1
|
Bernal W, Auzinger G, Dhawan A and Wendon
J: Acute liver failure. Lancet. 376:190–201. 2010. View Article : Google Scholar : PubMed/NCBI
|
2
|
Zhang A, Sun H and Wang X: Recent advances
in natural products from plants for treatment of liver diseases.
Eur J Med Chem. 63:570–577. 2013. View Article : Google Scholar : PubMed/NCBI
|
3
|
Paterson I and Anderson EA: Chemistry. The
renaissance of natural products as drug candidates. Science.
310:451–453. 2005. View Article : Google Scholar : PubMed/NCBI
|
4
|
Girish C and Pradhan SC: Drug development
for liver diseases: Focus on picroliv, ellagic acid and curcumin.
Fundam Clin Pharmacol. 22:623–632. 2008. View Article : Google Scholar : PubMed/NCBI
|
5
|
Li C, Lin G and Zuo Z: Pharmacological
effects and pharmacokinetics properties of Radix Scutellariae and
its bioactive flavones. Biopharm Drug Dispos. 32:427–445. 2011.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Jang EJ, Cha SM, Choi SM and Cha JD:
Combination effects of baicalein with antibiotics against oral
pathogens. Arch Oral Biol. 59:1233–1241. 2014. View Article : Google Scholar : PubMed/NCBI
|
7
|
Choi JH, Choi AY, Yoon H, Choe W, Yoon KS,
Ha J, Yeo EJ and Kang I: Baicalein protects HT22 murine hippocampal
neuronal cells against endoplasmic reticulum stress-induced
apoptosis through inhibition of reactive oxygen species production
and CHOP induction. Exp Mol Med. 42:811–822. 2010. View Article : Google Scholar : PubMed/NCBI
|
8
|
Cui G, Luk SC, Li RA, Chan KK, Lei SW,
Wang L, Shen H, Leung GP and Lee SM: Cytoprotection of baicalein
against oxidative stress-induced cardiomyocytes injury through the
Nrf2/Keap1 pathway. J Cardiovasc Pharmacol. 65:39–46. 2015.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Kong EK, Yu S, Sanderson JE, Chen KB,
Huang Y and Yu CM: A novel anti-fibrotic agent, baicalein, for the
treatment of myocardial fibrosis in spontaneously hypertensive
rats. Eur J Pharmacol. 658:175–181. 2011. View Article : Google Scholar : PubMed/NCBI
|
10
|
Gao L, Li C, Yang RY, Lian WW, Fang JS,
Pang XC, Qin XM, Liu AL and Du GH: Ameliorative effects of
baicalein in MPTP-induced mouse model of Parkinson's disease: A
microarray study. Pharmacol Biochem Behav. 133:155–163. 2015.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Chen K, Zhang S, Ji Y, Li J, An P, Ren H,
Liang R, Yang J and Li Z: Baicalein inhibits the invasion and
metastatic capabilities of hepatocellular carcinoma cells via
down-regulation of the ERK pathway. PLoS One. 8:e729272013.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Liu A, Huang L, Fan H, Fang H, Yang Y, Liu
S, Hu J, Hu Q, Dirsch O and Dahmen U: Baicalein pretreatment
protects against liver ischemia/reperfusion injury via inhibition
of NF-kB pathway in mice. Int Immunopharmacol. 24:72–79. 2015.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Liu A, Wang W, Fang H, Yang Y, Jiang X,
Liu S, Hu J, Hu Q, Dahmen U and Dirsch O: Baicalein protects
against polymicrobial sepsis-induced liver injury via inhibition of
inflammation and apoptosis in mice. Eur J Pharmacol. 748:45–53.
2015. View Article : Google Scholar : PubMed/NCBI
|
14
|
Zhang Y, Shan L, Hua Y, Wang D, Zeng H,
Liu R, Zhang W and Hu Z: Baicalein selectively induces apoptosis in
activated lymphocytes and ameliorates concanavalin a-induced
hepatitis in mice. PLoS One. 8:e695922013. View Article : Google Scholar : PubMed/NCBI
|
15
|
Sun H, Che QM, Zhao X and Pu XP:
Antifibrotic effects of chronic baicalein administration in a CCl4
liver fibrosis model in rats. Eur J Pharmacol. 631:53–60. 2010.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Jaeschke H, McGill MR and Ramachandran A:
Oxidant stress, mitochondria, and cell death mechanisms in
drug-induced liver injury: Lessons learned from acetaminophen
hepatotoxicity. Drug Metab Rev. 44:88–106. 2012. View Article : Google Scholar : PubMed/NCBI
|
17
|
Kohen R and Nyska A: Oxidation of
biological systems: Oxidative stress phenomena, antioxidants, redox
reactions, and methods of their quantification. Toxicol Pathol.
