Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia

  • Authors:
    • Fengmei Tan
    • Wenbin Dong
    • Xiaoping Lei
    • Xingling Liu
    • Qingping Li
    • Lan Kang
    • Shuai Zhao
    • Chan Zhang
  • View Affiliations

  • Published online on: November 8, 2017     https://doi.org/10.3892/mmr.2017.8012
  • Pages: 1283-1288
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Abstract

A prospective study was performed to investigate the effects of hyperoxia on the expression of small ubiquitin‑related modifier (SUMO) and sirtuin 1 (SIRT1) proteins, and to examine interactions between these proteins in premature neonates with bronchopulmonary dysplasia (BPD). Peripheral blood mononuclear cells (PBMCs) were isolated from residual venous blood samples of 20 premature infants with BPD and 20 gender‑matched premature infants without BPD (non‑BPD group). Expression levels of SUMO and SIRT1 proteins in PBMCs were assessed by western blot analysis, and their interactions in PBMCs were detected using the immunoprecipitation assay. Based on the fraction of inspired oxygen (FiO2) administered, neonates were divided into normoxia, low‑(21%
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Tan F, Dong W, Lei X, Liu X, Li Q, Kang L, Zhao S and Zhang C: Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia. Mol Med Rep 17: 1283-1288, 2018
APA
Tan, F., Dong, W., Lei, X., Liu, X., Li, Q., Kang, L. ... Zhang, C. (2018). Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia. Molecular Medicine Reports, 17, 1283-1288. https://doi.org/10.3892/mmr.2017.8012
MLA
Tan, F., Dong, W., Lei, X., Liu, X., Li, Q., Kang, L., Zhao, S., Zhang, C."Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia". Molecular Medicine Reports 17.1 (2018): 1283-1288.
Chicago
Tan, F., Dong, W., Lei, X., Liu, X., Li, Q., Kang, L., Zhao, S., Zhang, C."Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia". Molecular Medicine Reports 17, no. 1 (2018): 1283-1288. https://doi.org/10.3892/mmr.2017.8012