Open Access

Expression profiles of long noncoding RNAs and mRNAs in post-cardiac arrest rat brains

  • Authors:
    • Rong Liu
    • Xiaoxing Liao
    • Xin Li
    • Hongyan Wei
    • Qing Liang
    • Zuopeng Zhang
    • Meixian Yin
    • Xiaoyun Zeng
    • Zijing Liang
    • Chunlin Hu
  • View Affiliations

  • Published online on: March 7, 2018     https://doi.org/10.3892/mmr.2018.8703
  • Pages: 6413-6424
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To investigate long noncoding (lnc)-RNA and mRNA expression profiles in post‑cardiac arrest (CA) brains, an external transthoracic electrical current was applied for 8 min to induce CA (the CA group). A total of 4 rats received sham-operations and served as the blank control (BC) group. Upon return of spontaneous circulation (ROSC), lncRNA and mRNA expression in the rat cerebral cortex was assayed with high‑throughput Agilent lncRNA and mRNA microarrays. In total, 37 lncRNAs were upregulated and 21 lncRNAs were downregulated in the CA group, and 258 mRNA transcripts were differentially expressed with 177 mRNAs upregulated and 81 mRNAs downregulated in the CA group. The differentially expressed lncRNAs in the CA group were co‑expressed with thousands of mRNAs. The differentially expressed lncRNAs could be clustered into >100 signaling pathways and processes according to Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses. The most common predicted functions involved metabolic pathways, protein synthesis, transport and degradation during CA‑ROSC. CA‑ROSC led to significant alterations in cerebral lncRNA and mRNA expression profiles. Thus, lncRNA‑mRNA network interactions have the potential to regulate vital metabolic pathways and processes involved in CA-ROSC.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Liu R, Liao X, Li X, Wei H, Liang Q, Zhang Z, Yin M, Zeng X, Liang Z, Hu C, Hu C, et al: Expression profiles of long noncoding RNAs and mRNAs in post-cardiac arrest rat brains. Mol Med Rep 17: 6413-6424, 2018
APA
Liu, R., Liao, X., Li, X., Wei, H., Liang, Q., Zhang, Z. ... Hu, C. (2018). Expression profiles of long noncoding RNAs and mRNAs in post-cardiac arrest rat brains. Molecular Medicine Reports, 17, 6413-6424. https://doi.org/10.3892/mmr.2018.8703
MLA
Liu, R., Liao, X., Li, X., Wei, H., Liang, Q., Zhang, Z., Yin, M., Zeng, X., Liang, Z., Hu, C."Expression profiles of long noncoding RNAs and mRNAs in post-cardiac arrest rat brains". Molecular Medicine Reports 17.5 (2018): 6413-6424.
Chicago
Liu, R., Liao, X., Li, X., Wei, H., Liang, Q., Zhang, Z., Yin, M., Zeng, X., Liang, Z., Hu, C."Expression profiles of long noncoding RNAs and mRNAs in post-cardiac arrest rat brains". Molecular Medicine Reports 17, no. 5 (2018): 6413-6424. https://doi.org/10.3892/mmr.2018.8703