Taurine‑upregulated gene 1: A vital long non‑coding RNA associated with cancer in humans (Review)

  • Authors:
    • Wen‑Yu Wang
    • Yan‑Fen Wang
    • Pei Ma
    • Tong‑Peng Xu
    • Yong‑Qian Shu
  • View Affiliations

  • Published online on: September 12, 2017     https://doi.org/10.3892/mmr.2017.7472
  • Pages: 6467-6471
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Abstract

It is widely reported that long non‑coding RNAs (lncRNAs) are involved in regulating cell differentiation, proliferation, apoptosis and other biological processes. Certain lncRNAs have been found to be crucial in various types of tumor. Taurine‑upregulated gene 1 (TUG1) has been shown to be expressed in a tissue‑specific pattern and exert oncogenic or tumor suppressive functions in different types of cancer in humans. According to previous studies, TUG1 is predominantly located in the nucleus and may regulate gene expression at the transcriptional level. It mediates chromosomal remodeling and coordinates with polycomb repressive complex 2 (PRC2) to regulate gene expression. Although the mechanisms of how TUG1 affects the tumor genesis process remain to be fully elucidated, increasing studies have suggested that TUG1 offers potential as a diagnostic and prognostic biomarker, and as a therapeutic target in certain types of tumor. This review aims to summarize current evidence concerning the characteristics, mechanisms and associations with cancer of TUG1.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang WY, Wang YF, Ma P, Xu TP and Shu YQ: Taurine‑upregulated gene 1: A vital long non‑coding RNA associated with cancer in humans (Review). Mol Med Rep 16: 6467-6471, 2017
APA
Wang, W., Wang, Y., Ma, P., Xu, T., & Shu, Y. (2017). Taurine‑upregulated gene 1: A vital long non‑coding RNA associated with cancer in humans (Review). Molecular Medicine Reports, 16, 6467-6471. https://doi.org/10.3892/mmr.2017.7472
MLA
Wang, W., Wang, Y., Ma, P., Xu, T., Shu, Y."Taurine‑upregulated gene 1: A vital long non‑coding RNA associated with cancer in humans (Review)". Molecular Medicine Reports 16.5 (2017): 6467-6471.
Chicago
Wang, W., Wang, Y., Ma, P., Xu, T., Shu, Y."Taurine‑upregulated gene 1: A vital long non‑coding RNA associated with cancer in humans (Review)". Molecular Medicine Reports 16, no. 5 (2017): 6467-6471. https://doi.org/10.3892/mmr.2017.7472