SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells

  • Authors:
    • Kang Min Lee
    • Kangwook Lee
    • Youn Kyung Choi
    • Yu‑Jeong Choi
    • Hye‑Sook Seo
    • Seong‑Gyu Ko
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/mmr.2017.7597
  • Pages:8237-8244
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Abstract

Cervical cancer is a prevalent disease that may lead to mortality in women. In spite of the development of common therapeutic agents to treat cancer, there are several limitations of their use owing to side effects and drug resistance, which may induce cancer recurrence. The anticancer effects of the new herbal mixture SH003 (comprising Astragalus membranaceus, Angelica gigas and Trichosanthes kirilowii Maximowicz) have been examined in various types of cancer. Thus, the present study hypothesized that SH003 may be an effective treatment for cervical cancer. SH003 treatment inhibited the growth of HeLa cells, whereas it did not affect the growth of rat intestinal epithelial cells. In addition, SH003 treatment increased the expression of apoptosis‑related proteins and promoted apoptotic cell death in HeLa cells. SH003 treatment also led to G1 phase arrest in HeLa cells. Furthermore, SH003 treatment induced the production of reactive oxygen species (ROS); however, ROS production did not appear to be related to SH003‑mediated apoptosis. Results from the present study indicated that the SH003‑induced inhibition of HeLa cell growth may be mediated through G1 phase arrest and extrinsic apoptosis, suggested that SH003 may be a potential treatment for cervical cancer.

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December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
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APA
Lee, K.M., Lee, K., Choi, Y.K., Choi, Y., Seo, H., & Ko, S. (2017). SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Molecular Medicine Reports, 16, 8237-8244. https://doi.org/10.3892/mmr.2017.7597
MLA
Lee, K. M., Lee, K., Choi, Y. K., Choi, Y., Seo, H., Ko, S."SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells". Molecular Medicine Reports 16.6 (2017): 8237-8244.
Chicago
Lee, K. M., Lee, K., Choi, Y. K., Choi, Y., Seo, H., Ko, S."SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells". Molecular Medicine Reports 16, no. 6 (2017): 8237-8244. https://doi.org/10.3892/mmr.2017.7597