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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February-2018 Volume 17 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Current status and future prospects of the strategy of combining CAR‑T with PD‑1 blockade for antitumor therapy (Review)

Jinjing Xu, Qing Zhang, Kang Tian, Haiyu Wang, Hong Yin, Junnian Zheng
Pages: 2083-2088
Published online on: 22 November 2017

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Review Open Access

The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review)

Emmanuel Papadakis, Meletios Kanakis, Agapi Kataki, Demetrios A. Spandidos
Pages: 2089-2099
Published online on: 28 November 2017

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Article Open Access

Exploiting novel valve interstitial cell lines to study calcific aortic valve disease

Hiu‑Gwen Tsang, Lin Cui, Colin Farquharson, Brendan M. Corcoran, Kim M. Summers, Vicky E. Macrae
Pages: 2100-2106
Published online on: 27 November 2017

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Article Open Access

Clinical significance of CCBE1 expression in lung cancer

Peng Li, Zhuangzhuang Cong, Yong Qiang, Lei Xiong, Li Tang, Yu Zhang, Haiwei Wu, Jun Yi, Hua Jing, Demin Li, Yi Shen
Pages: 2107-2112
Published online on: 29 November 2017

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Article Open Access

Downregulation of miR‑29b targets DNMT3b to suppress cellular apoptosis and enhance proliferation in pancreatic cancer Retraction in /10.3892/mmr.2023.13049

Li‑Hua Wang, Ju Huang, Cheng‑Rong Wu, Liu‑Ye Huang, Jun Cui, Zhi‑Zhi Xing, Chun‑Yu Zhao
Pages: 2113-2120
Published online on: 23 November 2017

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Article Open Access

Increased serum protein levels by Yuanshi Shengmai Chenggu Tablet in treatment of avascular osteonecrosis of the femoral head

Jianchun Zeng, Peng Deng, Jie Li, Wenjun Feng, Jinlun Chen, Yirong Zeng
Pages: 2121-2126
Published online on: 20 November 2017

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Article Open Access

Spontaneous hypothermia ameliorated inflammation and neurologic deficit in rat cardiac arrest models following resuscitation

Minggen Zhou, Peng Wang, Zhengfei Yang, Haidong Wu, Zitong Huan
Pages: 2127-2136
Published online on: 20 November 2017

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Article Open Access

Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism

Ting‑Jun Jiang, Xue‑Liang Cao, Sha Luan, Wan‑Hui Cui, Si‑Huang Qiu, Yi‑Chao Wang, Chang‑Jiu Zhao, Peng Fu
Pages: 2137-2144
Published online on: 27 November 2017

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Article Open Access

Prazosin protects myocardial cells against anoxia-reoxygenation injury via the extracellular signal‑regulated kinase signaling pathway

Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui
Pages: 2145-2152
Published online on: 28 November 2017

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Article Open Access

Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10 Retraction in /10.3892/mmr.2023.13109

Zhen Zhou, Yi Zhao, Lingping Gu, Xiaoming Niu, Shun Lu
Pages: 2153-2160
Published online on: 28 November 2017

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Article Open Access

Microarray analysis reveals gene and microRNA signatures in diabetic kidney disease

Chengji Cui, Yabin Cui, Yanyan Fu, Sichao Ma, Shoulin Zhang
Pages: 2161-2168
Published online on: 28 November 2017

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Article Open Access

Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout

Jingjing Zhang, Junli Zhao, Xiaojing Zheng, Kai Cai, Qinwen Mao, Haibin Xia
Pages: 2169-2176
Published online on: 22 November 2017

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Article Open Access

Genes and pathways associated with the occurrence of malignancy in benign lymphoepithelial lesions

Yao Mawulikplimi Adzavon, Pengxiang Zhao, Xin Zhang, Mengyu Liu, Baobei Lv, Linqi Yang, Xujuan Zhang, Fei Xie, Mingzi Zhang, Jianmin Ma, Xuemei Ma
Pages: 2177-2186
Published online on: 24 November 2017

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Article Open Access

Antiangiogenic effects of catalpol on rat corneal neovascularization

Yun Han, Mei Shen, Li‑Yuan Tang, Gang Tan, Qi‑Chen Yang, Lei Ye, Lin‑Hong Ye, Nan Jiang, Gui‑Ping Gao, Yi Shao
Pages: 2187-2194
Published online on: 20 November 2017

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Article Open Access

KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease

Sen Wang, Yong Hou, Weiping Chen, Jianmin Wang, Weihua Xie, Xiaoping Zhang, Li Zeng
Pages: 2195-2202
Published online on: 20 November 2017

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Article Open Access

N-acetylcysteine ameliorates contrast‑induced kidney injury in rats with unilateral hydronephrosis

Qiang Xia, Chunxiao Liu, Xia Zheng
Pages: 2203-2210
Published online on: 21 November 2017

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Article Open Access

Potential role of microRNA‑223‑3p in the tumorigenesis of hepatocellular carcinoma: A comprehensive study based on data mining and bioinformatics

Rui Zhang, Li‑Jie Zhang, Mei‑Ling Yang, Lan‑Shan Huang, Gang Chen, Zhen‑Bo Feng
Pages: 2211-2228
Published online on: 27 November 2017