30:620–650. 2002. View Article : Google Scholar : PubMed/NCBI
|
18
|
Joyeux M, Rolland A, Fleurentin J, Mortier
F and Dorfman P: tert-Butyl hydroperoxide-induced injury in
isolated rat hepatocytes: A model for studying anti-hepatotoxic
crude drugs. Planta Med. 56:171–174. 1990. View Article : Google Scholar : PubMed/NCBI
|
19
|
Shen CH, Tung SY, Huang WS, Lu CC, Lee KC,
Hsieh YY, Chang PJ, Liang HF, Chen JH, Lin TH, et al: Exploring the
effects of tert-butylhydroperoxide induced liver injury using
proteomic approach. Toxicology. 316:61–70. 2014. View Article : Google Scholar : PubMed/NCBI
|
20
|
Wang K: Autophagy and apoptosis in liver
injury. Cell Cycle. 14:1631–1642. 2015. View Article : Google Scholar : PubMed/NCBI
|
21
|
Mizushima N, Levine B, Cuervo AM and
Klionsky DJ: Autophagy fights disease through cellular
self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI
|
22
|
Chen S, Dobrovolsky VN, Liu F, Wu Y, Zhang
Z, Mei N and Guo L: The role of autophagy in usnic acid-induced
toxicity in hepatic cells. Toxicol Sci. 142:33–44. 2014. View Article : Google Scholar : PubMed/NCBI
|
23
|
Sun Q, Gao W, Loughran P, Shapiro R, Fan
J, Billiar TR and Scott MJ: Caspase 1 activation is protective
against hepatocyte cell death by up-regulating beclin 1 protein and
mitochondrial autophagy in the setting of redox stress. J Biol
Chem. 288:15947–15958. 2013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Wang YF, Li T, Tang ZH, Chang LL, Zhu H,
Chen XP, Wang YT and Lu JJ: Baicalein triggers autophagy and
inhibits the protein kinase B/Mammalian target of rapamycin pathway
in hepatocellular carcinoma HepG2 cells. Phytother Res. 29:674–679.
2015. View
Article : Google Scholar : PubMed/NCBI
|
25
|
Chen L, Zhang F, Kong D, Zhu X, Chen W,
Wang A and Zheng S: Saikosaponin D disrupts platelet-derived growth
factor-β receptor/p38 pathway leading to mitochondrial apoptosis in
human LO2 hepatocyte cells: A potential mechanism of
hepatotoxicity. Chem Biol Interact. 206:76–82. 2013. View Article : Google Scholar : PubMed/NCBI
|
26
|
Yan X, Jiang Z, Bi L, Yang Y and Chen W:
Salvianolic acid A attenuates TNF-α-and d-GalN-induced ER
stress-mediated and mitochondrial-dependent apoptosis by modulating
Bax/Bcl-2 ratio and calcium release in hepatocyte LO2 cells. Naunyn
Schmiedebergs Arch Pharmacol. 388:817–830. 2015. View Article : Google Scholar : PubMed/NCBI
|
27
|
Cossarizza A, Baccarani-Contri M,
Kalashnikova G and Franceschi C: A new method for the
cytofluorometric analysis of mitochondrial membrane potential using
the J-aggregate forming lipophilic cation
5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine
iodide (JC-1). Biochem Biophys Res Commun. 197:40–45. 1993.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Woźniak D, Dryś A and Matkowski A:
Antiradical and antioxidant activity of flavones from Scutellariae
baicalensis radix. Nat Prod Res. 29:1567–1570. 2015. View Article : Google Scholar : PubMed/NCBI
|
29
|
He J, Yu JJ, Xu Q, Wang L, Zheng JZ, Liu
LZ and Jiang BH: Downregulation of ATG14 by EGR1-MIR152 sensitizes
ovarian cancer cells to cisplatin-induced apoptosis by inhibiting
cyto-protective autophagy. Autophagy. 11:373–384. 2015. View Article : Google Scholar : PubMed/NCBI
|
30
|
Kimura T, Takabatake Y, Takahashi A and
Isaka Y: Chloroquine in cancer therapy: A double-edged sword of
autophagy. Cancer Res. 73:3–7. 2013. View Article : Google Scholar : PubMed/NCBI
|
31
|
Jung CH, Ro SH, Cao J, Otto NM and Kim DH:
mTOR regulation of autophagy. FEBS Lett. 584:1287–1295. 2010.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Fan GW, Zhang Y, Jiang X, Zhu Y, Wang B,
Su L, Cao W, Zhang H and Gao X: Anti-inflammatory activity of
baicalein in LPS-stimulated RAW264.7 macrophages via estrogen
receptor and NF-kB-dependent pathways. Inflammation. 36:1584–1591.
