IL‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer

  • Authors:
    • Yidi Guo
    • Ying Zang
    • Lianzheng Lv
    • Feng Cai
    • Tingting Qian
    • Guoying Zhang
    • Quancheng Feng
  • View Affiliations

  • Published online on: October 10, 2017     https://doi.org/10.3892/mmr.2017.7747
  • Pages:9035-9042
0

Abstract

Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, and is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action of IL‑8 regarding the ability to promote proliferation and to inhibit apoptosis in prostate cancer. Here, the aim of the present study was to investigate the effects of IL‑8 on the prostate cancer cell line and determine possible mechanisms underlying its effect. In this study, IL‑8 was shown to be significantly upregulated in prostate cancer compared with paired normal control tissues. The data showed that IL‑8 exhibits direct oncogenicity, which significantly induced cell proliferation, invasion and attenuated apoptosis in prostate cancer cells via signal transducer and activator of transcription 3/protein kinase B/nuclear factor‑κB signaling pathways. In conclusion, modulation of IL‑8 expression or its associated signaling pathway may provide a novel working mechanism of IL‑8 in prostate cancer, and a promising strategy for controlling the progression and metastasis of prostate cancer.

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Journal Cover

December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

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APA
Guo, Y., Zang, Y., Lv, L., Cai, F., Qian, T., Zhang, G., & Feng, Q. (2017). IL‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer. Molecular Medicine Reports, 16, 9035-9042. https://doi.org/10.3892/mmr.2017.7747
MLA
Guo, Y., Zang, Y., Lv, L., Cai, F., Qian, T., Zhang, G., Feng, Q."IL‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer". Molecular Medicine Reports 16.6 (2017): 9035-9042.
Chicago
Guo, Y., Zang, Y., Lv, L., Cai, F., Qian, T., Zhang, G., Feng, Q."IL‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer". Molecular Medicine Reports 16, no. 6 (2017): 9035-9042. https://doi.org/10.3892/mmr.2017.7747