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Article Open Access

TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention

Xiao Yang, Gan Tao Chen, Yan Qing Wang, Shu Xian, Li Zhang, Shao Ming Zhu, Feng Pan, Yan Xiang Cheng
Pages: 2229-2238
Published online on: 20 November 2017

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Article Open Access

UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer

Xiang‑Rong Liu, Li‑Hua Zhou, Jian‑Xin Hu, Li‑Min Liu, Hui‑Ping Wan, Xi‑Quan Zhang
Pages: 2239-2244
Published online on: 29 November 2017

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Article Open Access

Targeted next‑generation sequencing reveals two novel mutations of NBAS in a patient with infantile liver failure syndrome‑2

Jiao Wang, Zhongji Pu, Zhenhua Lu
Pages: 2245-2250
Published online on: 29 November 2017

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Article Open Access

Epigenetic alterations of the Igf2 promoter and the effect of miR‑483‑5p on its target gene expression in esophageal squamous cell carcinoma

Han Zhang, Xiaowei Shi, Weidong Chang, Yingying Li, Li Wang, Linsong Wang
Pages: 2251-2256
Published online on: 22 November 2017

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Article Open Access

Ran-binding protein M is associated with human spermatogenesis and oogenesis

Wen‑Hao Tang, Xin‑Jie Zhuang, Shi‑De Song, Han Wu, Zhe Zhang, Yu‑Zhuo Yang, Hong‑Liang Zhang, Jia‑Ming Mao, De‑Feng Liu, Lian‑Ming Zhao, Hao‑Cheng Lin, Kai Hong, Lu‑Lin Ma, Jie Qiao, Weibing Qin, Yunge Tang, Hui Jiang
Pages: 2257-2262
Published online on: 23 November 2017

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Article Open Access

Modular organization of a hypocretin gene minimal promoter

Adriana Sánchez‑García, Griselda A. Cabral‑Pacheco, Viviana C. Zomosa‑Signoret, Rocío Ortiz‑López, Alberto Camacho, Paulo M. Tabera‑Tarello, José A. Garnica-López, Román Vidaltamayo
Pages: 2263-2270
Published online on: 22 November 2017

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Article Open Access

Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro

Xiao‑Bo He, Tao Ma, Wei Zheng, Qing‑He Geng, Kai‑Jin Guo
Pages: 2271-2276
Published online on: 20 November 2017

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Article Open Access

Stimulation of chondrocytes and chondroinduced mesenchymal stem cells by osteoinduced mesenchymal stem cells under a fluid flow stimulus on an integrated microfluidic device

Xuanwen Bao, Zhongyu Li, Hui Liu, Ke Feng, Fangchao Yin, Hongjing Li, Jianhua Qin
Pages: 2277-2288
Published online on: 24 November 2017

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Article Open Access

P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model

Lingdan Dong, Yanhong Hu, Long Zhou, Xianglin Cheng
Pages: 2289-2296
Published online on: 22 November 2017

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Article Open Access

Diagnostic significance and potential function of miR-338-5p in hepatocellular carcinoma: A bioinformatics study with microarray and RNA sequencing data

Liang Liang, Li Gao, Xiao‑Ping Zou, Meng‑Lan Huang, Gang Chen, Jian‑Jun Li, Xiao‑Yong Cai
Pages: 2297-2312
Published online on: 21 November 2017

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Article Open Access

Estrogen inhibits the overgrowth of Escherichia coli in the rat intestine under simulated microgravity

Yongtao Yang, Changmin Qu, Shuwen Liang, Gang Wang, Haolun Han, Na Chen, Xiaoying Wang, Zhiwen Luo, Changqing Zhong, Yan Chen, Lianyong Li, Wei Wu
Pages: 2313-2320
Published online on: 20 November 2017

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Article Open Access

Forskolin attenuates retinal inflammation in diabetic mice

Zhi‑Peng You, Bin Xiong, Yu‑Lan Zhang, Lu Shi, Ke Shi
Pages: 2321-2326
Published online on: 20 November 2017

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Article Open Access

Acetylshikonin suppresses invasion of Porphyromonas gingivalis‑infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis

Bong‑Hae Cho, Yun‑Hoa Jung, Da Jeong Kim, Bok Hee Woo, Ji Eun Jung, Ji Hye Lee, Young Whan Choi, Hae Ryoun Park
Pages: 2327-2334
Published online on: 24 November 2017

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Article Open Access

Retinal microvasculature alteration in central serous chorioretinopathy

Li Yu, Yi Shao, Yong Chai, Lin‑Hong Ye, Qi‑Chen Yang, Lei Ye, Qing Yuan, Nan Jiang, Jing‑Lin Yi
Pages: 2335-2340
Published online on: 21 November 2017

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Article Open Access

miR-33a hinders the differentiation of adipose mesenchymal stem cells towards urothelial cells in an inductive condition by targeting β‑catenin and TGFR

Gang Fan, Zhenzhou Xu, Xiang Hu, Mingfeng Li, Jie Zhou, Yong Zeng, Yu Xie
Pages: 2341-2348
Published online on: 27 November 2017

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Article Open Access

bFGF promotes Sca‑1+ cardiac stem cell migration through activation of the PI3K/Akt pathway

Lin Ling, Shaohua Gu, Yan Cheng, Liucheng Ding
Pages: 2349-2356
Published online on: 28 November 2017

