Open Access

PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review)

  • Authors:
    • Hua‑Zhong Ying
    • Qin Chen
    • Wen‑You Zhang
    • Huan‑Huan Zhang
    • Yue Ma
    • Song‑Zhao Zhang
    • Jie Fang
    • Chen‑Huan Yu
  • View Affiliations

  • Published online on: September 27, 2017     https://doi.org/10.3892/mmr.2017.7641
  • Pages:7879-7889
  • Copyright: © Ying et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The platelet‑derived growth factor (PDFG) signaling pathway exerts persistent activation in response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this pathway modulates a broad spectrum of cellular processes, including cell growth, differentiation, inflammation and carcinogenesis, it has emerged as a therapeutic target for hepatic fibrosis and liver‑associated disorders. The present review exhibits the current knowledge of the role of the PDGF signaling pathway and its pathological profiles in hepatic fibrosis, and assesses the potential of inhibitors which have been investigated in the experimental hepatic fibrosis model, in addition to the clinical challenges associated with these inhibitors.

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Journal Cover

December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

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Copy and paste a formatted citation
APA
Ying, H., Chen, Q., Zhang, W., Zhang, H., Ma, Y., Zhang, S. ... Yu, C. (2017). PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review). Molecular Medicine Reports, 16, 7879-7889. https://doi.org/10.3892/mmr.2017.7641
MLA
Ying, H., Chen, Q., Zhang, W., Zhang, H., Ma, Y., Zhang, S., Fang, J., Yu, C."PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review)". Molecular Medicine Reports 16.6 (2017): 7879-7889.
Chicago
Ying, H., Chen, Q., Zhang, W., Zhang, H., Ma, Y., Zhang, S., Fang, J., Yu, C."PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review)". Molecular Medicine Reports 16, no. 6 (2017): 7879-7889. https://doi.org/10.3892/mmr.2017.7641