Open Access

Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer

  • Authors:
    • Liang Chen
    • Lushun Yuan
    • Gang Wang
    • Rui Cao
    • Jianping Peng
    • Bo Shu
    • Guofeng Qian
    • Xinghuan Wang
    • Yu Xiao
  • View Affiliations

  • Published online on: October 4, 2017     https://doi.org/10.3892/mmr.2017.7726
  • Pages:8709-8720
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Accumulated evidence has indicated that micro (mi)RNAs play vital roles in the occurrence and development of human muscle invasive bladder cancer (MIBC), however, little is known about the miRNAs' regulatory networks. In the present study, the authors aimed to use bioinformatics analysis to identify the key miRNAs and potential target genes, as well as studying the underlying mechanisms for MIBC. They collected several human MIBC tissues to generate a miRNA expression analysis by microarray analysis comparing with normal bladder tissues, identifying 104 differentially expressed miRNAs (102 were downregulated and 2 were upregulated) and predicted 11,884 putative target genes of the dysregulated miRNAs. To understand the function of dysregulated miRNAs in the development of MIBC, networks among miRNAs and genes, gene ontologies and pathways were built. The subsequent bioinformatics analysis indicated that the mitogen‑associated protein kinase (MAPK) signaling pathway, apoptosis and pathways in cancer and the cell cycle, were significantly enriched Overall, these results provided comprehensive information on the biological function of dysregulated miRNAs in the development of MIBC. The identification of miRNAs and their putative targets may offer new diagnostic and therapeutic strategies for human muscle invasive bladder cancer.

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December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
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APA
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B. ... Xiao, Y. (2017). Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer. Molecular Medicine Reports, 16, 8709-8720. https://doi.org/10.3892/mmr.2017.7726
MLA
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B., Qian, G., Wang, X., Xiao, Y."Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer". Molecular Medicine Reports 16.6 (2017): 8709-8720.
Chicago
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B., Qian, G., Wang, X., Xiao, Y."Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer". Molecular Medicine Reports 16, no. 6 (2017): 8709-8720. https://doi.org/10.3892/mmr.2017.7726