Forkhead box protein C1 promotes cell proliferation and invasion in human cervical cancer

Wang,Lu; Chai,Lulu; Ji,Qingchun; Cheng,Rongjie; Wang,Jiao; Han,Shiyu

doi:10.3892/mmr.2018.8423

Forkhead box protein C1 promotes cell proliferation and invasion in human cervical cancer

Authors:
- Lu Wang
- Lulu Chai
- Qingchun Ji
- Rongjie Cheng
- Jiao Wang
- Shiyu Han
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Affiliations: Department of Gynecology and Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150037, P.R. China
Published online on: January 11, 2018 https://doi.org/10.3892/mmr.2018.8423
Pages: 4392-4398
Copyright : © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Increasing evidence has demonstrated that aberrant forkhead box protein C1 (FOXC1) expression contributes to tumorigenesis in multiple types of malignant tumor. However, the clinical significance and biological roles of FOXC1 in cervical cancer remain unknown. The expression levels of FOXC1 were examined in human cervical cancer tissues and cells using reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry and western blotting. Furthermore, high FOXC1 expression was significantly associated with advanced clinical stages, a high degree of malignancy and a poor outcome. FOXC1 silencing inhibited cell growth and enhanced cell apoptosis. Knockdown of FOXC1 markedly suppressed cell migration and invasion in vitro, and resulted in downregulation of phosphorylated‑RAC‑α serine/threonine‑protein kinase, proto‑oncogene c‑Myc and B‑cell lymphoma 2. In conclusion, these data indicated that upregulation of FOXC1 contributed to the development of cervical cancer by increasing the growth and motility of the cervical cancer cells, thereby worsening the disease progression in these patients.

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