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Article Open Access

DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway

Jintao Du, Xianren Wang, Xiaobo Zhang, Xuemei Zhang, Hongyan Jiang
Pages: 2357-2365
Published online on: 20 November 2017

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Article Open Access

High glucose/lysophosphatidylcholine levels stimulate extracellular matrix deposition in diabetic nephropathy via platelet‑activating factor receptor

Su‑Xian Zhou, Dong‑Mei Huo, Xiao‑Yun He, Ping Yu, Yan‑Hua Xiao, Chun‑Lin Ou, Ren-Mei Jiang, Dan Li, Hao Li
Pages: 2366-2372
Published online on: 20 November 2017

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Article Open Access

Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer

Yan Li, Chunxia Liu, Ke Tang, Yan Chen, Kang Tian, Zhiqiang Feng, Jindong Chen
Pages: 2373-2383
Published online on: 28 November 2017

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Article Open Access

Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway Retraction in /10.3892/mmr.2025.13435

Yukun Zu, Jianning Wang, Wei Ping, Wei Sun
Pages: 2384-2392
Published online on: 24 November 2017

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Article Open Access

Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells

Weiji Ding, Yunda Zhang, Huali Cai, Gang Liu, Yongzhi Ye, Guoxing Xu, Haibin Wang, Disheng Xiong, Chuankai Zhang, Zhengjie Huang, Qi Luo
Pages: 2393-2401
Published online on: 27 November 2017

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Article Open Access

Molecular basis of coronary artery dilation and aneurysms in patients with Kawasaki disease based on differential protein expression

Wanting Liu, Chaowu Liu, Li Zhang, Xiaofei Xie, Xiaoqiong Gu, Chuanlan Sang, Mingguo Xu, Weijun Xu, Hongling Jia
Pages: 2402-2414
Published online on: 20 November 2017

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Article Open Access

Lycium barbarum polysaccharide arbitrates palmitate-induced apoptosis in MC3T3‑E1 cells through decreasing the activation of ERS‑mediated apoptosis pathway

Lei Jing, Xue‑Wen Jia
Pages: 2415-2421
Published online on: 21 November 2017

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Article Open Access

LncRNA TUG1 serves an important role in hypoxia-induced myocardial cell injury by regulating the miR‑145‑5p‑Binp3 axis Retraction in /10.3892/mmr.2024.13232

Zhongwei Wu, Shengji Zhao, Chunfu Li, Chaoquan Liu
Pages: 2422-2430
Published online on: 20 November 2017

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Article Open Access

Lysyl oxidases expression and histopathological changes of the diabetic rat nephron

Jun Chen, Jie Ren, Wings T.Y. Loo, Liang Hao, Min Wang
Pages: 2431-2441
Published online on: 29 November 2017

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Article Open Access

Radiolabeled methotrexate as a diagnostic agent of inflammatory target sites: A proof-of-concept study

Maria Papachristou, George A. Kastis, Petros Z. Stavrou, Stavros Xanthopoulos, Lars R. Furenlid, Ioannis E. Datseris, Penelope Bouziotis
Pages: 2442-2448
Published online on: 27 November 2017

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Article Open Access

The antibacterial effect of topical ozone on the treatment of MRSA skin infection

Mingsheng Song, Qinghai Zeng, Yaping Xiang, Lihua Gao, Jian Huang, Jinhua Huang, Kathy Wu, Jianyun Lu
Pages: 2449-2455
Published online on: 24 November 2017

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Article Open Access

Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma

Guixia Wu, Jing Li, Jinqiao Yue, Shuying Zhang, Kurexi Yunusi
Pages: 2456-2464
Published online on: 29 November 2017

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Article Open Access

Calcium channels are involved in EphB/ephrinB reverse signaling‑induced apoptosis in a rat chronic ocular hypertension model

Lingdan Dong, Xianglin Cheng, Long Zhou, Yanhong Hu
Pages: 2465-2471
Published online on: 27 November 2017

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Article

Interference of Notch 1 inhibits the proliferation and invasion of breast cancer cells: Involvement of the β‑catenin signaling pathway

Xi Xi Lai, Gang Li, Baochai Lin, Han Yang
Pages: 2472-2478
Published online on: 27 November 2017

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Article

Resveratrol attenuates hydrogen peroxide‑induced apoptosis, reactive oxygen species generation, and PSGL‑1 and VWF activation in human umbilical vein endothelial cells, potentially via MAPK signalling pathways

Zhenkai Lou, Xingguo Li, Xueling Zhao, Kaili Du, Xing Li, Bing Wang
Pages: 2479-2487
Published online on: 21 November 2017

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Article

Elderly apolipoprotein E‑/‑ mice with advanced atherosclerotic lesions in the aorta do not develop Alzheimer's disease-like pathologies

Reut Shnerb Ganor, Dror Harats, Ginette Schiby, Kinneret Rosenblatt, Irit Lubitz, Aviv Shaish, Ophira Salomon
Pages: 2488-2492
Published online on: 21 November 2017

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Article

Downregulation of 14-3-3β inhibits proliferation and migration in osteosarcoma cells

Quanming Wu, Jianwei Zhu, Fan Liu, Jin Liu, Mingpeng Li
Pages: 2493-2500
Published online on: 22 November 2017

