Open Access

The roles of TRIO and F-actin-binding protein in glioblastoma cells

  • Authors:
    • Hyunji Lee
    • Minhee Kim
    • Jisoo Park
    • Quangdon Tran
    • Youngeun Hong
    • Hyeonjeong Cho
    • Sungjin Park
    • Suntaek Hong
    • Derek P. Brazil
    • Seon‑Hwan Kim
    • Jongsun Park
  • View Affiliations

  • Published online on: January 18, 2018     https://doi.org/10.3892/mmr.2018.8458
  • Pages: 4540-4546
  • Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F‑actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevated in U87‑MG and U343‑MG cells. Furthermore, the TrioBP mRNA expression level was markedly increased in U87‑MG and U251‑MG cells compared with that in cerebral cortex cells, as determined by deep sequencing. Comprehensive analysis of a public TCGA dataset confirmed that TrioBP expression is elevated in patients with glioblastoma. In summary, the present data indicate that TrioBP expression is increased in glioblastoma cell lines and in patients with glioma, suggesting that TrioBP has potential as a diagnostic marker or therapeutic agent for glioma.
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March-2018
Volume 17 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lee H, Kim M, Park J, Tran Q, Hong Y, Cho H, Park S, Hong S, Brazil DP, Kim SH, Kim SH, et al: The roles of TRIO and F-actin-binding protein in glioblastoma cells. Mol Med Rep 17: 4540-4546, 2018
APA
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H. ... Park, J. (2018). The roles of TRIO and F-actin-binding protein in glioblastoma cells. Molecular Medicine Reports, 17, 4540-4546. https://doi.org/10.3892/mmr.2018.8458
MLA
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S., Park, J."The roles of TRIO and F-actin-binding protein in glioblastoma cells". Molecular Medicine Reports 17.3 (2018): 4540-4546.
Chicago
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S., Park, J."The roles of TRIO and F-actin-binding protein in glioblastoma cells". Molecular Medicine Reports 17, no. 3 (2018): 4540-4546. https://doi.org/10.3892/mmr.2018.8458