Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B

  • Authors:
    • Dongsheng Wang
    • Qin Du
    • Guangcheng Luo
    • Qiang Wang
    • Guangrong Wang
    • Guoyuan Zhang
    • Zhengwei Leng
    • Xiaolan Guo
  • View Affiliations

  • Published online on: September 26, 2017     https://doi.org/10.3892/mmr.2017.7630
  • Pages:8556-8562
Metrics: PDF 0 views | HTML 0 views
0

Abstract

Previous studies demonstrated that immune dysregulation is an important cause of hepatitis B virus (HBV)‑mediated liver damage. Co‑stimulators including programmed cell death protein 1 (PD‑1) and inducible T cell co‑stimulator (ICOS) are involved in the pathogenesis of HBV. In the present study, the serum levels of soluble (s)PD‑1 and sICOS in patients with chronic HBV infections, were investigated, and the association between sPD‑1 and sICOS levels and liver injury degree was investigated. Serum sPD‑1 and sICOS levels were increased in the HBV‑patient group particularly in the HBV external core antigen positive group. In the immune clearance group, sPD‑1 and sICOS were increased compared with the tolerance group. Furthermore, the relative mRNA expression levels were also increased in patients with HBV. However there was no correlation between sPD‑1 and sICOS levels and HBV antibodies or PD‑1/ICOS mRNA copies. The altered sPD‑1 and sICOS serum levels in the different HBV groups may reflect the dysregulation of T cell activation, and may be associated with the HBV pathological process.

Related Articles

Journal Cover

December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G. ... Guo, X. (2017). Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B. Molecular Medicine Reports, 16, 8556-8562. https://doi.org/10.3892/mmr.2017.7630
MLA
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G., Leng, Z., Guo, X."Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B". Molecular Medicine Reports 16.6 (2017): 8556-8562.
Chicago
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G., Leng, Z., Guo, X."Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B". Molecular Medicine Reports 16, no. 6 (2017): 8556-8562. https://doi.org/10.3892/mmr.2017.7630