Open Access

MicroRNA‑497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3

Retraction in: /10.3892/mmr.2022.12843

  • Authors:
    • Juhua Zhuang
    • Ying Ye
    • Guoyu Wang
    • Jing Ni
    • Saifei He
    • Cuihua Hu
    • Wei Xia
    • Zhongwei Lv
  • View Affiliations

  • Published online on: August 24, 2017     https://doi.org/10.3892/mmr.2017.7345
  • Pages: 5815-5822
  • Copyright: © Zhuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thyroid cancer is the most common tumor of the endocrine organs. Emerging studies have indicated the critical roles of microRNAs (miRs) in papillary thyroid cancer (PTC) formation and progression through function as tumor suppressors or oncogenes. The present study investigated the expression level and biological roles of miR‑497 in PTC and its underlying mechanisms. It was demonstrated that the expression level of miR‑497 was reduced in both PTC tissues and cell lines. Enforced expression of miR‑497 suppressed PTC cell proliferation, migration and invasion. According to bioinformatics analysis, a luciferase reporter assay, reverse transcription‑quantitative polymerase chain reaction and western blotting, RAC‑γ serine/threonine‑protein kinase (AKT3) was demonstrated to be the direct target gene of miR‑497. In addition, AKT3 expression increased in PTC tissues and negatively correlated with miR‑497 expression. Furthermore, downregulation of AKT3 also suppressed cell proliferation, migration and invasion of PTC, which had similar roles to miR‑497 overexpression in PTC cells. Taken together, these results suggested that this newly identified miR‑497/AKT3 signaling pathway may contribute to PTC occurrence and progression. These findings provide novel potential therapeutic targets for the therapy of PTC.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhuang J, Ye Y, Wang G, Ni J, He S, Hu C, Xia W and Lv Z: MicroRNA‑497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3 Retraction in /10.3892/mmr.2022.12843. Mol Med Rep 16: 5815-5822, 2017
APA
Zhuang, J., Ye, Y., Wang, G., Ni, J., He, S., Hu, C. ... Lv, Z. (2017). MicroRNA‑497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3 Retraction in /10.3892/mmr.2022.12843. Molecular Medicine Reports, 16, 5815-5822. https://doi.org/10.3892/mmr.2017.7345
MLA
Zhuang, J., Ye, Y., Wang, G., Ni, J., He, S., Hu, C., Xia, W., Lv, Z."MicroRNA‑497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3 Retraction in /10.3892/mmr.2022.12843". Molecular Medicine Reports 16.5 (2017): 5815-5822.
Chicago
Zhuang, J., Ye, Y., Wang, G., Ni, J., He, S., Hu, C., Xia, W., Lv, Z."MicroRNA‑497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3 Retraction in /10.3892/mmr.2022.12843". Molecular Medicine Reports 16, no. 5 (2017): 5815-5822. https://doi.org/10.3892/mmr.2017.7345