Open Access

Mesenchymal stem cells overexpressing adrenomedullin improve heart function through antifibrotic action in rats experiencing heart failure

  • Authors:
    • Li Li Li
    • Cheng Peng
    • Meiling Zhang
    • Yumei Liu
    • Hefei Li
    • Huibo Chen
    • Yu Sun
    • Chunjun Zhu
    • Yao Zhang
  • View Affiliations

  • Published online on: November 14, 2017     https://doi.org/10.3892/mmr.2017.8049
  • Pages: 1437-1444
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Previous studies of the authors have indicated that the transplantation of mesenchymal stem cells (MSCs) can attenuate cardiac fibrosis through the secretion of antifibrotic factors, such as adrenomedullin (ADM). Therefore, the authors addressed the hypothesis that ADM overexpression could enhance the antifibrotic effect of MSCs transplantation in a rat model of heart failure. The results of the present study demonstrated that, compared with the group that received the GFP‑MSCs, the transplantation of ADM‑MSCs significantly improved heart function and decreased the percentage of fibrotic area and the expression of matrix metalloproteinase 2. In addition, fluorescence microscopy indicated that the survival of transplanted MSCs also increased significantly in the ADM‑MSCs‑treated group. Furthermore, the expression of fibrosis‑related genes, such as ADM and hepatocyte growth factor, were significantly influenced in the ADM‑MSCs‑treated group. Based on these findings, it may be concluded that, compared with MSCs, MSCs overexpressing ADM can further improve heart function in rats experiencing heart failure through enhanced antifibrotic activity.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li LL, Peng C, Zhang M, Liu Y, Li H, Chen H, Sun Y, Zhu C and Zhang Y: Mesenchymal stem cells overexpressing adrenomedullin improve heart function through antifibrotic action in rats experiencing heart failure. Mol Med Rep 17: 1437-1444, 2018
APA
Li, L.L., Peng, C., Zhang, M., Liu, Y., Li, H., Chen, H. ... Zhang, Y. (2018). Mesenchymal stem cells overexpressing adrenomedullin improve heart function through antifibrotic action in rats experiencing heart failure. Molecular Medicine Reports, 17, 1437-1444. https://doi.org/10.3892/mmr.2017.8049
MLA
Li, L. L., Peng, C., Zhang, M., Liu, Y., Li, H., Chen, H., Sun, Y., Zhu, C., Zhang, Y."Mesenchymal stem cells overexpressing adrenomedullin improve heart function through antifibrotic action in rats experiencing heart failure". Molecular Medicine Reports 17.1 (2018): 1437-1444.
Chicago
Li, L. L., Peng, C., Zhang, M., Liu, Y., Li, H., Chen, H., Sun, Y., Zhu, C., Zhang, Y."Mesenchymal stem cells overexpressing adrenomedullin improve heart function through antifibrotic action in rats experiencing heart failure". Molecular Medicine Reports 17, no. 1 (2018): 1437-1444. https://doi.org/10.3892/mmr.2017.8049