Open Access

Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance

  • Authors:
    • Hua Ding
    • Zhi‑Hua Ye
    • Dong‑Yue Wen
    • Xiao‑Liang Huang
    • Chu‑Mei Zeng
    • Jie Mo
    • Yi‑Qiang Jiang
    • Jian‑Jun Li
    • Xiao‑Yong Cai
    • Hong Yang
    • Gang Chen
  • View Affiliations

  • Published online on: August 17, 2017     https://doi.org/10.3892/mmr.2017.7275
  • Pages: 5393-5405
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The clinical significance of microRNA (miR)‑136‑5p in hepatocellular carcinoma (HCC) has not been verified. Therefore, in the current study, the authors aimed to explore miR‑136‑5p expression and its clinical significance in HCC, as well as to investigate its potential target genes function. The authors detected the levels of miR‑136‑5p in 101 pairs of HCC and para‑cancer tissues via reverse transcription‑quantitative polymerase chain reaction. Gene Expression Omnibus database and the Cancer Genome Atlas (TCGA) database were used to further verify the clinical significance of miR‑136‑5p expression in HCC. The target genes prediction analysis of miR‑136‑5p, natural language processing (NLP) analysis of HCC in PubMed and gene functional enrichment analysis were conducted. The miR‑136‑5p level was markedly downregulated in HCC tissue, compared to para‑non‑tumor tissue. MiR‑136‑5p expression decreased in HCC patients with metastasis (P=0.004), advance TNM stage (P<0.001), portal vein tumor embolus (P=0.007) and vaso‑invasion (P=0.003), compared with those HCC patients with non‑metastasis, early TNM stage, non‑portal vein tumor embolus and non‑vaso‑invasion, respectively. In the TCGA database, downregulated miR‑136‑5p was also observed in HCC tissue compared to normal liver tissue (P<0.001). There were 178 genes obtained from the overlap between predicted targets and NLP analysis. GO and KEGG pathway analyses revealed some significant pathways related to cancers. Downregulation of miR‑136‑5p may be responsible for the carcinogenesis and aggressiveness of HCC. miR‑136‑5p may act as an anti‑carcinoma miRNA, which is essential for HCC progression through the regulation of various signaling pathways. Thus, miR‑136‑5p interaction may provide a novel strategy for HCC treatment.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ding H, Ye ZH, Wen DY, Huang XL, Zeng CM, Mo J, Jiang YQ, Li JJ, Cai XY, Yang H, Yang H, et al: Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance. Mol Med Rep 16: 5393-5405, 2017
APA
Ding, H., Ye, Z., Wen, D., Huang, X., Zeng, C., Mo, J. ... Chen, G. (2017). Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance. Molecular Medicine Reports, 16, 5393-5405. https://doi.org/10.3892/mmr.2017.7275
MLA
Ding, H., Ye, Z., Wen, D., Huang, X., Zeng, C., Mo, J., Jiang, Y., Li, J., Cai, X., Yang, H., Chen, G."Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance". Molecular Medicine Reports 16.4 (2017): 5393-5405.
Chicago
Ding, H., Ye, Z., Wen, D., Huang, X., Zeng, C., Mo, J., Jiang, Y., Li, J., Cai, X., Yang, H., Chen, G."Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance". Molecular Medicine Reports 16, no. 4 (2017): 5393-5405. https://doi.org/10.3892/mmr.2017.7275