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Article

Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB

Xinyi Yang, Xiaoli Zhu, Haiyan Ji, Junxiao Deng, Panpan Lu, Zhengtao Jiang, Xian Li, Yibo Wang, Chuqiao Wang, Jingya Zhao, Yanan Wang, Yangcheng Zhong, He Yang, Huanzhang Zhu
Pages: 2501-2508
Published online on: 29 November 2017

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Article

Effect of TW37 on the growth of H1975 EGFR‑TKI‑resistant lung cancer cells and its underlying mechanisms

Jixian Liu, Xinhuang Yao, Da Wu, Yiwang Ye, Qiang Wu, Suyue Liu, Hao Wu
Pages: 2509-2514
Published online on: 29 November 2017

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Article

Potential inhibitory effects of the traditional herbal prescription Hyangso-san against skin inflammation via inhibition of chemokine production and inactivation of STAT1 in HaCaT keratinocytes

Hye‑Sun Lim, Sae‑Rom Yo, Mee‑Young Lee, Chang‑Seob Seo, Hyeun‑Kyoo Shin, Soo‑Jin Jeong
Pages: 2515-2522
Published online on: 28 November 2017

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Article

Oxysophoridine rescues spinal cord injury via anti‑inflammatory, anti‑oxidative stress and anti‑apoptosis effects

Zhong Cao, Liang Chen, Yanbin Liu, Tao Peng
Pages: 2523-2528
Published online on: 28 November 2017

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Article

Therapeutic effect of adipose‑derived stem cell transplantation on optic nerve injury in rats

Xu Li, Shanyao Zhao, Liangjun Wang
Pages: 2529-2534
Published online on: 20 November 2017

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Article

FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in /10.3892/mmr.2017.8356

Han Yan, Anhua Wu
Pages: 2535-2542
Published online on: 23 November 2017

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Article

Integrated analysis of gene expression and copy number variations in MET proto‑oncogene‑transformed human primary osteoblasts

Ru‑Jiang Jia, Chun‑Gen Lan, Xiu‑Chao Wang, Chun‑Tao Gao
Pages: 2543-2548
Published online on: 22 November 2017

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Article

Role of DDAH/ADMA pathway in TGF-β1-mediated activation of hepatic stellate cells

Zhenguo Liu, Juan Wang, Wu Xing, Yingqiong Peng, Yan Huang, Xuegong Fan
Pages: 2549-2556
Published online on: 20 November 2017

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Article

Identification of susceptibility loci for thoracic ossification of the posterior longitudinal ligament by whole-genome sequencing

Peng Wang, Xiao Liu, Bin Zhu, Yunlong Ma, Lei Yong, Ze Teng, Yongqiang Wang, Chen Liang, Guanping He, Xiaoguang Liu
Pages: 2557-2564
Published online on: 28 November 2017

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Article

Autophagy regulates proliferation and biliary differentiation of hepatic oval cells via the MAPK/ERK signaling pathway

Dongdong Chen, Xiaoxiao Wu, Jie Zheng, Ruijie Dai, Zhichao Mo, Fahad Munir, Xiaolong Ni, Yunfeng Shan
Pages: 2565-2571
Published online on: 27 November 2017

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Ethanol extract from Cnidium monnieri (L.) Cusson induces cell cycle arrest and apoptosis via regulation of the p53‑independent pathway in HepG2 and Hep3B hepatocellular carcinoma cells

Eun Gyeong Lim, Guen Tae Kim, Bo Min Kim, Eun Ji Kim, Sang‑Yong Kim, Young Min Kim
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IRF3 signaling pathway serves an important role in poly(I:C)-induced procollagen reduction in human skin fibroblasts

Cheng Yao, Sangbum Han, Chi‑Hyun Park, Ye‑Ji Kim, Dong Hun Lee, Jin Ho Chung
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Downregulation of miR‑146a promotes proliferation and migration of AOB‑treated embryoid body via PDGFRA induction

Lejing Li, Shoulian Zhu, Ying Li, Wenyuan Cao, Xiaoli Qiao
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Fibroblast activation protein-α in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways

Feng Cao, Songsong Wang, Huanqin Wang, Wei Tang
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H19 functions as a competing endogenous RNA to regulate human epidermal growth factor receptor expression by sequestering let‑7c in gastric cancer

Yueguang Wei, Zhaoyang Liu, Jinhui Fang
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Effect of Atractylodes macrocephala rhizoma on isoproterenol‑induced ventricular remodeling in rats

Xiao‑Hua Cui, Hui‑Lin Wang, Rong Wu, Ping‑An Yao, Ke‑Zhao Wei, Jian‑Ping Gao
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Overexpression of p16ink4a regulates the Wnt/β‑catenin signaling pathway in pancreatic cancer cells

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All‑trans retinoic acid reduces endothelin‑1 expression and increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis

Linlin Tao, Yumei Nie, Ganxian Wang, Yanhui Ding, Junli Ding, Fangyuan Xiong, Songtao Tang, Yuan Wang, Birong Zhou, Huaqing Zhu
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Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways

Ling‑Qi Meng, Chang Liu, Ying‑Hua Luo, Xian‑Ji Piao, Yue Wang, Yi Zhang, Jia‑Ru Wang, Hao Wang, Wan‑Ting Xu, Yang Liu, Yi‑Qin Wu, Hu‑Nan Sun, Ying‑Hao Han, Mei‑Hua Jin, Gui‑Nan Shen, Yan‑Qing Zang, Jing Li, Nan‑Zhu Fang, Yu‑Dong Cui, Cheng‑Hao Jin
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Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells

