Open Access

Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome

  • Authors:
    • Hua Mei
    • Yuheng Zhang
    • Chunzhi Liu
    • Yayu Zhang
    • Chunli Liu
    • Dan Song
    • Chun Xin
    • Jing Wang
    • Jonathan Josephs‑Spaulding
    • Yan Zhu
    • Feng Tang
  • View Affiliations

  • Published online on: October 26, 2017     https://doi.org/10.3892/mmr.2017.7891
  • Pages:59-70
  • Copyright: © Mei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypoxemia and hypercarbia resulting from a lack of surfactant is considered to be the primary mechanism underlying neonatal respiratory distress syndrome (NRDS). Surfactant replacement therapy may mitigate the symptoms of the disease by decreasing the surface tension of alveoli and facilitating inflation. However, surfactant serves an additional role in immunological processes. Therefore, it may be hypothesized that mechanisms of NRDS involving surfactant exert additional functions to promoting alveolar inflation. Using peripheral blood obtained from mature infants with and without NRDS, in tandem with mRNA sequencing (mRNA‑seq) analysis, the present study identified that, while cell cycle regulation and alveolar surfactants serve a role in deterring the further onset of NRDS, innate and pathogen‑induced responses of the immune system are among the most important factors in the pathology. The present study illustrated the regulatory importance of these immune pathways in response to alterations in the expression of gene families, particularly in perpetual lung injury leading to NRDS. Notably, data collected from the mRNA‑seq analysis revealed similar mechanisms between NRDS and acute respiratory distress syndrome, a clinical phenotype precipitated by the manifestation of a severe form of lung injury due to numerous lung insults, implying that similar therapies may be applied to treat these two diseases.

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January 2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
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APA
Mei, H., Zhang, Y., Liu, C., Zhang, Y., Liu, C., Song, D. ... Tang, F. (2018). Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome. Molecular Medicine Reports, 17, 59-70. https://doi.org/10.3892/mmr.2017.7891
MLA
Mei, H., Zhang, Y., Liu, C., Zhang, Y., Liu, C., Song, D., Xin, C., Wang, J., Josephs‑Spaulding, J., Zhu, Y., Tang, F."Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome". Molecular Medicine Reports 17.1 (2018): 59-70.
Chicago
Mei, H., Zhang, Y., Liu, C., Zhang, Y., Liu, C., Song, D., Xin, C., Wang, J., Josephs‑Spaulding, J., Zhu, Y., Tang, F."Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome". Molecular Medicine Reports 17, no. 1 (2018): 59-70. https://doi.org/10.3892/mmr.2017.7891