Open Access

Acetylshikonin suppresses invasion of Porphyromonas gingivalis‑infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis

  • Authors:
    • Bong‑Hae Cho
    • Yun‑Hoa Jung
    • Da Jeong Kim
    • Bok Hee Woo
    • Ji Eun Jung
    • Ji Hye Lee
    • Young Whan Choi
    • Hae Ryoun Park
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/mmr.2017.8151
  • Pages: 2327-2334
  • Copyright: © Cho et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli within the tumor microenvironment. Accordingly, the identification of agents that can suppress the inflammation‑promoted invasiveness of cancer cells may be important in treating cancer and improving the prognosis of patients with cancer. Acetylshikonin, a flavonoid with anti‑inflammatory activity, inhibits proliferation and induces apoptosis of oral cancer cells. In the present study, the anti‑invasive effect of acetylshikonin on YD10B oral cancer cells infected with Porphyromonas gingivalis, a major pathogen of chronic periodontitis, and the mechanisms involved were investigated. Firstly, we examined whether P. gingivalis infection increased the invasiveness of YD10B cells. Results suggested that YD10B oral cancer cells become more aggressive when they are infected with P. gingivalis. Secondly, acetylshikonin significantly inhibited the invasion of P. gingivalis‑infected YD10B cells by suppressing IL‑8 release and IL‑8‑dependent MMP release. These data suggest that acetylshikonin may be a useful preventive and therapeutic candidate for oral cancer that is chronically infected with periodontal pathogens.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Cho BH, Jung YH, Kim DJ, Woo BH, Jung JE, Lee JH, Choi YW and Park HR: Acetylshikonin suppresses invasion of Porphyromonas gingivalis‑infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis. Mol Med Rep 17: 2327-2334, 2018.
APA
Cho, B., Jung, Y., Kim, D.J., Woo, B.H., Jung, J.E., Lee, J.H. ... Park, H.R. (2018). Acetylshikonin suppresses invasion of Porphyromonas gingivalis‑infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis. Molecular Medicine Reports, 17, 2327-2334. https://doi.org/10.3892/mmr.2017.8151
MLA
Cho, B., Jung, Y., Kim, D. J., Woo, B. H., Jung, J. E., Lee, J. H., Choi, Y. W., Park, H. R."Acetylshikonin suppresses invasion of Porphyromonas gingivalis‑infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis". Molecular Medicine Reports 17.2 (2018): 2327-2334.
Chicago
Cho, B., Jung, Y., Kim, D. J., Woo, B. H., Jung, J. E., Lee, J. H., Choi, Y. W., Park, H. R."Acetylshikonin suppresses invasion of Porphyromonas gingivalis‑infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis". Molecular Medicine Reports 17, no. 2 (2018): 2327-2334. https://doi.org/10.3892/mmr.2017.8151