Guang Sun, Bo Peng, Quan Xie, Jianwen Ruan, Xianwen Liang
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EZH2 inhibition sensitizes tamoxifen‑resistant breast cancer cells through cell cycle regulation

Si Chen, Fan Yao, Qinghuan Xiao, Qiannan Liu, Yikun Yang, Xuejuan Li, Guanglie Jiang, Takayoshi Kuno, Yue Fang
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Screening and identification of differentially expressed serum proteins in patients with vitiligo using two‑dimensional gel electrophoresis coupled with mass spectrometry

Yi‑Lei Li, Rui‑Qun Qi, Yang Yang, He‑Xiao Wang, Hang‑Hang Jiang, Zheng‑Xiu Li, Bi‑Huan Xiao, Song Zheng, Yu‑Xiao Hong, Jiu‑Hong Li, Hong‑Duo Chen, Xing‑Hua Gao
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Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration

Hong Zhou, Qi Wu, Luqing Wei, Shouchun Peng
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Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia

Sang‑Mi Woo, Kang Min Lee, Gyu Ri Lee, Ji Youn Park, Hee Jae Lee, Hyo‑Jung Bahn, Hyun Seok Yoon, Jem Yung Kim, Young Cheol Shin, Sung‑Gook Cho, Seong‑Gyu Ko
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NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB pathway, in phorbol 12-myristate 13-acetate-induced macrophages

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Ye Young Shin, Jea Sic Jeong, Mee‑Na Park, Jae‑Eon Lee, Sung‑Min An, Wan‑Seob Cho, Seung Chul Kim, Beum‑Soo An, Kyu‑Sup Lee
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Protective effect of baicalin against severe burn‑induced remote acute lung injury in rats

Chongfeng Bai, Tao Li, Qing Sun, Qun Xin, Tongyi Xu, Jinjian Yu, Yun Wang, Li Wei
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Long intergenic non‑coding RNA‑p21 mediates cardiac senescence via the Wnt/β‑catenin signaling pathway in doxorubicin-induced cardiotoxicity

Zhongdong Xie, Wenzheng Xia, Meng Hou
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Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse

Yang Li, Li Hong, Cheng Liu, Jie Min, Shasha Hong, Ming Hu, Yang Zhao, Qing Yang, Jianming Tang, Songming He
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microRNA-363-3p inhibits cell growth and invasion of non‑small cell lung cancer by targeting HMGA2 Retraction in /10.3892/mmr.2023.13034

Chuanfu Jiang, Yang Cao, Ting Lei, Yu Wang, Junfeng Fu, Ze Wang, Zhenyang Lv
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Honokiol induces autophagy and apoptosis of osteosarcoma through PI3K/Akt/mTOR signaling pathway

Zhiquan Li, Hui Dong, Mo Li, Yaoping Wu, Yanwu Liu, Yinan Zhao, Xiaochao Chen, Minliang Ma
Pages: 2719-2723
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MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF‑κB and VEGF pathway

Fengli Che, Huishan Du, Weidong Zhang, Zhe Cheng, Yanna Tong
Pages: 2724-2730
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Mechanism of triptolide in treating ankylosing spondylitis through the anti‑ossification effect of the BMP/Smad signaling pathway

Guilong Wang, Jing Cai, Jinshan Zhang, Cuiyun Li
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In vitro expression of mutant factor VII proteins and characterization of their clinical significance

Amir Mashayekhi, Shirin Shahbazi, Mirdavood Omrani, Reza Mahdian
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LncRNA SNHG12 regulates gastric cancer progression by acting as a molecular sponge of miR‑320

Hanyun Zhang, Wenjie Lu
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The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway

Xueqiang Zhu, Hui Huang, Jun Zhang, Hao Liu, Rui Ao, Ming Xiao, Yuelei Wu
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Neuroglobin promotes the proliferation and suppresses the apoptosis of glioma cells by activating the PI3K/AKT pathway

Bei Zhang, Yong Liu, Yajun Li, Xiao Zhe, Shijun Zhang, Lei Zhang
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Therapeutic effect of herb residue fermentation supernatant on spleen‑deficient mice

Xiaoxiao Zhao, Tingtao Chen, Fanjing Meng, Huan Wang, Puyuan Tian, Xianyao Tang, Xin Wang, Xiaolei Wang, Hongbo Xin, Hua Wei
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Long non‑coding nuclear paraspeckle assembly transcript 1 acts as prognosis biomarker and increases cell growth and invasion in cervical cancer by sequestering microRNA‑101

Li Wang, Hongying Zhu
Pages: 2771-2777
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Increased soluble ST2 and IL‑4 serum levels are associated with disease severity in patients with membranous nephropathy

Zhihui Zhang, Xiaolei Liu, Haifeng Wang, Zhihui Qu, Rebecca Crew, Nan Zhang, Yanfang Jiang
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Eaf2 protects human lens epithelial cells against oxidative stress‑induced apoptosis by Wnt signaling

Ke Feng, Hai‑Ke Guo
Pages: 2795-2802
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Histone deacetylase 2 is involved in µ‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain

Yong‑Hui Liao, Jian Wang, Yan‑Yan Wei, Ting Zhang, Yong Zhang, Zhong‑Fu Zuo, Xiao‑Yu Teng, Yun‑Qing Li
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Prenatal diagnosis of sex chromosomal inversion, translocation and deletion

