Indoleamine 2, 3-dioxygenase regulation of immune response (Review)

  • Authors:
    • Hao Wu
    • Jianping Gong
    • Yong Liu
  • View Affiliations

  • Published online on: February 1, 2018     https://doi.org/10.3892/mmr.2018.8537
  • Pages: 4867-4873
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Abstract

Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed by professional antigen presenting cells (APCs), epithelial cells, vascular endothelium and tumor cells. IDO‑mediated catabolic products, which are additionally termed ʻkynureninesʼ, exerts important immunosuppressive functions primarily via regulating T effector cell anergy and inducing the proliferation of T regulatory cells. This endogenous tolerogenic pathway has a critical effect on mediating the magnitude of immune responses under various stress conditions, including tumor, infection and transplantation. The present review evaluates the recent progress in elucidating how catabolism of tryptophan regulated by IDO modulates the immune response to inflammatory and immunological signals. Blocking this pathway may be a novel adjuvant therapeutic strategy for clinical application in immunotherapy.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wu H, Gong J and Liu Y: Indoleamine 2, 3-dioxygenase regulation of immune response (Review). Mol Med Rep 17: 4867-4873, 2018
APA
Wu, H., Gong, J., & Liu, Y. (2018). Indoleamine 2, 3-dioxygenase regulation of immune response (Review). Molecular Medicine Reports, 17, 4867-4873. https://doi.org/10.3892/mmr.2018.8537
MLA
Wu, H., Gong, J., Liu, Y."Indoleamine 2, 3-dioxygenase regulation of immune response (Review)". Molecular Medicine Reports 17.4 (2018): 4867-4873.
Chicago
Wu, H., Gong, J., Liu, Y."Indoleamine 2, 3-dioxygenase regulation of immune response (Review)". Molecular Medicine Reports 17, no. 4 (2018): 4867-4873. https://doi.org/10.3892/mmr.2018.8537