Open Access

Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment

  • Authors:
    • Lili Gao
    • Zhihong Jiang
    • Zhaocheng Cai
    • Ming Cai
    • Qing Zhang
    • Yingying Ma
    • Guoliang Li
    • Fengzhu Zhao
    • Qiang Ma
  • View Affiliations

  • Published online on: September 29, 2017     https://doi.org/10.3892/mmr.2017.7668
  • Pages:8209-8215
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampus (HP), substantia nigra, red nucleus (RN), dentate nucleus (DN), caudate nucleus (CN), globus pallidus (GP), putamen (PUT), frontal white matter, temporal cortex (TC), and parietal cortex. Body iron indices, including serum iron, serum transferrin, ferritin and total iron binding capacity, were measured. Phase values of the left (L)‑DN, L‑CN, and bilateral PUT in the MCI group were significantly lower compared with NC group. Phase values of the right (R)‑RN, bilateral DN, and bilateral PUT in the AD group were significantly lower compared with the MCI group. Phase values of the bilateral HP, DN, RN, CN, GP, PUT, and L‑TC in the AD group were significantly lower compared with the NC group. Serum ferritin levels in the MCI and AD groups were significantly lower compared with the NC group. Only serum iron in the AD group was positively associated with iron content in the R‑HP. Brain iron deposition and body iron levels both increased in MCI and AD patients, however, excessive brain iron accumulation may have no association with body iron level. SWI was particularly effective at recognizing the presence of brain iron in the MCI and AD groups.

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December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
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APA
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y. ... Ma, Q. (2017). Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment. Molecular Medicine Reports, 16, 8209-8215. https://doi.org/10.3892/mmr.2017.7668
MLA
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y., Li, G., Zhao, F., Ma, Q."Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment". Molecular Medicine Reports 16.6 (2017): 8209-8215.
Chicago
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y., Li, G., Zhao, F., Ma, Q."Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment". Molecular Medicine Reports 16, no. 6 (2017): 8209-8215. https://doi.org/10.3892/mmr.2017.7668