Lin Zhang, Meihong Ren, Guining Song, Yang Zhang, Xuexia Liu, Xiaohong Zhang, Jianliu Wang
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Identification of abnormal nuclear and mitochondrial genes in esophageal cancer cells

Zongwen Liu, Ting Chai, Yan Zhang, Alan Chu, Bing Liang, Xing Guo, Zhenjiang Guo, Rui Song, Ge Hou, Jinjin Yuan, Yaohe Liu, Yuhao Zhang
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Proteomic analysis of synovial fluid in osteoarthritis using SWATH‑mass spectrometry

Weixiong Liao, Zhongli Li, Tanshi Li, Qiang Zhang, Heng Zhang, Xinzheng Wang
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Activation of the LKB1‑SIK1 signaling pathway inhibits the TGF‑β‑mediated epithelial‑mesenchymal transition and apoptosis resistance of ovarian carcinoma cells Retraction in /10.3892/mmr.2024.13180

Bo Hong, Jianmei Zhang, Wenlan Yang
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Bone morphogenetic protein 9 serves a protective role in response to ischemic‑reperfusion in the brain by promoting ERK activation

Yinling Feng, Yida Hu
Pages: 2845-2852
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Effect and mechanism of RNAi targeting WWTR1 on biological activity of gastric cancer cells SGC7901

Yuan Li, Fang‑Liang Yang, Chun‑Fu Zhu, Li‑Ming Tang
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Electrophysiological properties of strial pericytes and the effect of aspirin on pericyte K+ channels

Yan‑Hui Liu, Zhi‑Ping Zhang, Yang Wang, Jia Song, Ke‑Tao Ma, Jun‑Qiang Si, Li Li
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Crosstalk between human endometrial stromal cells and decidual NK cells promotes decidualization in vitro by upregulating IL‑25

Yuan Zhang, Ying Wang, Xiao‑Hui Wang, Wen‑Jie Zhou, Li‑Ping Jin, Ming‑Qing Li
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N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression

Ming Niu, Fei Ma, Jun Qian, Junwei Li, Tong Wang, Yuzhen Gao, Jian Jin
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High expression of FLT3 is a risk factor in leukemia

Jie Cheng, Lijun Qu, Jian Wang, Lemei Cheng, Yi Wang
Pages: 2885-2892
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Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension

Xiaobing Wang, Xueli Cai, Wu Wang, Yi Jin, Mayun Chen, Xiaoying Huang, Xiaochun Zhu, Liangxing Wang
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CRISPR/Cas9 targeting of the androgen receptor suppresses the growth of LNCaP human prostate cancer cells

Chaogang Wei, Fengjiao Wang, Wei Liu, Wenlu Zhao, Yi Yang, Kai Li, Li Xiao, Junkang Shen
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A multigene support vector machine predictor for metastasis of cutaneous melanoma

Dong Wei
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Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NF‑κB signaling pathway

Han Zhang, Nan Yang, Tianyue Wang, Bing Dai, Yunxiao Shang
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Urotensin II promotes aldosterone expression in rat aortic adventitial fibroblasts

Jun Li, Yong‑Gang Zhang, Li‑Min Luo, Xiao Dong, Wen‑Hui Ding, Shu‑Yi Dang
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Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism

Rui Yang, Qiang Jia, Xiao‑Fen Liu, Shan‑Feng Ma
Pages: 2929-2936
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COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression

Longhui Zhang, Sufen Li, Lan Li, Zhengqiong Chen, Ying Yang
Pages: 2937-2944
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Sulforaphane and myricetin act synergistically to induce apoptosis in 3T3‑L1 adipocytes

Anjun Yao, Yingzhuo Shen, Zhuangwei Zhang, Zuquan Zou, Anshi Wang, Shiyong Chen, Huiqin Zhang, Fen Chen, Jinshun Zhao, Zhongming Chen, Yujuan Shan, Xiaohong Zhang
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Insulin-like growth factor 1 inhibits autophagy of human colorectal carcinoma drug-resistant cells via the protein kinase B/mammalian target of rapamycin signaling pathway

Shuomin Wang, Kangsheng Gu
Pages: 2952-2956
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Neuroserpin restores autophagy and promotes functional recovery after acute spinal cord injury in rats

Zheng Li, Fubing Liu, Liang Zhang, Yuanwu Cao, Yunchao Shao, Xiaofeng Wang, Xiaoxing Jiang, Zixian Chen
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Shiyu Feng, Jie Yao, Zhibin Zhang, Yanyang Zhang, Zhiyuan Zhang, Jialin Liu, Wenlong Tan, Caihong Sun, Ling Chen, Xinguang Yu
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Yi Li, Yihao Wang, Hui Liu, Kai Ding, Shanfeng Hao, Yuanyuan Shao, Honglei Wang, Jin Chen, Lei Huang, Zonghong Shao, Rong Fu
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Twenty‑four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability

Jianyong Gao, Gang Tian, Xu Han, Qiang Zhu
Pages: 2982-2990
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Upregulation of miR‑598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression

