Association between endothelin‑1 and fibromyalgia syndrome

  • Authors:
    • Seong‑Su Nah
    • Hwayoung Lee
    • Yeongseon Hong
    • Jiyun Im
    • Hansol Won
    • Sung‑Hae Chang
    • Hyung‑Ki Kim
    • Jun‑Tack Kwon
    • Hak‑Jae Kim
  • View Affiliations

  • Published online on: August 29, 2017     https://doi.org/10.3892/mmr.2017.7395
  • Pages: 6234-6239
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Abstract

Fibromyalgia syndrome (FMS) is characterized by widespread chronic musculoskeletal pain, stiffness and pressure hyperalgesia at soft tissue tender points. Patients with FMS may exhibit a tendency towards cold extremities and cold‑induced vasospasm. Endothelin‑1 (EDN1) is a potent vasoconstrictor that is mainly produced by endothelial cells. The present study aimed to determine whether plasma expression levels avvnd single‑nucleotide polymorphism (SNP; rs1800541) of the EDN1 gene were associated with FMS and/or any of its clinical variables. Plasma EDN1 levels were assessed by ELISA, and SNP genotypes were determined using polymerase chain reaction‑high‑resolution melting curve analysis. Patients with the TG genotype and the G allele may have an elevated risk of FMS. In addition, patients with FMS with the TG genotype and/or T allele exhibited higher plasma EDN1 levels compared with healthy controls. EDN1 levels increased significantly in patients with FMS compared with normal controls. In addition, EDN1 SNP was found to be associated with susceptibility to FMS.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Nah SS, Lee H, Hong Y, Im J, Won H, Chang SH, Kim HK, Kwon JT and Kim HJ: Association between endothelin‑1 and fibromyalgia syndrome. Mol Med Rep 16: 6234-6239, 2017
APA
Nah, S., Lee, H., Hong, Y., Im, J., Won, H., Chang, S. ... Kim, H. (2017). Association between endothelin‑1 and fibromyalgia syndrome. Molecular Medicine Reports, 16, 6234-6239. https://doi.org/10.3892/mmr.2017.7395
MLA
Nah, S., Lee, H., Hong, Y., Im, J., Won, H., Chang, S., Kim, H., Kwon, J., Kim, H."Association between endothelin‑1 and fibromyalgia syndrome". Molecular Medicine Reports 16.5 (2017): 6234-6239.
Chicago
Nah, S., Lee, H., Hong, Y., Im, J., Won, H., Chang, S., Kim, H., Kwon, J., Kim, H."Association between endothelin‑1 and fibromyalgia syndrome". Molecular Medicine Reports 16, no. 5 (2017): 6234-6239. https://doi.org/10.3892/mmr.2017.7395