Saiko; Kamita,Masahiro; Ono,Masaya; Hattori,Kotaro; Yoshida,Sumiko; Goto,Yu‑Ichi; Urakami,Katsuya; Niida,Shumpei

doi:10.3892/mmr.2017.7015

PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus

Authors:
- Yuki Nagata
- Masahiko Bundo
- Saiko Sugiura
- Masahiro Kamita
- Masaya Ono
- Kotaro Hattori
- Sumiko Yoshida
- Yu‑Ichi Goto
- Katsuya Urakami
- Shumpei Niida
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Affiliations: Medical Genome Center, National Center for Geriatrics and Gerontology, Aichi 474‑8511, Japan, Department of Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi 474‑8511, Japan, Department of Otolaryngology, National Center for Geriatrics and Gerontology, Obu, Aichi 474‑8511, Japan, Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Chuo‑ku, Tokyo 104‑0045, Japan, Medical Genome Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187‑8551, Japan, Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan
Published online on: July 15, 2017 https://doi.org/10.3892/mmr.2017.7015
Pages: 3034-3040
Copyright: © Nagata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is caused by the accumulation of cerebrospinal fluid (CSF) and is characterized by gait disturbance, urinary incontinence, and dementia. iNPH dementia is treatable by shunt operation; however, since the cognitive symptoms of iNPH are often similar to those of other dementias, including Alzheimer's disease (AD), accurate diagnosis of iNPH is difficult. To overcome this problem, the identification of novel diagnostic markers to distinguish iNPH and AD is warranted. Using comparative proteomic analysis of CSF from patients with iNPH and AD, protein tyrosine phosphatase receptor type Q (PTPRQ) was identified as a candidate biomarker protein for discriminating iNPH from AD. ELISA analysis indicated that the PTPRQ concentration in the CSF was significantly higher in patients with iNPH compared with those with AD. In addition, the PTPRQ concentration in the CSF of non‑responders to shunt operation (SNRs) tended to be relatively lower compared with that in the responders. PTPRQ may be a useful biomarker for discriminating between patients with iNPH and AD, and may be a potential companion biomarker to identify SNRs among patients with iNPH. Additional large‑scale analysis may aid in understanding the novel aspects of iNPH.

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