Kun‑Ping Li, Yong‑Ping Fang, Jin‑Qi Liao, Jin‑Dong Duan, Li‑Guang Feng, Xiao‑Zai Luo, Zhi‑Jian Liang
Pages: 2991-2997
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A cellular spinal cord scaffold seeded with rat adipose‑derived stem cells facilitates functional recovery via enhancing axon regeneration in spinal cord injured rats

Hong Yin, Tao Jiang, Xi Deng, Miao Yu, Hui Xing, Xianjun Ren
Pages: 2998-3004
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Construction of a 26‑feature gene support vector machine classifier for smoking and non‑smoking lung adenocarcinoma sample classification

Lei Yang, Lu Sun, Wei Wang, Hao Xu, Yi Li, Jia‑Ying Zhao, Da‑Zhong Liu, Fei Wang, Lin‑You Zhang
Pages: 3005-3013
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Exploring of the molecular mechanism of rhinitis via bioinformatics methods

Yufen Song, Zhaohui Yan
Pages: 3014-3020
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MicroRNA‑138 promotes proliferation and suppresses mitochondrial depolarization in human pulmonary artery smooth muscle cells through targeting TASK‑1

Jin‑Jun Liu, Heng Zhang, Fang Xing, Bi Tang, Shi‑Li Wu, Ling Xuan, Pin‑Fang Kang, Qiong Xu, Hong‑Ju Wang, Ning‑Ru Zhang, Xiao‑Jing Wang
Pages: 3021-3027
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Profiles of differentially expressed genes and overexpression of NEBL indicates a positive prognosis in patients with colorectal cancer

Xiao Qiu, Jue‑Rong Feng, Fan Wang, Peng‑Fei Chen, Xiao‑Xing Chen, Rui Zhou, Ying Chang, Jing Liu, Qiu Zhao
Pages: 3028-3034
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Betulinic acid‑induced expression of nicotinamide adenine dinucleotide phosphate‑diaphorase in the immune organs of mice: A possible role of nitric oxide in immunomodulation

Kai Le Pang, Kavitha Vijayaraghavan, Badr Al Sayed, Mohamed Ali Seyed
Pages: 3035-3041
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Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database

Xinxing Lu, Lu Xue, Wenbin Sun, Jilu Ye, Zhiyun Zhu, Haifeng Mei
Pages: 3042-3054
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Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region

Bing Chun Yan, Jie Wang, Jianwen Cao, Moo‑Ho Won
Pages: 3055-3061
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Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway

Kai‑Fei Li, Chun‑Min Kang, Xiao‑Feng Yin, Hai‑Xia Li, Zhuo‑Yu Chen, Yao Li, Qiong Zhang, Yu‑Rong Qiu
Pages: 3062-3068
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Identification of key pathways and genes in Barrett's esophagus using integrated bioinformatics methods

Cong Zhang, Yujie Shen, Jiazheng Wang, Mingxia Zhou, Yingwei Chen
Pages: 3069-3077
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Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis

Lixue Zou, Jun Liu, Hougen Lu
Pages: 3078-3084
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Baicalein protects against endothelial cell injury by inhibiting the TLR4/NF‑κB signaling pathway

Chun‑Xia Wan, Man Xu, Si‑Hui Huang, Qing‑Qing Wu, Yuan Yuan, Wei Deng, Qi‑Zhu Tang
Pages: 3085-3091
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Neat1 regulates oxidized low-density lipoprotein-induced inflammation and lipid uptake in macrophages via paraspeckle formation

Ning Huang‑Fu, Jing‑Song Cheng, Yong Wang, Zhen‑Wei Li, Sheng‑Huang Wang
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Samchuleum attenuates diabetic renal injury through the regulation of TGF‑β/Smad signaling in human renal mesangial cells

Jung Joo Yoon, Yun Jung Lee, Seung Namgung, Byung Hyuk Han, Eun Sik Choi, Dae Gill Kang, Ho Sub Lee
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Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B

Fengxia Yan, Rifang Liao, Shaofen Lin, Xianguo Deng, Peter J. Little, Wenhua Zheng
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Upregulation of miR‑185 promotes apoptosis of the human gastric cancer cell line MGC803

Liqiao Fan, Bibo Tan, Yong Li, Qun Zhao, Hufang Yuan, Yu Liu, Dong Wang, Zhidong Zhang
Pages: 3115-3122
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HMGB1 suppresses colon carcinoma cell apoptosis triggered by co‑culture with dendritic cells via an ER stress‑associated autophagy pathway

Yingcheng Zheng, Guoguo Zhu
Pages: 3123-3132
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Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats

Shu Yu, Fangfang Liu, Chen Wang, Jingyi Zhang, An Zhu, Lingyue Zou, Aijie Han, Jin Li, Xuhong Chang, Yingbiao Sun
Pages: 3133-3139
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miR‑138 modulates prostate cancer cell invasion and migration via Wnt/β‑catenin pathway

Zhongwei Yu, Zulin Wang, Feng Li, Jiping Yang, Laikun Tang
Pages: 3140-3145
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Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway

Wei Wang, Wenli Hu
Pages: 3146-3151
Published online on: 06 December 2017

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Transcriptomic signature predicts the distant relapse in patients with ER+ breast cancer treated with tamoxifen for five years

Hao Zhou, Qingfu Lv, Zhaoji Guo
Pages: 3152-3157
Published online on: 08 December 2017

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Long non‑coding RNA FAF1 promotes intervertebral disc degeneration by targeting the Erk signaling pathway