2013. View Article : Google Scholar : PubMed/NCBI
|
33
|
Gao Z, Huang K and Xu H: Protective
effects of flavonoids in the roots of Scutellaria baicalensis
Georgi against hydrogen peroxide-induced oxidative stress in
HS-SY5Y cells. Pharmacol Res. 43:173–178. 2001. View Article : Google Scholar : PubMed/NCBI
|
34
|
Ohtake N, Nakai Y, Yamamoto M, Sakakibara
I, Takeda S, Amagaya S and Aburada M: Separation and isolation
methods for analysis of the active principles of Sho-saiko-to (SST)
oriental medicine. J Chromatogr B Analyt Technol Biomed Life Sci.
812:135–148. 2004. View Article : Google Scholar : PubMed/NCBI
|
35
|
Hirayama C, Okumura M, Tanikawa K, Yano M,
Mizuta M and Ogawa N: A multicenter randomized controlled clinical
trial of Shosaiko-to in chronic active hepatitis. Gastroenterol
Jpn. 24:715–719. 1989.PubMed/NCBI
|
36
|
Oka H, Yamamoto S, Kuroki T, Harihara S,
Marumo T, Kim SR, Monna T, Kobayashi K and Tango T: Prospective
study of chemoprevention of hepatocellular carcinoma with
Sho-saiko-to (TJ-9). Cancer. 76:743–749. 1995. View Article : Google Scholar : PubMed/NCBI
|
37
|
Wu YL, Lian LH, Wan Y and Nan JX:
Baicalein inhibits nuclear factor-kB and apoptosis via c-FLIP and
MAPK in D-GalN/LPS induced acute liver failure in murine models.
Chem Biol Interact. 188:526–534. 2010. View Article : Google Scholar : PubMed/NCBI
|
38
|
Chen HM, Hsu JH, Liou SF, Chen TJ, Chen
LY, Chiu CC and Yeh JL: Baicalein, an active component of
Scutellaria baicalensis Georgi, prevents
lysophosphatidylcholine-induced cardiac injury by reducing reactive
oxygen species production, calcium overload and apoptosis via MAPK
pathways. BMC Complement Altern Med. 14:2332014. View Article : Google Scholar : PubMed/NCBI
|
39
|
Vidyashankar S, K Mitra S and Nandakumar
KS: Liv.52 protects HepG2 cells from oxidative damage induced by
tert-butyl hydroperoxide. Mol Cell Biochem. 333:41–48. 2010.
View Article : Google Scholar : PubMed/NCBI
|
40
|
Simon HU, Haj-Yehia A and Levi-Schaffer F:
Role of reactive oxygen species (ROS) in apoptosis induction.
Apoptosis. 5:415–418. 2000. View Article : Google Scholar : PubMed/NCBI
|
41
|
Rautou PE, Mansouri A, Lebrec D, Durand F,
Valla D and Moreau R: Autophagy in liver diseases. J Hepatol.
53:1123–1134. 2010. View Article : Google Scholar : PubMed/NCBI
|
42
|
Yin XM, Ding WX and Gao W: Autophagy in
the liver. Hepatology. 47:1773–1785. 2008. View Article : Google Scholar : PubMed/NCBI
|
43
|
Park M, Kim YH, Woo SY, Lee HJ, Yu Y, Kim
HS, Park YS, Jo I, Park JW, Jung SC, et al: Tonsil-derived
mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in
mice via autophagy activation. Sci Rep. 5:86162015. View Article : Google Scholar : PubMed/NCBI
|
44
|
Yang X, Wang J, Dai J, Shao J, Ma J, Chen
C, Ma S, He Q, Luo P and Yang B: Autophagy protects against
dasatinib-induced hepatotoxicity via p38 signaling. Oncotarget.
6:6203–6217. 2015. View Article : Google Scholar : PubMed/NCBI
|
45
|
Lin CW, Zhang H, Li M, Xiong X, Chen X,
Chen X, Dong XC and Yin XM: Pharmacological promotion of autophagy
alleviates steatosis and injury in alcoholic and non-alcoholic
fatty liver conditions in mice. J Hepatol. 58:993–999. 2013.
View Article : Google Scholar : PubMed/NCBI
|