Daguo Mi, Chunyue Cai, Bin Zhou, Xuan Liu, Peide Ma, Shuijie Shen, Wei Lu, Wei Huang
Pages: 3158-3163
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The cloning and activity of human Hes1 gene promoter

Hai Lu, Jinqun Jiang, Yi Gao
Pages: 3164-3169
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Loss of Shp2 within radial glia is associated with cerebral cortical dysplasia, glial defects of cerebellum and impaired sensory‑motor development in newborn mice

Yu Zhu, Jian Shen, Tianfu Sun, Hao Jiang, Kangli Xu, Thiti Samuthrat, Yicheng Xie, Yuxiang Weng, Yongda Li, Qiangmin Xie, Renya Zhan
Pages: 3170-3177
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Construction and protective immunogenicity of DNA vaccine pNMB0315 against Neisseria meningitidis serogroup B

Xiaoxia Wu, Kaiming Li, Meihua Xie, Minjun Yu, Shuangyang Tang, Zhenyu Li, Sihai Hu
Pages: 3178-3185
Published online on: 12 December 2017

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Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition

Jun Wang, Dan Li, Jincai Hou, Hongtao Lei
Pages: 3186-3193
Published online on: 07 December 2017

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Necrostatin-1 attenuates sepsis-associated acute kidney injury by promoting autophagosome elimination in renal tubular epithelial cells

Wei Dong, Zhilian Li, Yuanhan Chen, Li Zhang, Zhiming Ye, Huaban Liang, Ruizhao Li, Lixia Xu, Bin Zhang, Shuangxin Liu, Weidong Wang, Chunling Li, Wei Shi, Xinling Liang
Pages: 3194-3199
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Whole exome sequencing identifies a mutation in EYA1 and GLI3 in a patient with branchio‑otic syndrome and esophageal atresia: Coincidence or a digenic mode of inheritance?

Franziska Kause, Heiko Reutter, Florian Marsch, Holger Thiele, Janine Altmüller, Michael Ludwig, Rong Zhang
Pages: 3200-3205
Published online on: 06 December 2017

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Association of aquaporin‑1 with tumor migration, invasion and vasculogenic mimicry in glioblastoma multiforme

Wan‑Yong Yang, Ze‑Feng Tan, Da‑Wei Dong, Yan Ding, Heng Meng, Ying Zhao, Xiu‑Feng Xin, Wei Bi
Pages: 3206-3211
Published online on: 12 December 2017

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Article

Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

Peng Zou, Xiaoxiao Liu, Gang Li, Yangang Wang
Pages: 3212-3217
Published online on: 11 December 2017

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SPOCD1 promotes cell proliferation and inhibits cell apoptosis in human osteosarcoma

Jinqian Liang, Hong Zhao, Jianhua Hu, Yong Liu, Zheng Li
Pages: 3218-3225
Published online on: 12 December 2017

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Cancer‑testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells

Pumei Zeng, Ying Wang, Yutian Zheng, Xiao Song, Yanhui Yin
Pages: 3226-3231
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Article

Bis‑enoxacin blocks alveolar bone resorption in rats with ovariectomy‑induced osteoporosis

Xi Zhang, Xinchen Xu, Xuqiang Liu, Chuanyuan Mao, An Qin, Eryi Lu
Pages: 3232-3238
Published online on: 08 December 2017

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Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells

Xin Chen, Na Gu, Chao Xue, Ban‑Ruo Li
Pages: 3239-3245
Published online on: 12 December 2017

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Calcitonin gene‑related peptide reduces Porphyromonas gingivalis LPS‑induced TNF‑α release and apoptosis in osteoblasts

Yan Zhou, Huiyu Zhang, Gang Zhang, Yong He, Ping Zhang, Ziqi Sun, Yuxia Gao, Yinghui Tan
Pages: 3246-3254
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Article

c‑Jun N‑terminal kinase 3 signalling serves a potential role as a biomarker for determining the pathogenesis of Parkinson's disease

Xiu‑Li Yang, Chun‑Mei Gao
Pages: 3255-3259
Published online on: 11 December 2017

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Rui‑Jun Su, Jun‑Li Zhen, Wei Wang, Jian‑Liang Zhang, Yan Zheng, Xiao‑Min Wang
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MicroRNA‑675 inhibits cell proliferation and invasion in melanoma by directly targeting metadherin Retraction in /10.3892/mmr.2023.12986

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NF‑κB regulates HSF1 and c‑Jun activation in heat stress‑induced intestinal epithelial cell apoptosis

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The protective effect of umbelliferone ameliorates myocardial injury following ischemia‑reperfusion in the rat through suppression NLRP3 inflammasome and upregulating the PPAR-γ

Hongbo Luo, Zhengke Fan, Daokang Xiang, Zhenwei Jiang, Wenbin Zhang, Lufang Gao, Chao Feng
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TSLP/TSLPR promote angiogenesis following ischemic stroke via activation of the PI3K/AKT pathway

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Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis

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Pages: 3418-3424
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Macrophage migration inhibitory factor promotes cardiac fibroblast proliferation through the Src kinase signaling pathway

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[Erratum] Exogenous regucalcin suppresses the proliferation of human breast cancer MDA-MB-231 bone metastatic cells in vitro

Masayoshi Yamaguchi, Tomiyasu Murata
Pages: 3432-3432
Published online on: 12 December 2017

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CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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